Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jifang Yan"'
Autor:
Gongchen Zhang, Chenyu Zhu, Xiaohan Chen, Jifang Yan, Dongyu Xue, Zixuan Wei, Guohui Chuai, Qi Liu
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 21, Iss 6, Pp 1237-1245 (2023)
Base editing technology is being increasingly applied in genome engineering, but the current strategy for designing guide RNAs (gRNAs) relies substantially on empirical experience rather than a dependable and efficient in silico design. Furthermore,
Externí odkaz:
https://doaj.org/article/e9f9ac4390eb4669b80c2ce1bb4bcbc0
Autor:
Guohui Chuai, Hanhui Ma, Jifang Yan, Ming Chen, Nanfang Hong, Dongyu Xue, Chi Zhou, Chenyu Zhu, Ke Chen, Bin Duan, Feng Gu, Sheng Qu, Deshuang Huang, Jia Wei, Qi Liu
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-18 (2018)
Abstract A major challenge for effective application of CRISPR systems is to accurately predict the single guide RNA (sgRNA) on-target knockout efficacy and off-target profile, which would facilitate the optimized design of sgRNAs with high sensitivi
Externí odkaz:
https://doaj.org/article/2104725807714c1d88f2726e3334760e
Autor:
Guohui Chuai, Fayu Yang, Jifang Yan, Yanan Chen, Qin Ma, Chi Zhou, Chenyu Zhu, Feng Gu, Qi Liu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Externí odkaz:
https://doaj.org/article/ac217e0487104bb680753fda2e4db415
Autor:
Gongchen Zhang, Chenyu Zhu, Xiaohan Chen, Jifang Yan, Dongyu Xue, Zixuan Wei, Guohui Chuai, Qi Liu
Publikováno v:
Genomics, proteomicsbioinformatics.
Base editing technology is being increasingly applied in genome engineering, but the current strategy for designing guide RNA (gRNA) relies substantially on empirical experience rather than a dependable and efficient in silico design. Furthermore, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d75b55fd2aabe8c51d3f785fb950ca
https://pubmed.ncbi.nlm.nih.gov/35792260
https://pubmed.ncbi.nlm.nih.gov/35792260
Publikováno v:
Nucleic Acids Research
Systematic evaluation of genome-wide Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) off-target profiles is a fundamental step for the successful application of the CRISPR system to clinical therapies. Many experimental techniques
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023169ee9b334c5944fac12bfe54a444
https://pubmed.ncbi.nlm.nih.gov/33137817
https://pubmed.ncbi.nlm.nih.gov/33137817
Autor:
Nanfang Hong, Chi Zhou, Sheng Qu, Qi Liu, Chenyu Zhu, Guohui Chuai, Feng Gu, Chen Ke, Bin Duan, Deshuang Huang, Ming Chen, Jifang Yan, Dongyu Xue, Jia Wei, Hanhui Ma
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-18 (2018)
Genome Biology
Genome Biology
A major challenge for effective application of CRISPR systems is to accurately predict the single guide RNA (sgRNA) on-target knockout efficacy and off-target profile, which would facilitate the optimized design of sgRNAs with high sensitivity and sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea357c7a9f0fb53ce8ad2ab37fb279c
http://link.springer.com/article/10.1186/s13059-018-1459-4
http://link.springer.com/article/10.1186/s13059-018-1459-4
Autor:
Jifang Yan1, Guohui Chuai1, Tao Qi1, Fangyang Shao2, Chi Zhou1, Chenyu Zhu1, Jing Yang1, Yifei Yu1, Cong Shi2, Ning Kang3, Yuan He2 drheyuan@tongji.edu.cn, Qi Liu1 qiliu@tongji.edu.cn
Publikováno v:
BMC Genomics. 2017 Suppl 1, Vol. 18, p1-5. 5p. 1 Graph.
Autor:
Jia Wei, Han Xu, Chi Zhou, Jifang Yan, Chenyu Zhu, Guohui Chuai, Qi Liu, Chao Zhang, Jing Yang, Feng Gu
Publikováno v:
Briefings in Bioinformatics. 19:721-724
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-based gene editing has been widely implemented in various cell types and organisms. A major challenge in the effective application of the CRISPR system is the need to design highly ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3777d4fb4d1704ff3e097c56e12f84
https://doi.org/10.1093/bib/bbx001
https://doi.org/10.1093/bib/bbx001
Autor:
Guohui Chuai, Hanhui Ma, Jifang Yan, Chen, Ming, Nanfang Hong, Dongyu Xue, Zhou, Chi, Chenyu Zhu, Chen, Ke, Duan, Bin, Gu, Feng, Qu, Sheng, Deshuang Huang, Wei, Jia, Liu, Qi
Supplementary notes. (PDF 339 kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131e1fe1d4f74eb4aec56678b75907a0
Publikováno v:
Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 33(10)
CRISPR-based genome editing has been widely implemented in various cell types. In-silico single guide RNA (sgRNA) design is a key step for successful gene editing using CRISPR system. Continuing efforts are made to refine in-silico sgRNA design with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0e22258564d4ea2fe27ae1aab1fb2903
https://pubmed.ncbi.nlm.nih.gov/29082722
https://pubmed.ncbi.nlm.nih.gov/29082722