Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Jielin Xu"'
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Amyotrophic Lateral Sclerosis (ALS) is a devastating, immensely complex neurodegenerative disease by lack of effective treatments. We developed a network medicine methodology via integrating human brain multi-omics data to prioritize drug ta
Externí odkaz:
https://doaj.org/article/5c2c7a5d865c4837b4a0266377e13533
Autor:
Chang Su, Yu Hou, Jielin Xu, Zhenxing Xu, Manqi Zhou, Alison Ke, Haoyang Li, Jie Xu, Matthew Brendel, Jacqueline R. M. A. Maasch, Zilong Bai, Haotan Zhang, Yingying Zhu, Molly C. Cincotta, Xinghua Shi, Claire Henchcliffe, James B. Leverenz, Jeffrey Cummings, Michael S. Okun, Jiang Bian, Feixiong Cheng, Fei Wang
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-22 (2024)
Abstract Parkinson’s disease (PD) is a serious neurodegenerative disorder marked by significant clinical and progression heterogeneity. This study aimed at addressing heterogeneity of PD through integrative analysis of various data modalities. We a
Externí odkaz:
https://doaj.org/article/c98b774780634551a2636756a95523ae
Publikováno v:
Giant, Vol 18, Iss , Pp 100281- (2024)
To enhance the degradation rate of poly (butylene adipate-co-terephthalate) (PBAT) in the natural environment and to investigate the effect of modified monomers on the molding and structure of copolyester fibers, a series of isosorbide modified PBAT
Externí odkaz:
https://doaj.org/article/4a8e3fc26bce4abe8542dad569792c55
Autor:
Jiansong Fang, Pengyue Zhang, Quan Wang, Chien-Wei Chiang, Yadi Zhou, Yuan Hou, Jielin Xu, Rui Chen, Bin Zhang, Stephen J. Lewis, James B. Leverenz, Andrew A. Pieper, Bingshan Li, Lang Li, Jeffrey Cummings, Feixiong Cheng
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-23 (2022)
Abstract Background Genome-wide association studies (GWAS) have identified numerous susceptibility loci for Alzheimer’s disease (AD). However, utilizing GWAS and multi-omics data to identify high-confidence AD risk genes (ARGs) and druggable target
Externí odkaz:
https://doaj.org/article/afadea9add5a4dca9d53dbb246f34925
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 1, Pp n/a-n/a (2023)
Abstract Introduction Alzheimer's disease (AD) is a neurodegenerative disorder involving interactions between different cell types in the brain. Previous single‐cell and bulk expression Alzheimer's studies have reported conflicting findings about t
Externí odkaz:
https://doaj.org/article/09568f0d75e14ef69e63176b13ac2e20
Autor:
Yadi Zhou, Jielin Xu, Yuan Hou, James B. Leverenz, Asha Kallianpur, Reena Mehra, Yunlong Liu, Haiyuan Yu, Andrew A. Pieper, Lara Jehi, Feixiong Cheng
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-19 (2021)
Abstract Background Dementia-like cognitive impairment is an increasingly reported complication of SARS-CoV-2 infection. However, the underlying mechanisms responsible for this complication remain unclear. A better understanding of causative processe
Externí odkaz:
https://doaj.org/article/04b5b921344f4bb38da1729930c029e2
Autor:
Chirag Gupta, Jielin Xu, Ting Jin, Saniya Khullar, Xiaoyu Liu, Sayali Alatkar, Feixiong Cheng, Daifeng Wang
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 7, p e1010287 (2022)
Dysregulation of gene expression in Alzheimer's disease (AD) remains elusive, especially at the cell type level. Gene regulatory network, a key molecular mechanism linking transcription factors (TFs) and regulatory elements to govern gene expression,
Externí odkaz:
https://doaj.org/article/3cabb5e33a14415a8e48b2d3c256556f
Autor:
Yadi Zhou, Jielin Xu, Yuan Hou, Lynn Bekris, James B. Leverenz, Andrew A. Pieper, Jeffrey Cummings, Feixiong Cheng
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Recent advances in generating massive single‐cell/nucleus transcriptomic data have shown great potential for facilitating the identification of cell type–specific Alzheimer's disease (AD) pathobiology and drug‐target disco
Externí odkaz:
https://doaj.org/article/c26e94dac07f4354bcf3ad52f50737d6
Autor:
Jielin Xu, Yuan Hou, Yadi Zhou, Lynn M. Bekris, Andrew A. Pieper, Jeffrey Cummings, James B. Leverenz, Feixiong Cheng
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf84e27bef4ee9140c85232af110eb20
https://doi.org/10.1002/alz.066647
https://doi.org/10.1002/alz.066647
Autor:
Feixiong Cheng, Yuan Hou, Yadi Zhou, Jielin Xu, Lynn M. Bekris, Justin D. Lathia, Andrew A. Pieper, James B. Leverenz, Jeffrey Cummings
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::808d6dcfca88be1d64b64c552c37a129
https://doi.org/10.1002/alz.066649
https://doi.org/10.1002/alz.066649