Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jiejun Wen"'
Autor:
Yi Wang, Linnan Bai, Jiejun Wen, Fangfei Zhang, Sijie Gu, Feng Wang, Jianyong Yin, Niansong Wang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
IntroductionCKD-induced pathological cardiac remodeling is characterized by myocardial hypertrophy and cardiac fibrosis. The available therapeutic options are limited, it is thus urgently needed to identify novel therapeutic targets. Renalase (RNLS)
Externí odkaz:
https://doaj.org/article/1d4af785d1474018a00bfa13f6858200
Autor:
Xiaomei Li, Jiejun Wen, Yang Dong, Qunzi Zhang, Jian Guan, Feng Liu, Ting Zhou, Ze Li, Ying Fan, Niansong Wang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-15 (2021)
Abstract Immune and inflammatory factors have emerged as key pathophysiological mechanisms in the progression of diabetic renal injury. Noncanonical Wnt5a signaling plays an essential role in obesity- or diabetes-induced metabolic dysfunction and inf
Externí odkaz:
https://doaj.org/article/efeae79efecd424ca644dc754a0d6048
Autor:
Ying Fan, Yang Fei, Li Zheng, Jiemin Wang, Wenzhen Xiao, Jiejun Wen, Yanping Xu, Yiyun Wang, Li He, Jian Guan, Jia Wei, John Cijiang He, Niansong Wang
Publikováno v:
Cellular Physiology and Biochemistry, Vol 48, Iss 1, Pp 63-74 (2018)
Background/Aims: Glomerular endothelial cell injury plays a crucial role in the development of diabetic nephropathy (DN). CD146, an endothelial marker, was shown to increase in chronic kidney disease (CKD), but its role in DN remains unknown. We aim
Externí odkaz:
https://doaj.org/article/8b2382207552429586c845a99d07d0c6
Autor:
Ying Fan, Jing Zhang, Wenzhen Xiao, Kyung Lee, Zhengzhe Li, Jiejun Wen, Li He, Dingkun Gui, Rui Xue, Guihua Jian, Xiaohua Sheng, John Cijiang He, Niansong Wang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract We previously reported a critical role of reticulon (RTN) 1A in mediating endoplasmic reticulum (ER) stress in kidney tubular cells and the expression of RTN1A correlates with the renal function and the severity of kidney injury in patients
Externí odkaz:
https://doaj.org/article/6552ee6c30a348679ffdcd2eba99d737
Autor:
Yang Dong, Qunzi Zhang, Jiejun Wen, Teng Chen, Li He, Yiyun Wang, Jianyong Yin, Rui Wu, Rui Xue, Shiqi Li, Ying Fan, Niansong Wang
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Ischemia reperfusion injury (IRI) is one of the most common causes of acute kidney injury (AKI). However, the pathogenesis and biomarkers predicting the progression of IRI-induced AKI to chronic kidney disease (CKD) remain unclear. A side-by-side com
Externí odkaz:
https://doaj.org/article/bbc5adbcc9814b9caa512187bac1b093
Autor:
Jianyong Yin, Xiaomei Li, Jiejun Wen, Niansong Wang, Yang Dong, Qunzi Zhang, Wenjun Lin, Feng Liu, Teng Chen, Ying Fan
Publikováno v:
Biochemical and Biophysical Research Communications. 557:166-173
Background Renal ischemia reperfusion injury (IRI) has become a growing concern in clinical practice with high morbidity and mortality rates. There is currently no effective prophylactic regimen available to prevent its occurrence and to improve its
Autor:
Ting Zhou, Yang Dong, Jian Guan, Feng Liu, Li He, Yang Fei, Jiejun Wen, Ze Li, Qunzi Zhang, Xiaomei Li, Niansong Wang, Ying Fan
Publikováno v:
The FASEB Journal. 34:7500-7519
Mitochondrial abnormalities play critical roles in diabetic tubular injury progression. Dipeptidyl peptidase-4 (DPP4) inhibitors are widely used antihyperglycemic agents that exert renal protective and positive effects against mitochondrial dysfuncti
Publikováno v:
Renal Failure; Dec2022, Vol. 44 Issue 1, p473-481, 9p, 1 Black and White Photograph, 3 Graphs
Autor:
Xianfeng Wu, Xiaomei Li, Yang Fei, Niansong Wang, Jiejun Wen, Ying Fan, Wenjun Lin, Yang Dong, Qunzi Zhang, Tao Xu, Junnan Wu
Publikováno v:
Nutrition. :111376
Objectives Acute kidney injury (AKI) is a severe complication of rhabdomyolysis that significantly increases mortality. Unfortunately, the therapeutic approach is limited. Inflammation plays a critical role in the pathogenesis of rhabdomyolysis-induc
Autor:
John Cijiang He, Rui Xue, Yiyun Wang, Yang Dong, Shiqi Li, Teng Chen, Wenzhen Xiao, Ying Fan, Jiejun Wen, Li He, Niansong Wang, Liyang Zheng
Publikováno v:
Oncotarget
Hyperuricemia contributes to kidney tubular injury and kidney fibrosis. However, the underlying mechanism remains unclear. Here we examined the role of RTN1A, a novel endoplasmic reticulum (ER)-associated protein and ER stress in hyperuricemic nephro