Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Jih-Hwa Guh"'
Autor:
Maryam Rachmawati Sumitra, Lung-Ching Chen, Wei-Chen Tsai, Muhamad Ansar, Bashir Lawal, Ntlotlang Mokgautsi, Jih-Hwa Guh, Alexander T.H Wu, Hsu-Shan Huang
Publikováno v:
Arabian Journal of Chemistry, Vol 17, Iss 1, Pp 105423- (2024)
Tetraheterocyclic compounds, derived from natural sources and contemporary pharmaceuticals, have shown promise as multitarget therapeutic agents. However, their mechanisms of action remain partially understood. In this study, we synthesized a series
Externí odkaz:
https://doaj.org/article/47e48b334a9b414aa185b8989a82291c
Autor:
Ya-Fen Hsu, Fan-Lu Kung, Tzu-En Huang, Yi-Ning Deng, Jih-Hwa Guh, Paolo Marchetti, Elena Marchesi, Daniela Perrone, Maria Luisa Navacchia, Lih-Ching Hsu
Publikováno v:
Molecules, Vol 28, Iss 5, p 2358 (2023)
Hepatocellular carcinoma is the third most common cause of cancer-related death according to the International Agency for Research on Cancer. Dihydroartemisinin (DHA), an antimalarial drug, has been reported to exhibit anticancer activity but with a
Externí odkaz:
https://doaj.org/article/ff24007f53004f1a8586ea1f00420e9a
Autor:
Hao-Cheng Weng, Chieh-Ju Sung, Jui-Ling Hsu, Wohn-Jenn Leu, Jih-Hwa Guh, Fan-Lu Kung, Lih-Ching Hsu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Breast cancer is the most prevalent cancer and the second leading cause of cancer death in women. Cisplatin is a commonly used chemotherapeutic drug for breast cancer treatment. Owing to serious side effects, the combination of cisplatin with other d
Externí odkaz:
https://doaj.org/article/87867dc881c5485886ec66bb7c2bddb4
Autor:
Tsung-Chih Chen, Jih-Hwa Guh, Hui-Wen Hsu, Chun-Liang Chen, Chia-Chung Lee, Chia-Lun Wu, Yu-Ru Lee, Jing-Jer Lin, Dah-Shyong Yu, Hsu-Shan Huang
Publikováno v:
Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 2864-2881 (2019)
Several anthrapyrazolone derivatives derived from 7-chloroanthra[1,9-cd]pyrazol-6(2H)-one and 7-chloro-2-(2-hydroxyethyl)anthra[1,9-cd] pyrazol-6(2H)-one have been prepared by the addition or substitution nucleophilic reactions and further transforme
Externí odkaz:
https://doaj.org/article/07c8dfd9976e42c8b028a480878eaa79
Autor:
Tsung-Chih Chen, Dah-Shyong Yu, Shiag-Jiun Chen, Chun-Liang Chen, Chia-Chung Lee, Ying-Yu Hsieh, Lien-Cheng Chang, Jih-Hwa Guh, Jing-Jer Lin, Hsu-Shan Huang
Publikováno v:
Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 4348-4364 (2019)
Several 9-chloro-11H-indeno[1,2-c]quinolin-11-one derivatives have been designed which is replacing side chains with different groups containing oxygen, nitrogen or sulfur atoms. Substitution of C-6 on the starting structure, 6,9-dichloro-11H-indeno[
Externí odkaz:
https://doaj.org/article/d45f804a2ed94bd5bebf658de88326e6
Publikováno v:
Molecules, Vol 27, Iss 22, p 8106 (2022)
Tumor cells rely on aerobic glycolysis to support growth and survival, thus require more glucose supply. Glucose transporters GLUTs, primarily GLUT1, are overexpressed in various cancers. Targeting GLUTs has been regarded as a promising anticancer st
Externí odkaz:
https://doaj.org/article/02764636511146bc83fe0dca96bfa076
Autor:
Tzu-En Huang, Yi-Ning Deng, Jui-Ling Hsu, Wohn-Jenn Leu, Elena Marchesi, Massimo L. Capobianco, Paolo Marchetti, Maria Luisa Navacchia, Jih-Hwa Guh, Daniela Perrone, Lih-Ching Hsu
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy in adults and accounts for 85–90% of all primary liver cancer. Based on the estimation by the International Agency for Research on Cancer in 2018, liver cancer is the fourth
Externí odkaz:
https://doaj.org/article/311890ab56b4453cad17527f699ccc44
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Combination therapies that display cancer-killing activities through either coexistent targeting of several cellular factors or more efficient suppression of a specific pathway are generally used in cancer treatment. Sildenafil, a specific phosphodie
Externí odkaz:
https://doaj.org/article/dd23ac1a86c643c987fc66a50d488968
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death in women. Hormone receptor-positive breast cancer is usually subjected to hormone therapy, while triple-negative breast cancer is more formidable and pos
Externí odkaz:
https://doaj.org/article/3a50f21e63c74ef78a9a85f4b0c12b5b
Publikováno v:
Molecules, Vol 26, Iss 19, p 5967 (2021)
Non-small cell lung cancer (NSCLC), an aggressive subtype of pulmonary carcinomas with high mortality, accounts for 85% of all lung cancers. Drug resistance and high recurrence rates impede the chemotherapeutic effect, making it urgent to develop new
Externí odkaz:
https://doaj.org/article/0770d624bb1d4ed394ad37c29e9bf129