Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene

Autor: Hoeffken Gerd, Haeußinger Karl, Kreymborg Karsten, Groeschel Andreas, Drings Peter, Morr Harald, Degen Maria, Cebulla Mathias, Woelke Gabi, Sybrecht Gerhard, Meese Eckart, Dienemann Hendrik, Klopp Norman, Timofeeva Maria, Illig Thomas, Rosenberger Albert, Sauter Wiebke, Mittelstrass Kirstin, Schmidt Christine, Jilge Bettina, Schmidt Wilhelm, Ko You-Dschun, Taeuscher Dagmar, Chang-Claude Jenny, Wichmann Heinz-Erich, Bickeboeller Heike, Risch Angela

Publikováno v: BMC Cancer, Vol 8, Iss 1, p 113 (2008)

Abstract The polymorphism SNP309 (rs2279744) in the promoter region of the MDM2 gene has been shown to alter protein expression and may play a role in the susceptibility to lung cancer. The MDM2 protein is a key inhibitor of p53 and several mechanism

Externí odkaz: https://doaj.org/article/e0c06ca54e3046ec8104ada66d77bb4b

Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years

Autor: Rosenberger, Albert, Illig, Thomas, Korb, Katrin, Klopp, Norman, Zietemann, Vera, Wölke, Gabi, Meese, Eckart, Sybrecht, Gerhard, Kronenberg, Florian, Cebulla, Matthias, Degen, Maria, Drings, Peter, Gröschel, Andreas, Konietzko, Nikolaus, Grosse Kreymborg, Karsten, Häußinger, Karl, Höffken, Gerd, Jilge, Bettina, Ko, You-Dschun, Morr, Harald

Background: Early onset lung cancer shows some familial aggregation, pointing to a genetic predisposition. This study was set up to investigate the role of candidate genes in the susceptibility to lung cancer patients younger than 51 years at diagnos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1688::44e4d1c8d241cf3b88a5e25e86f31f15
http://resolver.sub.uni-goettingen.de/purl?gs-1/4326

Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years.

Autor: Rosenberger A; Department of Genetic Epidemiology, Georg-August University of Göttingen, Medical School, Germany. arosenb@gwdg.de, Illig T, Korb K, Klopp N, Zietemann V, Wölke G, Meese E, Sybrecht G, Kronenberg F, Cebulla M, Degen M, Drings P, Gröschel A, Konietzko N, Kreymborg KG, Häussinger K, Höffken G, Jilge B, Ko YD, Morr H, Schmidt C, Schmidt EW, Täuscher D, Bickeböller H, Wichmann HE

Publikováno v: BMC cancer [BMC Cancer] 2008 Feb 25; Vol. 8, pp. 60. Date of Electronic Publication: 2008 Feb 25.