Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jieh-Yuan Liou"'
Autor:
Jieh-Yuan Liou, Lee-Wen Chen, Shie-Shan Wang, Pey-Jium Chang, Chien-Hui Hung, Ju-Bei Yen, Li-Yu Chen
Publikováno v:
Virus Research. 165:157-169
The ORF46 gene of Kaposi's sarcoma-associated herpesvirus (KSHV) encodes uracil DNA glycosylase, an enzyme involved in DNA repair. In this study, we show that the transcriptional start site of the ORF46 gene is located at nucleotide 69,425 of the vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb7838383103ead5f805cd33d7b10f8
https://doi.org/10.1016/j.virusres.2012.02.010
https://doi.org/10.1016/j.virusres.2012.02.010
Autor:
Yeong-Shiau Pu, Jieh-Yuan Liou, Shih-Yi Chao, Shinzao Toh, Tzyh-Chyuan Hour, Chi-Hsien Chou, Chi-Yu Lu, Yu-Ting Kao, Huei-Ting Hu, A-Mei Huang, Pin-Yi Lin
Publikováno v:
Biochemical Pharmacology. 82:35-42
Gemcitabine (2'-deoxy-2', 2'-difluorocytidine; Gem) is a nucleoside anti-metabolite and is commonly used for treating various human cancers including human bladder carcinoma. Gemcitabine not only functions as a suicide nucleoside analog but also inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5d6564a0d44293e49c70e2beade3df
https://doi.org/10.1016/j.bcp.2011.03.026
https://doi.org/10.1016/j.bcp.2011.03.026
Publikováno v:
Molecular Pharmacology. 63:105-110
Deoxycytidylate deaminase, catalyzing the conversion of dCMP to dUMP, is an important enzyme in the de novo synthesis of thymidine nucleotides. It also may be involved in the action, as well as the metabolism of anticancer agents. Recently, several L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c73118261e01d1e7c6ec1ffa917d30b
https://doi.org/10.1124/mol.63.1.105
https://doi.org/10.1124/mol.63.1.105
Publikováno v:
Journal of Biological Chemistry. 277:31593-31600
Anticancer and antivirald- and l-nucleoside analogs are phosphorylated stepwise in the cells to the pharmacologically active triphosphate metabolites. We recently reported that in the last step,l-deoxynucleoside analog diphosphates are phosphorylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b8849e7c51345b3053f7ae52b023c76
https://doi.org/10.1074/jbc.m205115200
https://doi.org/10.1074/jbc.m205115200
Publikováno v:
Journal of Biological Chemistry. 277:5453-5459
D-Nucleoside analogs, which are in the natural configuration, as well as the L-nucleoside analogs, are clinically relevant antiviral and anticancer agents. Metabolism of L-nucleoside analog diphosphates to the triphosphates, however, remains unexplor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d269d78c92d5feb304e298a2b71257b5
https://doi.org/10.1074/jbc.m109025200
https://doi.org/10.1074/jbc.m109025200
Autor:
Shih-Tung Liu, Pey-Jium Chang, Wen-Hung Wang, Chen-Chia Hung, Ya-Fang Chiu, Lee-Wen Chen, Chien-Hui Hung, Ying-Ju Lin, Wan-Ju Tsai, Jieh-Yuan Liou, Chia-Ling Hung
Autophagy is an intracellular degradation pathway that provides a host defense mechanism against intracellular pathogens. However, many viruses exploit this mechanism to promote their replication. This study shows that lytic induction of Epstein-Barr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f554121324392e3b2638f7f3040a0854
https://europepmc.org/articles/PMC4178756/
https://europepmc.org/articles/PMC4178756/
Autor:
Hsu-Mei Hsu, Li-Ching Hsu, Yu-Chung Chang, Jin-Bau Fu, Kenneth S.S. Chang, Mei-Shang Ho, Kai-Ping N. Chow, Carlos Alberto Mandarim-de-Lacerda, Hong Chen, Francisco Borrego, Kang-Mai Wu, Chih-Feng Lu, Siu-Wah Chung, Cheng-Po Hu, Charles C. Y. Shih, John E. Coligan, Shwu-Fen Jiang, Wan-Jr Syu, Peter M. C. Wong, Rene Daniel, Leila Maria Meirelles Pereira, Ching-Gong Lin, Sung-Liang Yu, Shiang-Fen Huang, Hong-Sheng Kong, Jieh-Yuan Liou, Chungming Chang, Yi-Chien Mau, Ming F. Tam, Andrew G. Brooks, Phillip E. Posch, Guochuan Tsai, King-Song Jeng, Sheue-Rong Lin, June-Nam Seah, Hwia-Cheng Ding
Publikováno v:
Journal of Biomedical Science. 5:395-399
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e876238721eabd5866acf33d94adc6b
https://doi.org/10.1159/000025353
https://doi.org/10.1159/000025353
Autor:
Chien-Hui Hung, Bill Sugden, Jieh-Yuan Liou, Chih Ho Lai, Ya-Fang Chiu, Yu Ching Lan, Shih-Tung Liu, Pey-Jium Chang, Ying Ju Lin, Lee-Wen Chen
Epstein-Barr virus (EBV) BBLF1 shares 13 to 15% amino acid sequence identities with the herpes simplex virus 1 UL11 and cytomegalovirus UL99 tegument proteins, which are involved in the final envelopment during viral maturation. This study demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f366435a054c1041d01d1cbd044aecfb
https://europepmc.org/articles/PMC3446546/
https://europepmc.org/articles/PMC3446546/
Autor:
Wei-Ling Chang, Yung-Chi Cheng, Yu-Chun Huang, Mei-Ju Hsieh, Hui-Ru Lai, Chih-Hung Hsu, Jieh-Yuan Liou
Publikováno v:
Biochemical pharmacology. 79(3)
Deoxycytidine analogs are an important class of clinically active antiviral and anticancer agents. The stepwise phosphorylation of these analogs to triphosphate metabolites is crucial for biological action. Human UMP/CMP kinase (UMP/CMPK; cytidylate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b612e910c4cf3eb5faa0933d84adda37
https://pubmed.ncbi.nlm.nih.gov/19765547
https://pubmed.ncbi.nlm.nih.gov/19765547
Publikováno v:
Molecular pharmacology. 67(3)
Human UMP/CMP kinase (cytidylate kinase; EC 2.7.4.14) is responsible for phosphorylation of CMP, UMP, and deoxycytidine monophosphate (dCMP) and also plays an important role in the activation of pyrimidine analogs, some of which are clinically useful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4105cf581d74f98b4d2f97e90b5d3fa7
https://pubmed.ncbi.nlm.nih.gov/15550676
https://pubmed.ncbi.nlm.nih.gov/15550676