A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

Autor: Paul M. O’Neill, Richard K. Amewu, Susan A. Charman, Sunil Sabbani, Nina F. Gnädig, Judith Straimer, David A. Fidock, Emma R. Shore, Natalie L. Roberts, Michael H.-L. Wong, W. David Hong, Chandrakala Pidathala, Chris Riley, Ben Murphy, Ghaith Aljayyoussi, Francisco Javier Gamo, Laura Sanz, Janneth Rodrigues, Carolina Gonzalez Cortes, Esperanza Herreros, Iñigo Angulo-Barturén, María Belén Jiménez-Díaz, Santiago Ferrer Bazaga, María Santos Martínez-Martínez, Brice Campo, Raman Sharma, Eileen Ryan, David M. Shackleford, Simon Campbell, Dennis A. Smith, Grennady Wirjanata, Rintis Noviyanti, Ric N. Price, Jutta Marfurt, Michael J. Palmer, Ian M. Copple, Amy E. Mercer, Andrea Ruecker, Michael J. Delves, Robert E. Sinden, Peter Siegl, Jill Davies, Rosemary Rochford, Clemens H. M. Kocken, Anne-Marie Zeeman, Gemma L. Nixon, Giancarlo A. Biagini, Stephen A. Ward

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

Artemisinin-resistantPlasmodium is an increasing problem. Here, using a medicinal chemistry programme, the authors identify a tetraoxane-based drug candidate that shows no cross-resistance with an artemisinin-resistant strain (PfK13-C580Y) and is eff

Externí odkaz: https://doaj.org/article/d0b09995908d4fd1a466aa398f702f2f

Domestic Violence Advocacy: Complex Lives/Difficult Choices

Autor: Jill Davies, Eleanor Lyon

Externí odkaz: http://sk.sagepub.com/Books/domestic-violence-advocacy-2e

Evaluating risk, safety and efficacy of novel reproductive techniques and therapies through the EuroGTP II risk assessment tool

Autor: Esteve Trias, 1, Martine Nijs, 2, 3 4, Ioana Adina Rugescu, Francesco Lombardo, 5, Gueorgui Nikolov, 5, Veerle Provoost, 6, Annelies Tolpe, 7, Nathalie Vermeulen, 8, Zdravka Veleva, 9, Rita Piteira 10, Ricardo Casaroli-Marano 10, Kelly Tilleman, 7, EuroGTP II Study Group:EuroGTP II Study Group: Anna Vilarrodona, A Rita Piteira, Elba, Agustí, Elisabet, Tahull, Esteve, Trias, Eva Maria Martinez, Ivan, Miranda, Jaime, Tabera, Maria Luisa Perez, Marta, Torrabadella, Nausica, Otero, Oscar, Fariñas, Patricia, López-Chicón, Sergi, Querol, Ricardo, Casaroli, Akila, Chandrasekar, Kyle, Bennett, Paul, Rooney, Richard, Lomas, Mar, Carmona, Esteban, Molano, Myriam, Ormeño, Branka Golubić Ćepulić, Ivan, Rozman, Marijana, Dragović, Cristina, Pintus, Eliana, Porta, Fiorenza, Bariani, Letizia, Lombardini, Liliam, Santilli, Mariapia, Mariani, Paola Di Ciaccio, Silvia, Pisanu, Artur, Kamiński, Izabela, Uhrynowska-Tyszkiewicz, Ewa, Olender, Anne Marie van Walraven, Arlinke, Bokhorst, Ingrid van Veen, Kelly, Tilleman, Tolpe, Annelies, Veerle, Provoost, Lieve, Nuytinck, Maryana, Simeonova, Daniela, Staneva-Petkova, Dessislava, Tzoneva, Tsvetelina, Kircheva-Nikolova, Violetta, Marinkova, Valery, Georgiev, Yoran, Peev, Elizabeth, Manova, Cecilia, Surján, Éva, Belicza, Gábor, Szarvas, Judit, Lám, László, Bencze, Martin, Börgel, Mareike, Derks, Sibylla, Schwarz, Ramadan, Jashari, Richard, N Noumanje, Rosario Daiz Rodriguez, Tiia, Tallinen, Hanna, Kankkonen, Toni-Karri, Pakarinen, Gilbert, Verbeken, Jean-Paul, Pirnay, Thomas, Rose, Jean-Pierre, Draye, Simone, Hennerbichler, Jill, Davies, Jacinto, Ibañez, Cristina, Magli, Nathalie, Vermeulen, Monserrat, Boada, Eoin, Mcgrath, John, Armitage, Gary, Jones, Marta, Fraga, Dulce, Roldao, Josefina, Oliveira, Adolfo, Paolin, Diletta, Trojan, Giulia, Montagner, Diego, Ponzin, Stefano, Ferrari, Lombardo, Francesco, Carlijn, Voermans, Nelleke, Richters, Ioana Adina Rugescu, Gianpaolo, Azzena, Fabozzo, Assunta, Helene, Schoenmans, Jose Luis Pomar, Pablo, Gelber, Katalin, Rajczy, Boris, Calmels, Stephan, Mielke, Tanja, Netelenbos, Mirko, Ragazzo, Gueorgui, Nikolov, Marton, Elisabetta, Martine, Nijs, Antonella, Franch, Gianluca, Piovan, Francesco, Dell'Antonia, Martyn, Snow, Ines, Bojanic, Zdravka, Veleva, Grezgorz, Basak, Margarida, Amil, Sandra, Shaw, Aurora, Navarro, Tim, Spalding, Peter, Verdonk

Publikováno v: HUMAN REPRODUCTION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

STUDY QUESTIONCan risks associated with novelties in assisted reproduction technologies (ARTs) be assessed in a systematic and structured way?SUMMARY ANSWERAn ART-specific risk assessment tool has been developed to assess the risks associated with th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea0401d1ea8c053a33c59df9c2b6561
https://doi.org/10.1093/humrep/deaa146

Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis

Autor: Ghaith Aljayyoussi, Hayley E. Tyrer, Louise Ford, Hanna Sjoberg, Nicolas Pionnier, David Waterhouse, Jill Davies, Joanne Gamble, Haelly Metuge, Darren A. N. Cook, Andrew Steven, Raman Sharma, Ana F. Guimaraes, Rachel H. Clare, Andrew Cassidy, Kelly L. Johnston, Laura Myhill, Laura Hayward, Samuel Wanji, Joseph D. Turner, Mark J. Taylor, Stephen A. Ward

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)

A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.

Externí odkaz: https://doaj.org/article/e385b0ad0b0a47df831e0a685925f5a2

Serious adverse events are uncommon with combination neonatal antiretroviral prophylaxis: a retrospective case review.

Autor: Christiana Smith, Jeri E Forster, Myron J Levin, Jill Davies, Jennifer Pappas, Kay Kinzie, Emily Barr, Suzanne Paul, Elizabeth J McFarland, Adriana Weinberg

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0127062 (2015)

Six weeks of zidovudine (ZDV) is recommended for postnatal prophylaxis of HIV-exposed infants, but combination antiretrovirals are indicated if HIV transmission risk is increased. We investigated the frequency and severity of adverse events (AE) in i

Externí odkaz: https://doaj.org/article/d55ed0b4b1034be2a568455fc44c98db