Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Jiekai, Chen"'
Autor:
Yuan Yu, Kaixuan Lin, Haoyu Wu, Mingli Hu, Xuejie Yang, Jie Wang, Johannes Grillari, Jiekai Chen
Publikováno v:
Cell Regeneration, Vol 13, Iss 1, Pp 1-13 (2024)
Abstract The COVID-19 pandemic has caused a global health crisis and significant social economic burden. While most individuals experience mild or non-specific symptoms, elderly individuals are at a higher risk of developing severe symptoms and life-
Externí odkaz:
https://doaj.org/article/3b97c559578a4a9e82bf39485946df79
Autor:
Yongli Shan, Yanqi Zhang, Yanxing Wei, Cong Zhang, Huaisong Lin, Jiangping He, Junwei Wang, Wenjing Guo, Heying Li, Qianyu Chen, Tiancheng Zhou, Qi Xing, Yancai Liu, Jiekai Chen, Guangjin Pan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Nucleoli are fundamentally essential sites for ribosome biogenesis in cells and formed by liquid-liquid phase separation (LLPS) for a multilayer condensate structure. How the nucleoli integrity is maintained remains poorly understood. Here,
Externí odkaz:
https://doaj.org/article/57e4c749c6af4bab8b295c8b88926ab3
Autor:
Jin Ming, Lihui Lin, Jiajun Li, Linlin Wu, Shicai Fang, Tao Huang, Yu Fu, Dong Liu, Wenhui Zhang, Chen Li, Yongzheng Yang, Yi Huang, Yue Qin, Junqi Kuang, Xingnan Huang, Liman Guo, Xiaofei Zhang, Jing Liu, Jiekai Chen, Chengchen Zhao, Bo Wang, Duanqing Pei
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Cell fate decisions remain poorly understood at the molecular level. Embryogenesis provides a unique opportunity to analyze molecular details associated with cell fate decisions. Works based on model organisms have provided a conceptual fram
Externí odkaz:
https://doaj.org/article/ffdc847766ec44819944f9a9f82f028c
Autor:
Airu Zhu, Liang Zhou, Zhao Chen, Dongdong Liu, Huijian Feng, Baomei Cai, Xinwen Chen, Jincun Zhao, Jingxian Zhao, Jiekai Chen, Manshu Li, Jiangping He
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e38688- (2024)
The vastly spreading COVID-19 pneumonia is caused by SARS-CoV-2. Lymphopenia and cytokine levels are tightly associated with disease severity. However, virus-induced immune dysregulation at cellular and molecular levels remains largely undefined. Her
Externí odkaz:
https://doaj.org/article/6e7925febf3a49e8a2bbb410811577ae
Autor:
Dongwei Li, Ling Luo, Lin Guo, Chuman Wu, Ran Zhang, Yuling Peng, Menghua Wu, Junqi Kuang, Yan Li, Yudan Zhang, Jun Xie, Wenxiu Xie, Rui Mao, Gang Ma, Xiuling Fu, Jiekai Chen, Andrew P. Hutchins, Duanqing Pei
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Background c-Jun is a proto-oncogene functioning as a transcription factor to activate gene expression under many physiological and pathological conditions, particularly in somatic cells. However, its role in early embryonic development rema
Externí odkaz:
https://doaj.org/article/52eb21dc651741be97c67dfe5c8f7c33
Autor:
Fangfang Qu, Wenjia Li, Jian Xu, Ruifang Zhang, Jincan Ke, Xiaodie Ren, Xiaogao Meng, Lexin Qin, Jingna Zhang, Fangru Lu, Xin Zhou, Xi Luo, Zhen Zhang, Minhan Wang, Guangming Wu, Duanqing Pei, Jiekai Chen, Guizhong Cui, Shengbao Suo, Guangdun Peng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Mammalian embryos exhibit sophisticated cellular patterning that is intricately orchestrated at both molecular and cellular level. It has recently become apparent that cells within the animal body display significant heterogeneity, both in t
Externí odkaz:
https://doaj.org/article/eacd895166b546c099665ce9ce153bf8
Autor:
Yanan Liu, Longmiao Hu, Zhengzhen Wu, Kun Yuan, Guangliang Hong, Zhengke Lian, Juanjuan Feng, Na Li, Dali Li, Jiemin Wong, Jiekai Chen, Mingyao Liu, Jiangping He, Xiufeng Pang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Immunotherapy has become established as major treatment modality for multiple types of solid tumors, including colorectal cancer. Identifying novel immunotherapeutic targets to enhance anti-tumor immunity and sensitize current immune checkpo
Externí odkaz:
https://doaj.org/article/cfd906eb22b048cdb7a03488a79f3fcd
Autor:
Bo Wang, Chen Li, Jin Ming, Linlin Wu, Shicai Fang, Yi Huang, Lihui Lin, He Liu, Junqi Kuang, Chengchen Zhao, Xingnan Huang, Huijian Feng, Jing Guo, Xuejie Yang, Liman Guo, Xiaofei Zhang, Jiekai Chen, Jing Liu, Ping Zhu, Duanqing Pei
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Cell fate decision involves rewiring of the genome, but remains poorly understood at the chromatin level. Here, we report that chromatin remodeling complex NuRD participates in closing open chromatin in the early phase of somatic reprogrammi
Externí odkaz:
https://doaj.org/article/4cb7569c25cc418daef3997fe87ba465
Autor:
Zhen-Dong Zhong, Ying-Yuan Xie, Hong-Xuan Chen, Ye-Lin Lan, Xue-Hong Liu, Jing-Yun Ji, Fu Wu, Lingmei Jin, Jiekai Chen, Daniel W. Mak, Zhang Zhang, Guan-Zheng Luo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Direct RNA sequencing using nanopore platform can be used to detect N6-methyladenosine (m6A) modifications on mRNAs. Here the authors systematically compare tools used for m6A detection from nanopore direct sequencing.
Externí odkaz:
https://doaj.org/article/da7983b5010a43419a87347461c7e37b
Autor:
Lingmei Jin, Jiangping He, Huijian Feng, Sa Li, He Liu, Hongzhi Dong, MingLi Hu, Junju Huang, Haoyu Wu, Jiekai Chen, Ling Qi, Kaixin Wu
Publikováno v:
Cell Death and Disease, Vol 14, Iss 3, Pp 1-10 (2023)
Abstract Deficiency of the histone H3K9 methyltransferase SETDB1 induces RIPK3-dependent necroptosis in mouse embryonic stem cells (mESCs). However, how necroptosis pathway is activated in this process remains elusive. Here we report that the reactiv
Externí odkaz:
https://doaj.org/article/c11f85437c8b4b82981f4369fcc3097c