Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jiing Jyh Jan"'
Autor:
Kai-Chia Yeh, Chia-Jui Lee, Jen-Shin Song, Chien-Huang Wu, Teng-Kuang Yeh, Szu-Huei Wu, Tsung-Chin Hsieh, Yen-Ting Chen, Huan-Yi Tseng, Chen-Lung Huang, Chiung-Tong Chen, Jiing-Jyh Jan, Ming-Chen Chou, Kak-Shan Shia, Kuang-Hsing Chiang
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11730
CXCR4 antagonists have been claimed to reduce mortality after myocardial infarction in myocardial infarction (MI) animals, presumably due to suppressing inflammatory responses caused by myocardial ischemia-reperfusion injury, thus, subsequently facil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c4e017bb2221055542384ec9de728f
https://doi.org/10.3390/ijms231911730
https://doi.org/10.3390/ijms231911730
Autor:
Yi-Yu Ke, Ming-Chen Chou, Jiing-Jyh Jan, Trinh Kieu Dinh, Chien-Huang Wu, Chia-Jui Lee, Kai-Chia Yeh, Jing-Kai Huang, Yen-Nhi Ngoc Ta, Kuan-Wei Huang, Kak-Shan Shia, Jen-Shin Song, Yun-Chieh Sung, Chih-Chun Chang, Teng-Kuang Yeh, Ting-Yun Shiue, Yunching Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance A highly selective, safe, and potent CXCR4 antagonist, BPRCX807, has been designed and experimentally validated in various hepatocellular carcinoma models. Through combination therapy, it can synergize with either a kinase (e.g., sorafen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5b594bec713b18d964bcc9a233a691
https://pubmed.ncbi.nlm.nih.gov/33753481
https://pubmed.ncbi.nlm.nih.gov/33753481
Autor:
Yu-Syuan Wang, Chien-Huang Wu, Eunkyung Bae, Jiing-Jyh Jan, Seong-Jin Yu, Kak-Shan Shia, Kuo-Jen Wu, Jen-Shin Song, Hsi Chen, Yun Wang
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 7085, p 7085 (2020)
Volume 21
Issue 19
International Journal of Molecular Sciences, Vol 21, Iss 7085, p 7085 (2020)
Volume 21
Issue 19
Intracerebral hemorrhage (ICH) is a major cause of stroke, with high mortality and morbidity. There is no effective pharmacological therapy for ICH. Previous studies have indicated that CXCR4 antagonists reduced microglia activation, attenuated infil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fb12387637b0b3f2b571116c856406
https://doi.org/10.3390/ijms21197085
https://doi.org/10.3390/ijms21197085
Autor:
Yi-Yu Ke, Jiing-Jyh Jan, Chen-Tso Tseng, Chen-Lung Huang, Kai-Chia Yeh, Ming-Chen Chou, Chiung-Tong Chen, Szu-Huei Wu, Chia-Jui Lee, Sing-Yi Wang, Lun K. Tsou, Jen-Shin Song, Kak-Shan Shia, Chien-Huang Wu, Po-Chu Kuo, Teng-Kuang Yeh, Hsuan‐Hao Kuan, Mine-Hsine Wu
Publikováno v:
Journal of medicinal chemistry. 61(3)
The function of the CXCR4/CXCL12 axis accounts for many disease indications, including tissue/nerve regeneration, cancer metastasis, and inflammation. Blocking CXCR4 signaling with its antagonists may lead to moving out CXCR4+ cell types from bone ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673e4a8498bb2f6a8a1ac4e555d7c1e3
https://pubmed.ncbi.nlm.nih.gov/29314840
https://pubmed.ncbi.nlm.nih.gov/29314840
Autor:
Chuan Jen Wang, Amit A. Sadani, Hsin Pang Hsieh, Elizabeth A. Gullen, Yung-Chi Cheng, Chia-Yi Cheng, Yun Chen Tien, Jing Ma, Ming Chen Chou, Chun-Ping Chang, Yi Yu Ke, Chen Fu Lo, Lun K. Tsou, Tsung Chih Hsieh, Jiing Jyh Jan, Jen Shin Song, Yu Wei Liu, Ying Chieh Wong, Chia Hua Tsai, Chien Huang Wu, Kak Shan Shia
Publikováno v:
Journal of Medicinal Chemistry. 58:1452-1465
Motivated by the pivotal role of CXCR4 as an HIV entry co-receptor, we herein report a de novo hit-to-lead effort on the identification of subnanomolar purine-based CXCR4 antagonists against HIV-1 infection. Compound 24, with an EC50 of 0.5 nM agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa19206a3e5b5af84e76abcf8c074d1b
https://doi.org/10.1021/jm501772w
https://doi.org/10.1021/jm501772w
Autor:
Jen-Shin Song, Chih-Chun Chang, Chien-Huang Wu, Trinh Kieu Dinh, Jiing-Jyh Jan, Kuan-Wei Huang, Ming-Chen Chou, Ting-Yun Shiue, Kai-Chia Yeh, Yi-Yu Ke, Teng-Kuang Yeh, Yen-Nhi Ngoc Ta, Chia-Jui Lee, Jing-Kai Huang, Yun-Chieh Sung, Kak-Shan Shia, Yunching Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 3/30/2021, Vol. 118 Issue 13, p1-11, 11p
Autor:
Kak-Shan Shia, Wei-Han Chen, Jiing-Jyh Jan, Chien-Huang Wu, Lun K. Tsou, Teng-Kuang Yeh, Yu-Wei Liu, Chen-Fu Lo, Kuan-Liang Liu, Koon Y. Pak, Chen-Lung Huang, Ming-Yu Fang, Tsu-An Hsu, Yu-Chen Huang, Yun-Yu Chen, Chiung-Tong Chen, Yu‐Cheng Yeh, Kuan-Hsun Huang, Brian D. Gray
Publikováno v:
Bioconjugate chemistry. 28(7)
A series of zinc(II) dipicolylamine (ZnDPA)-based drug conjugates have been synthesized to probe the potential of phosphatidylserine (PS) as a new antigen for small molecule drug conjugate (SMDC) development. Using in vitro cytotoxicity and plasma st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2f7d9d7a6d3c9504420311bec993b3
https://pubmed.ncbi.nlm.nih.gov/28581724
https://pubmed.ncbi.nlm.nih.gov/28581724
Autor:
Chien-Huang Wu, Ming-Shiu Hung, Chin-Yu Lin, Min-Tsang Hsieh, Jiing-Jyh Jan, Cheng-Ming Chu, Kak-Shan Shia, Ming-Chen Chou, Teng-Kuang Yeh, Horng-Shing Shy, Jen-Shin Song, Yu-Sheng Chao, Shi-Liang Tseng, Yen-Nan Yeh, Wan-Ping Hsieh, Yinchiu Lin, Chun-Wei Kuo, Wan-Ling Chung, Chun-Ping Chang
Publikováno v:
Journal of Medicinal Chemistry. 52:4496-4510
By using the active metabolite 5 as an initial template, further structural modifications led to the identification of the titled compound 24 (BPR-890) as a highly potent CB1 inverse agonist possessing an excellent CB2/1 selectivity and remarkable in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac6e20afdcf3fb9a8eaeaa8d2478da8
https://doi.org/10.1021/jm900471u
https://doi.org/10.1021/jm900471u
Autor:
Chung-Yu Huang, Jiing-Jyh Jan, Min-Hsien Wang, Szu-Huei Wu, Ming-Chen Chou, Kak-Shan Shia, Amit A. Sadani, Chen-Tso Tseng, Ying-Chieh Wong, Ching-Fang Yeh, Lun K. Tsou, Jen-Shin Song, Kai-Chia Yeh, Chia-Yi Cheng, Chien-Huang Wu, Chun-Ping Chang, Kuei-Hua Chang, Chiung-Tong Chen
Publikováno v:
Journal of medicinal chemistry. 58(5)
We have discovered a novel series of quinazoline-based CXCR4 antagonists. Of these, compound 19 mobilized CXCR4(+) cell types, including hematopoietic stem cells and endothelial progenitor cells, more efficiently than the marketed 1 (AMD3100) with su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c6a798c0b467d7f5daa9da53bc6718
https://pubmed.ncbi.nlm.nih.gov/25686267
https://pubmed.ncbi.nlm.nih.gov/25686267
Publikováno v:
The Journal of Organic Chemistry. 63:9131-9134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::645e8bd615e89f33e48e240a9fd65c41
https://doi.org/10.1021/jo981566x
https://doi.org/10.1021/jo981566x