Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jiean Xu"'
Autor:
Yongfeng Cai, Yaqi Zhou, Qiuhua Yang, Jiean Xu, Qingen Da, Qian Ma, Dingwei Zhao, Tammy Lu, Ha Won Kim, David Fulton, Xuejun Jiang, Neal L. Weintraub, Kunzhe Dong, Suowen Xu, Mei Hong, Zhiping Liu, Yuqing Huo
Publikováno v:
Pharmacological Research, Vol 203, Iss , Pp 107156- (2024)
Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and morbidity and mortality rates continue to rise. Atherosclerosis constitutes the principal etiology of CVDs. Endothelial injury, inflammation, and dysfunction are the initiat
Externí odkaz:
https://doaj.org/article/bb67af2f38d24a85a9e9c90882d9873a
Autor:
Zhiping Liu, Huidong Shi, Jiean Xu, Qiuhua Yang, Qian Ma, Xiaoxiao Mao, Zhimin Xu, Yaqi Zhou, Qingen Da, Yongfeng Cai, David J.R. Fulton, Zheng Dong, Akrit Sodhi, Ruth B. Caldwell, Yuqing Huo
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
Pathological angiogenesis is a major cause of irreversible blindness in individuals of all age groups with proliferative retinopathy (PR). Mononuclear phagocytes (MPs) within neovascular areas contribute to aberrant retinal angiogenesis. Due to their
Externí odkaz:
https://doaj.org/article/d8faa0a88ffb4375acf7be6ca38fbe1b
Autor:
Jiean Xu, Lina Wang, Qiuhua Yang, Qian Ma, Yaqi Zhou, Yongfeng Cai, Xiaoxiao Mao, Qingen Da, Tammy Lu, Yunchao Su, Zsolt Bagi, Rudolf Lucas, Zhiping Liu, Mei Hong, Kunfu Ouyang, Yuqing Huo
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Sepsis, a pathology resulting from excessive inflammatory response that leads to multiple organ failure, is a major cause of mortality in intensive care units. Macrophages play an important role in the pathophysiology of sepsis. Accumulating evidence
Externí odkaz:
https://doaj.org/article/9347e206786c4b018ec1c48bc2cc7e1d
Autor:
Qiuhua Yang, Jiean Xu, Qian Ma, Zhiping Liu, Varadarajan Sudhahar, Yapeng Cao, Lina Wang, Xianqiu Zeng, Yaqi Zhou, Min Zhang, Yiming Xu, Yong Wang, Neal L. Weintraub, Chunxiang Zhang, Tohru Fukai, Chaodong Wu, Lei Huang, Zhen Han, Tao Wang, David J. Fulton, Mei Hong, Yuqing Huo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Increased glycolysis and inflammatory responses have been observed in endothelial cells exposed to disturbed flow. However, the role of endothelial glycolysis in atherosclerosis is unclear. Here the authors unveil a protective role for glycolysis by
Externí odkaz:
https://doaj.org/article/befd6b37207d47fb8d266efd4020896c
Autor:
Qiuhua Yang, Qian Ma, Jiean Xu, Zhiping Liu, Jianqiu Zou, Jian Shen, Yaqi Zhou, Qingen Da, Xiaoxiao Mao, Sarah Lu, David J. Fulton, Neal L. Weintraub, Zsolt Bagi, Mei Hong, Yuqing Huo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Myeloid cells, including monocytes/macrophages, primarily rely on glucose and lipid metabolism to provide the energy and metabolites needed for their functions and survival. AMP-activated protein kinase (AMPK, its gene is PRKA for human, Prka for rod
Externí odkaz:
https://doaj.org/article/4c62fe6b563b449385c46a47f4e5967a
Autor:
Yiming Xu, Yong Wang, Siyuan Yan, Yaqi Zhou, Qiuhua Yang, Yue Pan, Xianqiu Zeng, Xiaofei An, Zhiping Liu, Lina Wang, Jiean Xu, Yapeng Cao, David J Fulton, Neal L Weintraub, Zsolt Bagi, Md Nasrul Hoda, Xiaoling Wang, Qinkai Li, Mei Hong, Xuejun Jiang, Detlev Boison, Christian Weber, Chaodong Wu, Yuqing Huo
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 9, Pp 1263-1278 (2017)
Abstract The nucleoside adenosine is a potent regulator of vascular homeostasis, but it remains unclear how expression or function of the adenosine‐metabolizing enzyme adenosine kinase (ADK) and the intracellular adenosine levels influence angiogen
Externí odkaz:
https://doaj.org/article/76c3e705dd9743499adc42614850974d
Autor:
Weiqian Mai, Qingyou Liu, Jiasheng Li, Mincheng Zheng, Fuman Yan, Hui Liu, Yuhe Lei, Jinwen Xu, Jiean Xu
Publikováno v:
Aging. 15:3738-3758
Autor:
Qian Ma, Qiuhua Yang, Jiean Xu, Hunter G Sellers, Zach L Brown, Zhiping Liu, Zsuzsanna Bordan, Xiaofan Shi, Dingwei Zhao, Yongfeng Cai, Vidhi Pareek, Chunxiang Zhang, Guangyu Wu, Zheng Dong, Alexander D Verin, Lin Gan, Quansheng Du, Stephen J Benkovic, Suowen Xu, John M Asara, Issam Ben-Sahra, Scott Barman, Yunchao Su, David J R Fulton, Yuqing Huo
Publikováno v:
European Heart Journal. 44:1265-1279
Aims Proliferation of vascular smooth muscle cells (VSMCs) is a hallmark of pulmonary hypertension (PH). Proliferative cells utilize purine bases from the de novo purine synthesis (DNPS) pathways for nucleotide synthesis; however, it is unclear wheth
Autor:
Min, Zhang, Caiping, Wang, Rongning, Wang, Jiean, Xu, Zhefeng, Wang, Jianlong, Yan, Yongfeng, Cai, Liangping, Li, Yuqing, Huo, Shaohong, Dong
Publikováno v:
Journal of Molecular and Cellular Cardiology. 174:88-100
Pro-inflammatory and reparative macrophages are crucial in clearing necrotic myocardium and promoting cardiac repair after myocardial infarction (MI), respectively. Extracellular adenosine has been demonstrated to modulate macrophage polarization thr
Autor:
Qian Ma, Qiuhua Yang, Jiean Xu, Xiaoyu Zhang, David Kim, Zhiping Liu, Qingen Da, Xiaoxiao Mao, Yaqi Zhou, Yongfeng Cai, Vidhi Pareek, Ha Won Kim, Guangyu Wu, Zheng Dong, Wen-Liang Song, Lin Gan, Chunxiang Zhang, Mei Hong, Stephen J. Benkovic, Neal L. Weintraub, David Fulton, John M. Asara, Issam Ben-Sahra, Yuqing Huo
Publikováno v:
Circulation. 146:1444-1460
Background: Proliferation of vascular smooth muscle cells (VSMCs) is a hallmark of arterial diseases, especially in arterial restenosis after angioplasty or stent placement. VSMCs reprogram their metabolism to meet the increased requirements of lipid