Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Jill A Hollenbach"'
Autor:
Wesley M Marin, Ravi Dandekar, Danillo G Augusto, Tasneem Yusufali, Bianca Heyn, Jan Hofmann, Vinzenz Lange, Jürgen Sauter, Paul J Norman, Jill A Hollenbach
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1008904 (2021)
The killer-cell immunoglobulin-like receptor (KIR) complex on chromosome 19 encodes receptors that modulate the activity of natural killer cells, and variation in these genes has been linked to infectious and autoimmune disease, as well as having bea
Externí odkaz:
https://doaj.org/article/4880db1e9f7e492dafc5a56310cfa057
Autor:
Kristen J. Wade, Rayo Suseno, Kerry Kizer, Jacqueline Williams, Juliano Boquett, Stacy Caillier, Nicholas R. Pollock, Adam Renschen, Adam Santaniello, Jorge R. Oksenberg, Paul J. Norman, Danillo G. Augusto, Jill A. Hollenbach
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract The extremely high levels of genetic polymorphism within the human major histocompatibility complex (MHC) limit the usefulness of reference-based alignment methods for sequence assembly. We incorporate a short-read, de novo assembly algorith
Externí odkaz:
https://doaj.org/article/da420c82ac434ddc86e06bc9431d32c9
Autor:
Vincent Damotte, Chao Zhao, Chris Lin, Eric Williams, Yoram Louzoun, Abeer Madbouly, Rochelle Kotlarz, Marissa McDaniel, Paul J. Norman, Yong Wang, Martin Maiers, Jill A. Hollenbach
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-8 (2024)
Abstract Background Questions persist around whether and how to use race or geographic ancestry in biomedical research and medicine, but these forms of self-identification serve as a critical tool to inform matching algorithms for human leukocyte ant
Externí odkaz:
https://doaj.org/article/cc593cf5f8c24223aa1e90a0d2c86c20
Autor:
Natasha Z R Steele, Jessie S Carr, Luke W Bonham, Ethan G Geier, Vincent Damotte, Zachary A Miller, Rahul S Desikan, Kevin L Boehme, Shubhabrata Mukherjee, Paul K Crane, John S K Kauwe, Joel H Kramer, Bruce L Miller, Giovanni Coppola, Jill A Hollenbach, Yadong Huang, Jennifer S Yokoyama
Publikováno v:
PLoS Medicine, Vol 14, Iss 3, p e1002272 (2017)
BackgroundAlzheimer disease (AD) is a progressive disorder that affects cognitive function. There is increasing support for the role of neuroinflammation and aberrant immune regulation in the pathophysiology of AD. The immunoregulatory human leukocyt
Externí odkaz:
https://doaj.org/article/f71e760be1ec49f9bf26347ba7290f7c
Autor:
Hugo G Hilton, Paul J Norman, Neda Nemat-Gorgani, Ana Goyos, Jill A Hollenbach, Brenna M Henn, Christopher R Gignoux, Lisbeth A Guethlein, Peter Parham
Publikováno v:
PLoS Genetics, Vol 11, Iss 8, p e1005439 (2015)
Modulating natural killer cell functions in human immunity and reproduction are diverse interactions between the killer cell immunoglobulin-like receptors (KIR) of Natural Killer (NK) cells and HLA class I ligands on the surface of tissue cells. Domi
Externí odkaz:
https://doaj.org/article/48d329440aa04ca99896e97fb5f0f631
Autor:
Jill A Hollenbach, Aliya Saperstein, Mark Albrecht, Cynthia Vierra-Green, Peter Parham, Paul J Norman, Martin Maiers
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135960 (2015)
We conducted a nationwide study comparing self-identification to genetic ancestry classifications in a large cohort (n = 1752) from the National Marrow Donor Program. We sought to determine how various measures of self-identification intersect with g
Externí odkaz:
https://doaj.org/article/fa55703ef080463e84006fd128c72b09
Autor:
Paul J Norman, Jill A Hollenbach, Neda Nemat-Gorgani, Lisbeth A Guethlein, Hugo G Hilton, Marcelo J Pando, Kwadwo A Koram, Eleanor M Riley, Laurent Abi-Rached, Peter Parham
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003938 (2013)
Interactions between HLA class I molecules and killer-cell immunoglobulin-like receptors (KIR) control natural killer cell (NK) functions in immunity and reproduction. Encoded by genes on different chromosomes, these polymorphic ligands and receptors
Externí odkaz:
https://doaj.org/article/3503166ed6d044509432b12c89929605
Autor:
Cynthia Vierra-Green, David Roe, Lihua Hou, Carolyn Katovich Hurley, Raja Rajalingam, Elaine Reed, Tatiana Lebedeva, Neng Yu, Mary Stewart, Harriet Noreen, Jill A Hollenbach, Lisbeth A Guethlein, Tao Wang, Stephen Spellman, Martin Maiers
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e47491 (2012)
The immune responses of natural killer cells are regulated, in part, by killer cell immunoglobulin-like receptors (KIR). The 16 closely-related genes in the KIR gene system have been diversified by gene duplication and unequal crossing over, thereby
Externí odkaz:
https://doaj.org/article/b656a21890b04c008cd7ab1b7b6f6f68
Autor:
Qin Ma, Danillo G. Augusto, Gonzalo Montero-Martin, Stacy J. Caillier, Kazutoyo Osoegawa, Bruce A. C. Cree, Stephen L. Hauser, Alessandro Didonna, Jill A. Hollenbach, Paul J. Norman, Marcelo Fernandez-Vina, Jorge R. Oksenberg
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundThe HLA-DRB1 gene in the major histocompatibility complex (MHC) region in chromosome 6p21 is the strongest genetic factor identified as influencing multiple sclerosis (MS) susceptibility. DNA methylation changes associated with MS have been
Externí odkaz:
https://doaj.org/article/e17816670eb94ed78dd6ec595e2f543c
Autor:
Luciana de Brito Vargas, Renata M. Dourado, Leonardo M. Amorim, Brenda Ho, Verónica Calonga-Solís, Hellen C. Issler, Wesley M. Marin, Marcia H. Beltrame, Maria Luiza Petzl-Erler, Jill A. Hollenbach, Danillo G. Augusto
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Regulation of NK cell activity is mediated through killer-cell immunoglobulin-like receptors (KIR) ability to recognize human leukocyte antigen (HLA) class I molecules as ligands. Interaction of KIR and HLA is implicated in viral infections, autoimmu
Externí odkaz:
https://doaj.org/article/e0143388507f49c5be7cd3e13f54b222