Výsledky vyhledávání - "Jih-Pyang Wang"

Triterpenoids and an alkamide from Ganoderma tsugae

Autor: Jih-Pyang Wang, Dravidum Maitraie, Chun-Nan Lin, Kai-Wei Lin, A-Mei Huang

Publikováno v: Fitoterapia. 108:73-80

Ganoderma tsugae is a medicinal mushroom. In a continual study on the bioactive constituents of this fungus, a new lanostanoid, 3β-acetoxy-16α-hydroxy-24ξ-methyl-5α-lanosta-8,25-dien-21-oic acid, named tsugaric acid F (1) and a novel palmitamide,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe3d2592ce39c95be83f7693d1e64a8
https://doi.org/10.1016/j.fitote.2015.11.003

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Inhibition of formyl peptide-stimulated phospholipase D activation by Fal-002-2 via blockade of the Arf6, RhoA and protein kinase C signaling pathways in rat neutrophils

Autor: Yun-Jie Hung, Miau-Rong Lee, Jih-Pyang Wang, Li-Jiau Huang, Sheng-Chu Kuo, Hui-Yi Lin, Ya-Ru Tsai, Mei-Feng Hsu

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology. 386:507-519

Three recently developed selective phospholipase D (PLD) inhibitors N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-2-naphthamide (VU0155056), (S)-N-(1-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98a3c47d8f921d19d39b48fd1882003
https://doi.org/10.1007/s00210-013-0851-6

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p38 Mitogen-activated protein kinase and extracellular signal-regulated kinase signaling pathways are not essential regulators of formyl peptide-stimulated p47phox activation in neutrophils

Autor: Mei-Feng Hsu, Jih-Pyang Wang, Ya-Ru Tsai, Miau-Rong Lee, Yi-Jen Wang

Publikováno v: European Journal of Pharmacology. 701:96-105

Three structurally unrelated p38 mitogen-activated protein kinase (MAPK) inhibitors, (4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)imidazole (SB203580), 1-5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a765dfb246d872348752d6c92d57186e
https://doi.org/10.1016/j.ejphar.2013.01.003

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The signaling mechanisms mediating the inhibitory effect of TCH-1116 on formyl peptide-stimulated superoxide anion generation in neutrophils

Autor: Mei-Feng Hsu, Sheng-Chu Kuo, Jih-Pyang Wang, Li-Jiau Huang, Cherng-Chyi Tzeng, Miau-Rong Lee, Ya-Ru Tsai, Yeh-Long Chen

Publikováno v: European Journal of Pharmacology. 682:171-180

In fMLP (formyl-Met-Leu-Phe)-stimulated rat neutrophils, a mixture of regioisomers benzo[a]furo[2,3-c]phenazine-10-carboxylic acid and benzo[a]furo[2,3-c]phenazine-11-carboxylic acid (TCH-1116) inhibited O(2)(-) (superoxide anion) generation, which w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3afb48668745807b94e6296738129e
https://doi.org/10.1016/j.ejphar.2012.02.016

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Signaling mechanisms of inhibition of phospholipase D activation by CHS-111 in formyl peptide-stimulated neutrophils

Autor: Ruey-Hseng Lin, Ling-Chu Chang, Li-Jiau Huang, Chi-Sen Chang, Tai-Hung Huang, Jih-Pyang Wang, Pin-Wen Lee, Mei-Feng Hsu, Ya-Ru Tsai

Publikováno v: Biochemical Pharmacology. 81:269-278

A selective phospholipase D (PLD) inhibitor 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) inhibited the O(2)(-) generation and cell migration but not degranulation in formyl-Met-Leu-Phe (fMLP)-stimulated rat neutrophils. A novel benzyl indazole comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d122c6865de52db38ff68680b0224fc
https://doi.org/10.1016/j.bcp.2010.10.007

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Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-α production

Autor: Jih-Pyang Wang, Chien Shu Chen, Fong-Chi Cheng, Chiung-Hua Huang, Chen-Ming Tan, Ji-Wang Chern, Ling-Chu Chang

Publikováno v: Bioorganic & Medicinal Chemistry. 18:597-604

In the present study we have discovered compound 1 , a benzo[1.3.2]dithiazolium ylide-based compound, as a new prototype dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX). Compound 1 was initially discovered as a COX-2 inhibitor, resu

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https://doi.org/10.1016/j.bmc.2009.12.008

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Inhibition of superoxide anion generation by CHS-111 via blockade of the p21-activated kinase, protein kinase B/Akt and protein kinase C signaling pathways in rat neutrophils

Autor: Li-Jiau Huang, Sheng-Chu Kuo, Ruey-Hseng Lin, Ling-Chu Chang, Chi-Sen Chang, Jih-Pyang Wang

Publikováno v: European Journal of Pharmacology. 615:207-217

In formyl-Met-Leu-Phe (fMLP)-stimulated rat neutrophils, 2-benzyl-3-(4-hydroxymethylphenyl)indazole (CHS-111) inhibited superoxide anion (O(2)(-)) generation, which was not mediated by scavenging the generated O(2)(-) or by a cytotoxic effect, and at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b5f77468e1c90cdacb72f4633a2ec4
https://doi.org/10.1016/j.ejphar.2009.04.050

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The influence of acetylshikonin, a natural naphthoquinone, on the production of leukotriene B4 and thromboxane A2 in rat neutrophils

Autor: Ling-Chu Chang, Jih-Pyang Wang, Mei-Feng Hsu, Sheng-Chu Kuo, Li-Jiau Huang, Min-Chi Lu, Hsiao-Yun Lee

Publikováno v: European Journal of Pharmacology. 607:234-243

Both A23187 and formyl-Met-Leu-Phe (fMLP) induced the release of arachidonic acid and the production of thromboxane B(2) and leukotriene B(4) from rat neutrophils that were inhibited by acetylshikonin in a concentration-dependent manner. Acetylshikon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c5ad0a31e6527177c98369b783b0a1
https://doi.org/10.1016/j.ejphar.2009.02.005

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Inhibition of nitric oxide production by the carbazole compound LCY-2-CHO via blockade of activator protein-1 and CCAAT/enhancer-binding protein activation in microglia

Autor: Ling-Chu Chang, Ruey-Hseng Lin, Chi-Sen Chang, Jih-Pyang Wang, Chun-Jung Chen, Lo-Ti Tsao, Li-Jiau Huang, Sheng-Chu Kuo

Publikováno v: Biochemical Pharmacology. 76:507-519

Excessive nitric oxide (NO) production by activated microglia plays a critical role in neurodegenerative disorders. In this study, we found that 9-(2-chlorobenyl)-9H-carbazole-3-carbaldehyde (LCY-2-CHO) suppressed the NO production in lipopolysacchar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed55b16772c05eee26e2e1c308e984fa
https://doi.org/10.1016/j.bcp.2008.06.002

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