Výsledky vyhledávání - "Jill A. Dalton"

De-risking in Tier I CNS safety assessments is the primary function of study design and technical training of laboratory staff observers

Autor: David V. Gauvin, Zachary J. Zimmermann, Jill A. Dalton

Publikováno v: Regulatory toxicology and pharmacology : RTP. 129

Derisking is not a pharmaceutical industry strategy to reduce time, effort, or costs in drug development. Derisking strategies originated within the National Institutes of Health as a predicate to good science. There is a growing sentiment within dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f27b301d43eedda3cde3a6abefcc5f
https://pubmed.ncbi.nlm.nih.gov/35017023

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An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation

Autor: John Koerner, Michael K. Pugsley, William S. Redfern, Ray W. Chui, Jill A. Dalton, Malar Pannirselvam, Matthew M. Abernathy, C Michael Foley, Simon Authier, Gregory S. Friedrichs, Jean-Pierre Valentin, Vijay Urmaliya, Mary Jeanne Kallman, Todd Wisialowski, Tanja S. Zabka, Krystle Correll

Publikováno v: International journal of toxicology. 39(4)

Introduction: The Safety Pharmacology Society (SPS) conducted a membership survey to examine industry practices related mainly to cardiovascular (CV) safety pharmacology (SP). Methods: Questions addressed nonclinical study design, data analysis metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9bce007c2cc19a86f289347ce79b5e
https://pubmed.ncbi.nlm.nih.gov/32406289

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Metabolic cost of resistance in clubroot-resistant canola and napa cabbage

Autor: Mary Ruth McDonald, Jill A. Dalton, Bruce D. Gossen, Fadi Al-Daoud

Publikováno v: Canadian Journal of Plant Pathology. 39:25-36

Genetic resistance is widely used to manage clubroot (Plasmodiophora brassicae) in canola (Brassica napus) and other brassica crops. Replicated field trials were conducted with three clubroot-resistant cultivars and one susceptible cultivar of either

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c523d214ef600493a76de54e4bb9dd4
https://doi.org/10.1080/07060661.2017.1292550

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CNS Safety Screening Under ICH S7A Guidelines Requires Observations of Multiple Behavioral Units to Assess Motor Function

Autor: Mary-Jeanne Kallman, Jill A. Dalton, Theodore J. Baird, Zachary J. Zimmermann, David V. Gauvin

Publikováno v: International journal of toxicology. 38(5)

In the adoption of behavior as a critical end point in safety pharmacology and neurotoxicity screening, federal regulatory agencies have shifted the predominating scientific perspective from pharmacology back to the experimental analysis of behavior

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2dc75aa79f34f25edff970cd887ae6
https://pubmed.ncbi.nlm.nih.gov/31470748

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Extended recording of LMA in rats: Effects of IV catheters, 'comfort jackets' and chamber lids on arterial blood gas parameters

Autor: Theodore J. Baird, Zachary J. Zimmermann, David V. Gauvin, Jill A. Dalton

Publikováno v: Journal of pharmacological and toxicological methods. 99

The standard infrared photobeam locomotor activity system has been used extensively in neurobiology and neuropharmacology to study the functional impact of direct manipulations of the nervous system. There is interest in using the activity monitors t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c821c8571faae5c36489ef7b24eb0b
https://pubmed.ncbi.nlm.nih.gov/31158458

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