Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Jiehui Deng"'
Autor:
Hyejin Choi, Jiehui Deng, Shuai Li, Tarik Silk, Lauren Dong, Elliott J. Brea, Sean Houghton, David Redmond, Hong Zhong, Jonathan Boiarsky, Esra A. Akbay, Paul D. Smith, Taha Merghoub, Kwok-Kin Wong, Jedd D. Wolchok
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 806-819.e5 (2019)
Summary: KRAS is one of the driver oncogenes in non-small-cell lung cancer (NSCLC) but remains refractory to current modalities of targeted pathway inhibition, which include inhibiting downstream kinase MEK to circumvent KRAS activation. Here, we sho
Externí odkaz:
https://doaj.org/article/efa987c04f3a452490755f945bd7a287
Publikováno v:
Cell Reports, Vol 6, Iss 6, Pp 992-999 (2014)
S1PR1 signaling has been shown to restrain the number and function of regulatory T (Treg) cells in the periphery under physiological conditions and in colitis models, but its role in regulating tumor-associated T cells is unknown. Here, we show that
Externí odkaz:
https://doaj.org/article/a7d6c5ba55014df592ca15df7e1d9566
Autor:
Chunmei Yang, Heehyoung Lee, Veronica Jove, Jiehui Deng, Wang Zhang, Xueli Liu, Stephen Forman, Thanh H Dellinger, Mark Wakabayashi, Hua Yu, Sumanta Pal
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54029 (2013)
Several previous studies have identified a strong association between T-cell infiltration and clinical outcome in ovarian cancer. The role of B-cells remains controversial, however.Forty-nine paraffin-embedded omental specimens derived from patients
Externí odkaz:
https://doaj.org/article/c71990539bd441f4979b87d244d16e83
Autor:
Shasha Li, Saul J Priceman, Hong Xin, Wang Zhang, Jiehui Deng, Yong Liu, Jiabin Huang, Wenshan Zhu, Mingjie Chen, Wei Hu, Xiaomin Deng, Jian Zhang, Hua Yu, Guangyuan He
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81657 (2013)
Signal transducer and activator of transcription-3 (STAT3) is critical for cancer progression by regulating tumor cell survival, proliferation, and angiogenesis. Herein, we investigated the regulation of STAT3 activation and the therapeutic effects o
Externí odkaz:
https://doaj.org/article/f64d454aae6f4eb190387fbbebf84325
Autor:
Chunmei Yang, Heehyoung Lee, Sumanta Pal, Veronica Jove, Jiehui Deng, Wang Zhang, Dave S B Hoon, Mark Wakabayashi, Stephen Forman, Hua Yu
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64159 (2013)
The role of B cells in cancer and the underlying mechanisms remain to be further explored. Here, we show that tumor-associated B cells with activated STAT3 contribute to tumor development by promoting tumor angiogenesis. B cells with or without Stat3
Externí odkaz:
https://doaj.org/article/56686bb949724812a707feb27e59d8af
Autor:
Victor R. Adorno Febles, Yuan Hao, Aarif Ahsan, Jiansheng Wu, Yingzhi Qian, Hua Zhong, Stacy Loeb, Danil V. Makarov, Herbert Lepor, James Wysock, Samir S. Taneja, William C. Huang, Daniel J. Becker, Arjun V. Balar, Jonathan Melamed, Fang‐Ming Deng, Qinghu Ren, Donald Kufe, Kwok‐Kin Wong, Dennis O. Adeegbe, Jiehui Deng, David R. Wise
Publikováno v:
The Prostate. 83:840-849
Autor:
Kayla Guidry, Varshini Vasudevaraja, Kristen Labbe, Hussein Mohamed, Jonathan Serrano, Brett W. Guidry, Michael DeLorenzo, Hua Zhang, Jiehui Deng, Soumyadip Sahu, Christina Almonte, Andre L. Moreira, Aristotelis Tsirigos, Thales Papagiannakopoulos, Harvey Pass, Matija Snuderl, Kwok-Kin Wong
Publikováno v:
Clinical Cancer Research. 28:3824-3835
Purpose: Lung adenocarcinoma (LUAD) is a clinically heterogeneous disease, which is highlighted by the unpredictable recurrence in low-stage tumors and highly variable responses observed in patients treated with immunotherapies, which cannot be expla
Autor:
Jiehui Deng, David H. Peng, David Fenyo, Hao Yuan, Alfonso Lopez, Daniel S. Levin, Mary Meynardie, Mari Quinteros, Michela Ranieri, Soumyadip Sahu, Sally C. M. Lau, Elaine Shum, Vamsidhar Velcheti, Salman R. Punekar, Natasha Rekhtman, Catríona M. Dowling, Vajira Weerasekara, Yun Xue, Hongbin Ji, Yik Siu, Drew Jones, Aaron N. Hata, Takeshi Shimamura, John T. Poirier, Charles M Rudin, Takamitsu Hattori, Shohei Koide, Thales Papagiannakopoulos, Benjamin G. Neel, Nabeel Bardeesy, Kwok-kin Wong
Publikováno v:
bioRxiv
LKB1/STK11 is a serine/threonine kinase that plays a major role in controlling cell metabolism, resulting in potential therapeutic vulnerabilities in LKB1-mutant cancers. Here, we identify the NAD+degrading ectoenzyme, CD38, as a new target in LKB1-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664879e61c343e2d903f560a28e6eb38
https://europepmc.org/articles/PMC10153147/
https://europepmc.org/articles/PMC10153147/
Autor:
Benjamin G. Neel, Alireza Khodadadi-Jamayran, Benjamin Haibe-Kains, Abhyudai Singh, Jason Moffat, Beatrix Ueberheide, Aristotelis Tsirigos, Jane A. Skok, Adriana Heguy, Peter Meyn, Sylvia Adams, Kwok-kin Wong, Jiehui Deng, Christos Sotiriou, David Venet, Kwan Ho Tang, Avantika Dhabaria, Allison M.L. Nixon, Kevin R. Brown, Arvind Singh Mer, Azin Sayad, Shaowen Jiang, Jayu Jen, Chewei Anderson Chang
Supplementary Figure from Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1d61f7488bdc949f6ca073d647a681
https://doi.org/10.1158/2159-8290.22541321
https://doi.org/10.1158/2159-8290.22541321
Autor:
Benjamin G. Neel, Alireza Khodadadi-Jamayran, Benjamin Haibe-Kains, Abhyudai Singh, Jason Moffat, Beatrix Ueberheide, Aristotelis Tsirigos, Jane A. Skok, Adriana Heguy, Peter Meyn, Sylvia Adams, Kwok-kin Wong, Jiehui Deng, Christos Sotiriou, David Venet, Kwan Ho Tang, Avantika Dhabaria, Allison M.L. Nixon, Kevin R. Brown, Arvind Singh Mer, Azin Sayad, Shaowen Jiang, Jayu Jen, Chewei Anderson Chang
Resistance to targeted therapies is an important clinical problem in HER2-positive (HER2+) breast cancer. “Drug-tolerant persisters” (DTP), a subpopulation of cancer cells that survive via reversible, nongenetic mechanisms, are implicated in resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d194ed501ee311f5f4087871350c4b
https://doi.org/10.1158/2159-8290.c.6549611
https://doi.org/10.1158/2159-8290.c.6549611