Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Jiesheng, Kang"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:446-451
Abuse of the common anti-diarrheal loperamide is associated with QT interval prolongation as well as development of the potentially fatal arrhythmia torsades de pointes. The mechanism underlying this cardiotoxicity is high affinity inhibition of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc46fd2ce619143a94f4c900ecad85e
https://doi.org/10.1016/j.bmcl.2017.12.020
https://doi.org/10.1016/j.bmcl.2017.12.020
Autor:
Jiesheng Kang1, Xiao-Liang Chen1, Reynolds, William P.1, Rampe, David1 david.rampe@sanofi-aventis.com
Publikováno v:
Clinical & Experimental Pharmacology & Physiology. Dec2007, Vol. 34 Issue 12, p1313-1316. 4p. 2 Graphs.
Publikováno v:
Journal of Applied Toxicology. 37:445-453
Inhibition of the human ether-a-go-go-related gene (hERG) K+ channel by drugs leads to QT prolongation on the electrocardiogram and can result in serious cardiac arrhythmia. For this reason, screening of drugs on hERG is mandatory during the drug dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f31da1b3cd5caba6cf6e361605a365d
https://doi.org/10.1002/jat.3377
https://doi.org/10.1002/jat.3377
Publikováno v:
ASSAY and Drug Development Technologies. 12:352-360
Human stem cell-derived cardiomyocytes provide a cellular model for the study of electrophysiology in the human heart and are finding a niche in the field of safety pharmacology for predicting proarrhythmia. The cardiac L-type Ca2+ channel is an impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763b2bc4d2cd4e37c311bb85956a95d7
https://doi.org/10.1089/adt.2014.596
https://doi.org/10.1089/adt.2014.596
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 389(10)
Loperamide is a μ-opioid receptor agonist commonly used to treat diarrhea and often available as an over-the-counter medication. Recently, numerous reports of QRS widening accompanied by dramatic QT interval prolongation, torsades de pointe arrhythm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602ad69a0141232658e8af5c9450c92c
https://pubmed.ncbi.nlm.nih.gov/27530870
https://pubmed.ncbi.nlm.nih.gov/27530870
Publikováno v:
Journal of applied toxicology : JAT. 37(4)
Inhibition of the human ether-a-go-go-related gene (hERG) K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e8cd041e34b569ee4bd4c78a17c943c0
https://pubmed.ncbi.nlm.nih.gov/27553911
https://pubmed.ncbi.nlm.nih.gov/27553911
Autor:
Haoyu Zeng, Jiesheng Kang
Publikováno v:
ADME-Enabling Technologies in Drug Design and Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eedbcfab779463eb8ebbfe4b972b5e70
https://doi.org/10.1002/9781118180778.ch32
https://doi.org/10.1002/9781118180778.ch32
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 341:510-517
Human stem cell-derived cardiomyocytes provide new models for studying the ion channel pharmacology of human cardiac cells for both drug discovery and safety pharmacology purposes. However, detailed pharmacological characterization of ion channels in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cde526b606c59d6c0a676821c9dceea
https://doi.org/10.1124/jpet.112.192609
https://doi.org/10.1124/jpet.112.192609
Autor:
Xin Chen, Poli Gregory B, Joseph T. Tsay, Jiesheng Kang, Ying Zhang, Anne Minnich, Keith Sides, Qingping Wang, Yong Mi Choi-Sledeski, Patrick Wai-Kwok Shum, Guyan Liang, Vasant Kumar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1606-1610
Tropanylamide was investigated as a possible scaffold for β-tryptase inhibitors with a basic benzylamine P1 group and a substituted thiophene P4 group. Comparing to piperidinylamide, the tropanylamide scaffold is much more rigid, which presents less
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11005196f65f43ed0cb5d4f3f5282312
https://doi.org/10.1016/j.bmcl.2011.12.127
https://doi.org/10.1016/j.bmcl.2011.12.127
Autor:
Xiaoyou Ying, Harry Meng, Junzhi Ji, James Cao, Jiesheng Kang, William F. Reynolds, David Rampe
Publikováno v:
Toxicology Letters. 208:62-68
Mephedrone (4-methylmethcathinone) is a new and popular drug of abuse widely available on the Internet and still legal in some parts of the world. Clinical reports are now emerging suggesting that the drug displays sympathomimetic toxicity on the car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb573877cd9817015305927833156c1e
https://doi.org/10.1016/j.toxlet.2011.10.010
https://doi.org/10.1016/j.toxlet.2011.10.010