Zobrazeno 1 - 10 of 40 pro vyhledávání: '"Jill H. Fowler"'
1
Akademický článek
Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration
Autor: Irene Molina-Gonzalez, Rebecca K. Holloway, Zoeb Jiwaji, Owen Dando, Sarah A. Kent, Katie Emelianova, Amy F. Lloyd, Lindsey H. Forbes, Ayisha Mahmood, Thomas Skripuletz, Viktoria Gudi, James A. Febery, Jeffrey A. Johnson, Jill H. Fowler, Tanja Kuhlmann, Anna Williams, Siddharthan Chandran, Martin Stangel, Andrew J. M. Howden, Giles E. Hardingham, Veronique E. Miron
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Failed regeneration of myelin around neuronal axons following central nervous system damage contributes to nerve dysfunction and clinical decline in various neurological conditions, for which there is an unmet therapeutic demand. Here, we sh
Externí odkaz: https://doaj.org/article/c24c9e61819a48939d2ddccda235b862
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2
Akademický článek
Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment
Autor: Emma Sigfridsson, Martina Marangoni, Giles E. Hardingham, Karen Horsburgh, Jill H. Fowler
Publikováno v: Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Background Chronic cerebral hypoperfusion causes damage to the brain’s white matter underpinning vascular cognitive impairment. Inflammation and oxidative stress have been proposed as key pathophysiological mechanisms of which the transcri
Externí odkaz: https://doaj.org/article/7e3e2881787e4c44b3dfb9692b7f07a6
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3
Akademický článek
Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusion
Autor: Emma Sigfridsson, Martina Marangoni, Jeffrey A. Johnson, Giles E. Hardingham, Jill H. Fowler, Karen Horsburgh
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Mouse models have shown that cerebral hypoperfusion causes white matter disruption and memory impairment relevant to the study of vascular cognitive impairment and dementia. The associated mechanisms include inflammation and oxidative stress
Externí odkaz: https://doaj.org/article/d600fb320b054084b56284ae738c586b
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5
Akademický článek
Restoration of oligodendrocyte pools in a mouse model of chronic cerebral hypoperfusion.
Autor: Jamie McQueen, Michell M Reimer, Philip R Holland, Yasmina Manso, Mark McLaughlin, Jill H Fowler, Karen Horsburgh
Publikováno v: PLoS ONE, Vol 9, Iss 2, p e87227 (2014)
Chronic cerebral hypoperfusion, a sustained modest reduction in cerebral blood flow, is associated with damage to myelinated axons and cognitive decline with ageing. Oligodendrocytes (the myelin producing cells) and their precursor cells (OPCs) may b
Externí odkaz: https://doaj.org/article/2cb44815c5c14670820d6e19fbe5aa82
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6
Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment
Autor: Karen Horsburgh, Emma Sigfridsson, Giles E. Hardingham, Martina Marangoni, Jill H. Fowler
Publikováno v: Journal of Neuroinflammation
Sigfridsson, E, Marangoni, M, Hardingham, G, Horsburgh, K & Fowler, J 2020, ' Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment ', Journal of Neuroinflammation . https://doi.org/10.1186/s12974-020-02038-2
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Background Chronic cerebral hypoperfusion causes damage to the brain’s white matter underpinning vascular cognitive impairment. Inflammation and oxidative stress have been proposed as key pathophysiological mechanisms of which the transcription fac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86c31f5384f7f4a08b2051f00561585
http://europepmc.org/articles/PMC7709339
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7
UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment : questionnaire and workshop proceedings
Autor: Malcolm R. Macleod, Margaux Aimable, Scott Miners, Matthew MacGregor Sharp, Hilary V O Carswell, Philip M.W. Bath, Ashton Bernard, Emily S. Sena, Claire S. White, Rhian M. Touyz, Patrick G. Kehoe, Tracy D. Farr, Lorraine M. Work, Stefan Szymkowiak, Gillian L. Currie, Catherine N. Hall, Bettina Platt, Andrew N. Clarkson, Gaia Brezzo, Stuart M. Allan, Mark Andrew Good, Roxana O. Carare, Alison D. McNeilly, Alyson A. Miller, Jill H. Fowler, Barry W. McColl, Tuuli M Hietamies, Christopher McCabe, Rebecca C. Trueman, Vincent Mok, Rajesh N. Kalaria, Michael O'Sullivan, Terence J. Quinn, Karen Horsburgh, Atticus H. Hainsworth, Patrick Strangeward, Catherine E. Lawrence, Aisling McFall
Publikováno v: McFall, A, Hietamies, T M, Bernard, A, Aimable, M, Allan, S M, Bath, P M, Brezzo, G, Carare, R O, Carswell, H V, Clarkson, A N, Currie, G, Farr, T D, Fowler, J, Good, M, Hainsworth, A H, Hall, C, Horsburgh, K, Kalaria, R, Kehoe, P, Lawrence, C, MacLeod, M, McNeilly, A, Miller, A A, Miners, S, Mok, V, O'Sullivan, M, Platt, B, Sena, E, Sharp, M, Strangeward, P, Szymkowiak, S, Touyz, R M, Trueman, R C, White, C, McCabe, C, Work, L M & Quinn, T J 2020, ' UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings ', Journal of Cerebral Blood Flow and Metabolism . https://doi.org/10.1177/0271678X20910552
Journal of Cerebral Blood Flow & Metabolism
McFall, A, Hietamies, T M, Bernard, A, Aimable, M, Allan, S M, Bath, P M, Brezzo, G, Carare, R O, Carswell, H V, Clarkson, A N, Currie, G, Farr, T D, Fowler, J H, Good, M, Hainsworth, A H, Hall, C, Horsburgh, K, Kalaria, R, Kehoe, P, Lawrence, C, Macleod, M, McColl, B W, McNeilly, A, Miller, A A, Miners, S, Mok, V, O'Sullivan, M, Platt, B, Sena, E S, Sharp, M, Strangeward, P, Szymkowiak, S, Touyz, R M, Trueman, R C, White, C, McCabe, C, Work, L M & Quinn, T J 2020, ' UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment : questionnaire and workshop proceedings ', Journal of Cerebral Blood Flow and Metabolism . https://doi.org/10.1177/0271678X20910552
Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine underlying variability and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eef0fbd3bfb3e2bea0c06634a444e02
https://strathprints.strath.ac.uk/71920/7/McFall_etal_JCBFM_2020_UK_consensus_on_pre_clinical_vascular_cognitive.pdf
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8
Neuronal Activity and Its Role in Controlling Antioxidant Genes
Autor: Siddharthan Chandran, Owen Dando, James A. Febery, Giles E. Hardingham, Jill H. Fowler, Jing Qiu
Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 6, p 1933 (2020)
International Journal of Molecular Sciences
Qiu, J, Dando, O, Febery, J A, Fowler, J H, Chandran, S & Hardingham, G E 2020, ' Neuronal Activity and Its Role in Controlling Antioxidant Genes ', International Journal of Molecular Sciences, vol. 21, no. 6, pp. 1933 . https://doi.org/10.3390/ijms21061933
Forebrain neurons have relatively weak intrinsic antioxidant defenses compared to astrocytes, in part due to hypo-expression of Nrf2, an oxidative stress-induced master regulator of antioxidant and detoxification genes. Nevertheless, neurons do posse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34580091fecc717c2c7422ad9c845a03
https://www.mdpi.com/1422-0067/21/6/1933
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9
Connecting to motor recovery after stroke
Autor: Raj N. Kalaria, Jill H. Fowler
Publikováno v: Brain Communications. 2
This scientific commentary refers to ‘Structural brain networks and functional motor outcome after stroke –a prospective cohort study’, by Schlemm et al. (https://doi.org/10.1093/braincomms/fcaa001) in Brain Communications and ‘Brain responsi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02b6b5230f971a916c3c136f14b5fbd1
https://doi.org/10.1093/braincomms/fcaa067
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10
Workshop proceedings, Jan 25-26th 2017
Autor: Karen Horsburgh, Joanna M. Wardlaw, Tom van Agtmael, Stuart M. Allan, Mike L.J. Ashford, Philip M. Bath, Rosalind Brown, Jason Berwick, M. Zameel Cader, Roxana O. Carare, John B. Davis, Jessica Duncombe, Tracy D. Farr, Jill H. Fowler, Jozien Goense, Alessandra Granata, Catherine N. Hall, Atticus H. Hainsworth, Adam Harvey, Cheryl A. Hawkes, Anne Joutel, Rajesh N. Kalaria, Patrick G. Kehoe, Catherine B. Lawrence, Andy Lockhart, Seth Love, Malcolm R. Macleod, I. Mhairi Macrae, Hugh S. Markus, Chris McCabe, Barry W. McColl, Paul J. Meakin, Alyson Miller, Maiken Nedergaard, Michael O'Sullivan, Terry J. Quinn, Rikesh Rajani, Lisa M. Saksida, Colin Smith, Kenneth J. Smith, Rhian M. Touyz, Rebecca C. Trueman, Tao Wang, Anna Williams, Steven C.R. Williams, Lorraine M. Work
Publikováno v: Brain and Mind Institute Researchers' Publications
Horsburgh, K, Wardlaw, J M, van Agtmael, T, Allan, S M, Ashford, M L J, Bath, P M, Brown, R, Berwick, J, Cader, M Z, Carare, R O, Davis, J B, Duncombe, J, Farr, T D, Fowler, J H, Goense, J, Granata, A, Hall, C N, Hainsworth, A H, Harvey, A, Hawkes, C A, Joutel, A, Kalaria, R N, Kehoe, P G, Lawrence, C B, Lockhart, A, Love, S, Macleod, M R, Macrae, I M, Markus, H S, McCabe, C, McColl, B W, Meakin, P J, Miller, A, Nedergaard, M, O'Sullivan, M, Quinn, T J, Rajani, R, Saksida, L M, Smith, C, Smith, K J, Touyz, R M, Trueman, R C, Wang, T, Williams, A, Williams, S C R & Work, L M 2018, ' Small vessels, dementia and chronic diseases-molecular mechanisms and pathophysiology ', Clinical Science, vol. 132, no. 8, pp. 851-868 . https://doi.org/10.1042/CS20171620
Horsburgh, K, Wardlaw, J M, van Agtmael, T, Allan, S M, Ashford, M L J, Bath, P M, Brown, R, Berwick, J, Cader, M Z, Carare, R O, Davis, J B, Duncombe, J, Farr, T D, Fowler, J H, Goense, J, Granata, A, Hall, C N, Hainsworth, A H, Harvey, A, Hawkes, C A, Joutel, A, Kalaria, R N, Kehoe, P G, Lawrence, C B, Lockhart, A, Love, S, Macleod, M R, Macrae, I M, Markus, H S, McCabe, C, McColl, B W, Meakin, P J, Miller, A, Nedergaard, M, O'Sullivan, M, Quinn, T J, Rajani, R, Saksida, L M, Smith, C, Smith, K J, Touyz, R M, Trueman, R C, Wang, T, Williams, A, Williams, S C R & Work, L M 2018, ' Small vessels, dementia and chronic diseases-molecular mechanisms and pathophysiology ', Clinical science (London, England : 1979), vol. 132, no. 8, pp. 851-868 . https://doi.org/10.1042/CS20171620
Horsburgh, K, Wardlaw, J M, van Agtmael, T, Allan, S M, Ashford, M L J, Bath, P M, Brown, R, Berwick, J, Cader, M Z, Carare, R O, Duncombe, J, Farr, T D, Fowler, J H, Goense, J, Granata, A, Hall, C N, Hainsworth, A H, Harvey, A, Hawkes, C A, Joutel, A, Kalaria, R N, Kehoe, P G, Lawrence, C B, Lockhart, A, Love, S, Macleod, M R, Macrae, I M, Markus, H S, McCabe, C, McColl, B W, Meakin, P J, Miller, A, Nedergaard, M, Quinn, T J, Rajani, R, Saksida, L M, Touyz, R M, Trueman, R C, Wang, T & Work, L M 2018, ' Small vessels, dementia and chronic diseases-molecular mechanisms and pathophysiology ', Clinical Science, vol. 132, no. 8, pp. 851-868 . https://doi.org/10.1042/CS20171620
Cerebral small vessel disease (SVD) is a major health challenge. Therapeutic approaches remain limited, hampered by the lack of mechanistic understanding and identification of therapeutic targets. Relevant animal models could provide a cornerstone to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c214bd16b0e0beaca6e1da1d0a12c9
https://ir.lib.uwo.ca/brainpub/787
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