Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Jijun Hao"'
Autor:
Bowen Gao, Jiongyu Chen, Bingchen Han, Xinfeng Zhang, Jijun Hao, Armando E. Giuliano, Yukun Cui, Xiaojiang Cui
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Triple-negative breast cancer (TNBC) is associated with a high rate of early recurrence and distant metastasis, frequent development of therapeutic resistance, and a poor prognosis. There is a lack of targeted therapies for this aggressive s
Externí odkaz:
https://doaj.org/article/0c576c9d1a8f4aa88792c764c17985e6
Autor:
Jeffrey Koury, Ana Ramirez, Chen Xie, Jerry Harb, Charli Dong, Chad Maki, Tom Ramos, Fari Izadyar, David Clark, Yvonne Drechsler, Gagandeep Kaur, Jijun Hao
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218670 (2019)
Canine Atopic Dermatitis (AD) is a common complex and multifactorial disease involving immune dysregulation, genetic predisposition, skin barrier defects, environmental factors and allergic sensitization. To date, diagnosis of canine AD relies on a c
Externí odkaz:
https://doaj.org/article/da98824e7a1a463887dcc9724af81406
Publikováno v:
Biomedicines, Vol 9, Iss 5, p 538 (2021)
Prostate cancer chemoresistance is a major therapeutic problem, and the underlying mechanism is not well understood and effective therapies to overcome this problem are not available. Phosphodiesterase-4 (PDE4), a main intracellular enzyme for cAMP h
Externí odkaz:
https://doaj.org/article/35d048bad67e4b8bb0199fdef952db27
Publikováno v:
Stem Cell Research, Vol 15, Iss 3, Pp 731-741 (2015)
Stem cell-based neuronal differentiation has provided a unique opportunity for disease modeling and regenerative medicine. Neurospheres are the most commonly used neuroprogenitors for neuronal differentiation, but they often clump in culture, which h
Externí odkaz:
https://doaj.org/article/039918de8d1d4af69ce9beb037445ca1
Autor:
Bingchen Han, Ying Qu, Yanli Jin, Yi Yu, Nan Deng, Kolja Wawrowsky, Xiao Zhang, Na Li, Shikha Bose, Qiang Wang, Sugunadevi Sakkiah, Ravinder Abrol, Tor W. Jensen, Benjamin P. Berman, Hisashi Tanaka, Jeffrey Johnson, Bowen Gao, Jijun Hao, Zhenqiu Liu, Ralph Buttyan, Partha S. Ray, Mien-Chie Hung, Armando E. Giuliano, Xiaojiang Cui
Publikováno v:
Cell Reports, Vol 13, Iss 5, Pp 1046-1058 (2015)
The mesoderm- and epithelial-mesenchymal transition-associated transcription factor FOXC1 is specifically overexpressed in basal-like breast cancer (BLBC), but its biochemical function is not understood. Here, we demonstrate that FOXC1 controls cance
Externí odkaz:
https://doaj.org/article/2f476aea81b34e19b5381ab1d419696a
Autor:
Charles H. Williams, Jonathan E. Hempel, Jijun Hao, Audrey Y. Frist, Michelle M. Williams, Jonathan T. Fleming, Gary A. Sulikowski, Michael K. Cooper, Chin Chiang, Charles C. Hong
Publikováno v:
Cell Reports, Vol 11, Iss 1, Pp 43-50 (2015)
Hedgehog (Hh) signaling plays an integral role in vertebrate development, and its dysregulation has been accepted widely as a driver of numerous malignancies. While a variety of small molecules target Smoothened (Smo) as a strategy for Hh inhibition,
Externí odkaz:
https://doaj.org/article/47e8bc09c7cc428c932ffb7a41a5037b
Autor:
Wesley M Botello-Smith, Abdelaziz Alsamarah, Payal Chatterjee, Chen Xie, Jerome J Lacroix, Jijun Hao, Yun Luo
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 8, p e1005711 (2017)
Type 1 Serine/Threonine Kinase Receptors (STKR1) transduce a wide spectrum of biological signals mediated by TGF-β superfamily members. The STKR1 activity is tightly controlled by their regulatory glycine-serine rich (GS) domain adjacent to the kina
Externí odkaz:
https://doaj.org/article/7e75fa95b46d43c288fd9e4e90322b4d
Publikováno v:
Stem Cells International, Vol 2017 (2017)
The Wnt, Hedgehog, and Notch pathways are inherent signaling pathways in normal embryogenesis, development, and hemostasis. However, dysfunctions of these pathways are evident in multiple tumor types and malignancies. Specifically, aberrant activatio
Externí odkaz:
https://doaj.org/article/3ec2311db55a4fd2a5636998d37fb826
Publikováno v:
Stem Cells International, Vol 2017 (2017)
Externí odkaz:
https://doaj.org/article/8d8b19b19a384a6a9524fb45706d9c74
Autor:
Jijun Hao, Ada Ao, Li Zhou, Clare K. Murphy, Audrey Y. Frist, Jessica J. Keel, Curtis A. Thorne, Kwangho Kim, Ethan Lee, Charles C. Hong
Publikováno v:
Cell Reports, Vol 4, Iss 5, Pp 898-904 (2013)
The canonical Wnt signaling pathway, mediated by the transcription factor β-catenin, plays critical roles in embryonic development and represents an important therapeutic target. In a zebrafish-based in vivo screen for small molecules that specifica
Externí odkaz:
https://doaj.org/article/c65b8a96757843c4ba6156e64d153833