Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Jie-quan Wang"'
1
Akademický článek
Role of NLRP3 in the pathogenesis and treatment of gout arthritis
Autor: Ya-ru Liu, Jie-quan Wang, Jun Li
Publikováno v: Frontiers in Immunology, Vol 14 (2023)
Gout arthritis (GA) is a common and curable type of inflammatory arthritis that has been attributed to a combination of genetic, environmental and metabolic factors. Chronic deposition of monosodium urate (MSU) crystals in articular and periarticular
Externí odkaz: https://doaj.org/article/7e41614a62b4430aaae455b931dae997
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3
Akademický článek
Ethenesulfonyl fluoride derivatives as telomerase inhibitors: structure-based design, SAR, and anticancer evaluation in vitro
Autor: Xing Chen, Gao-Feng Zha, Jie Quan Wang, Xin-Hua Liu
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1266-1270 (2018)
Based on our previous docking model, in order to carry out more rational drug design, totally 82 vinyl sulfonyl fluorides, including some 2-(hetero)arylethenesulfonyl fluorides and 1,3-dienylsulfonyl fluorides derivatives as potential human telomeras
Externí odkaz: https://doaj.org/article/8f96122fde9740d0b37fcab515e849a8
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4
Akademický článek
New pentadienone oxime ester derivatives: synthesis and anti-inflammatory activity
Autor: Qin Li, Juping Zhang, Liu Zeng Chen, Jie Quan Wang, Hai Ping Zhou, Wen Jian Tang, Wei Xue, Xin Hua Liu
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 130-138 (2018)
To develop novel anti-inflammatory agents, a series of new pentadienone oxime ester compounds were designed and synthesized. The structures were determined by IR, 1H NMR, 13 C NMR, and HRMS. All compounds have been screened for their anti-inflammator
Externí odkaz: https://doaj.org/article/e1612c3bbbe04301bcbdcb6f1c129351
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5
Akademický článek
Discovery of new chromen-4-one derivatives as telomerase inhibitors through regulating expression of dyskerin
Autor: Jie Quan Wang, Meng Di Yang, Xing Chen, Yang Wang, Liu Zeng Chen, Xiu Cheng, Xin Hua Liu
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1199-1211 (2018)
A series of new trimethoxyphenyl-4H-chromen derivatives as telomerase inhibitors through regulation dyskerin were designed and synthesised. The anticancer activity assay in vitro showed that compound 5i 3-(4-(4-isonicotinoylpiperazin-1-yl)butoxy)-5,7
Externí odkaz: https://doaj.org/article/38353f8152524ba291bbb1e51445926e
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6
Akademický článek
Emerging Roles for NLRC5 in Immune Diseases
Autor: Jie-quan Wang, Ya-ru Liu, Quan Xia, Ruo-nan Chen, Jun Liang, Qing-rong Xia, Jun Li
Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)
Innate immunity activates the corresponding immune response relying on multiple pattern recognition receptors (PRRs) that includes pattern recognition receptors (PRRs), like NOD-like receptors (NLRs), RIG-I-like receptors (RLRs), and C-type lectin re
Externí odkaz: https://doaj.org/article/af26c5c53e1d48239ef066aa64d251f7
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8
Novel curcumin analogue hybrids: Synthesis and anticancer activity
Autor: Jing Bo Shi, Xiaobin Wang, Wen Jian Tang, Yang Wang, Xin Hua Liu, Jie Quan Wang
Publikováno v: European Journal of Medicinal Chemistry. 156:493-509
In this study, twenty curcumin analogue hybrids as potential anticancer agents through regulation protein of TrxR were designed and synthesized. Results of anticancer activity showed that 5,7-dimethoxy-3-(3-(2-((1E, 4E)-3-oxo-5-(pyridin-2-yl)penta-1,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68383a50a69c2e1fa17ca97b38f5cb50
https://doi.org/10.1016/j.ejmech.2018.07.013
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9
Ethenesulfonyl fluoride derivatives as telomerase inhibitors: structure-based design, SAR, and anticancer evaluation in vitro
Autor: Jie Quan Wang, Xin-Hua Liu, Xing Chen, Gao-Feng Zha
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1266-1270 (2018)
Journal of Enzyme Inhibition and Medicinal Chemistry
Based on our previous docking model, in order to carry out more rational drug design, totally 82 vinyl sulfonyl fluorides, including some 2-(hetero)arylethenesulfonyl fluorides and 1,3-dienylsulfonyl fluorides derivatives as potential human telomeras
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3608b506c40ab8122c159b93a1296f5a
https://doi.org/10.1080/14756366.2018.1484735
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10
New arylpyrazoline-coumarins: Synthesis and anti-inflammatory activity
Autor: Jie Quan Wang, Jing Bo Shi, Wen Jian Tang, Wei Wei Sun, Liu Zeng Chen, Li Bo, Xin Hua Liu, Hai Pin Zhou, Cheng Xiu
Publikováno v: European Journal of Medicinal Chemistry. 138:170-181
To develop new anti-inflammatory agents with improved pharmaceutical profiles, a series of new phenyl-pyrazoline-coumarin derivatives (4a∼4m) were designed and synthesized. Compounds 4a and 4b were determined by X-ray crystallography. All of the co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ceba4ae5d7cc435944e6bb8a10d7bc
https://doi.org/10.1016/j.ejmech.2017.06.044
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