Výsledky vyhledávání - "Jie-Ping Geng"

Properties of a Recombinant Chimeric Protein in which the gamma-Carboxyglutamic Acid and Helical Stack Domains of Human Anticoagulant Protein C Are Replaced by those of Human Coagulation Factor VII

Autor: Francis J. Castellino, Jie-Ping Geng

Publikováno v: Thrombosis and Haemostasis. 77:0926-0933

SummaryA chimeric cDNA, encoding residues 1-46 (the γ-carboxyglutamic acid module and its trailing helical stack) of human coagulant factor (f) VII, bound to residues 47-419 of human anticoagulant protein C (PC), was constructed and expressed. The r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d0dc397792f8361fd2599931ad7bc71
https://doi.org/10.1055/s-0038-1656079

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Characterization of a cDNA Encoding Murine Coagulation Factor VII

Autor: Esohe Idusogie, Peter Carmeliet, Jie Ping Geng, Desire Collen, Elliot D. Rosen, Francis J. Castellino

Publikováno v: Thrombosis and Haemostasis. 75:481-487

SummaryThe cDNA encoding murine coagulation factor VII (mfVII) was isolated and reconstructed from a Λ Zap cDNA library generated from murine liver mRNA. The cDNA contains 1903 nucleotides spanning 15 bases upstream of the 5’-translation initiatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d26d91bc41bc5edc838ee9af2cfef76d
https://doi.org/10.1055/s-0038-1650301

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Functional Consequences of Mutations in Amino Acid Residues that Stabilize Calcium Binding to the First Epidermal Growth Factor Homology Domain of Human Protein C

Autor: Chong Hui Cheng, Jie Ping Geng, Francis J. Castellino

Publikováno v: Thrombosis and Haemostasis. 76:720-728

SummaryCharge-to-alanine mutations of three amino acid residues, viz., D46, D48, and D/Hya71, which are known to be important in stabilizing Ca2+ binding to epidermal growth factor (EGF) domains of vitamin K-de-pendent blood coagulation proteins, hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13063bca04033f44175891e41cd499ed
https://doi.org/10.1055/s-0038-1650650

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Transfer of specific endothelial cell-binding properties from the procoagulant protein human factor IX into the anticoagulant protein human protein C

Autor: Francis J. Castellino, Jie Ping Geng, William T. Christiansen, Edward F Plow

Publikováno v: Biochemistry. 34:8449-8457

A series of recombinant (r) chimeric mutants of human coagulation protein C (PC) and activated protein C (APC) containing replacements of homologous PC domains by those of human coagulation factor IX (fIX) were generated, with the intention of determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd1e0b2ac849cab951a98b4f5721684
https://doi.org/10.1021/bi00026a028

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Structure-function assessment of the role of the helical stack domain in the properties of human recombinant protein C and activated protein C

Autor: Jie-Ping Geng, Francis J. Castellino, William T. Christiansen

Publikováno v: Biochemistry. 34:8082-8090

The role of the helical stack (HS) in defining the properties of human recombinant (r) protein C (PC) and activated protein C (APC) was assessed. To do so, several mutations were made in this region of the molecule and their effects on the proteins e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa05702527d0ef46cb4527bfaa41ae3
https://doi.org/10.1021/bi00025a014

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Breakpoint clusters of thePML gene in acute promyelocytic leukemia: Primary structure of the reciprocal products of thePML-RARA gene in a patient with t(15;17)

Autor: Jia-Hua Tong, S. Dong, Zhen-Yi Wang, Jin-Ren Cai, Christian-Jacques Larsen, Yu Wu, Shu-Rong Chen, Zhu Chen, Guan-Lin Sun, Roland Berger, Sai-Juan Chen, Jie-Ping Geng

Publikováno v: Genes, Chromosomes and Cancer. 6:133-139

DNA studies of the translocation t(15;17) in acute promyelocytic leukemia (APL) have shown that the retinoic acid receptor alpha (RARA) gene on chromosome 17 is juxtaposed to the promyelocytic leukemia (PML) gene on chromosome 15. The PML breakpoints

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907dcb8d20518701f2bea57ed4da740d
https://doi.org/10.1002/gcc.2870060302

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The Propeptides of Human Protein C, Factor VII, and Factor IX Are Exchangeable with Regard to Directing Gamma-Carboxylation of these Proteins

Autor: Jie-Ping Geng, Francis J. Castellino

Publikováno v: Thrombosis and Haemostasis. 76:205-207

SummaryThe specificity of the propeptide sequence in directing vitamin Independent post-translational γ-carboxylation has been assessed by examination of the extent of processing of chimeric constructs of blood coagulation factor VII (fVII), factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8682e4e9565f4818007ae21b98d38b8d
https://doi.org/10.1055/s-0038-1650555

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The functions of the first epidermal growth factor homology region of human protein C as revealed by a charge-to-alanine scanning mutagenesis investigation

Autor: Jie Ping Geng, Chong Hui Cheng, Francis J. Castellino

Publikováno v: Biological chemistry. 378(12)

Variant proteins containing charge-to-alanine mutations of single amino acid residues and clusters of such groups contained in the epidermal growth factor 1 (EGF1) homology unit of human protein C (PC) have been accomplished, resulting in the followi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e1920a97ea4e99c6cdc42fb25ab77a
https://pubmed.ncbi.nlm.nih.gov/9461348

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The entire gamma-carboxyglutamic acid- and helical stack-domains of human coagulation factor IX are required for optimal binding to its endothelial cell receptor

Autor: Jie-Ping Geng, Francis J. Castellino, Scott E. Warder, Mary Prorok

Publikováno v: International journal of peptide and protein research. 48(3)

The minimal region of the gamma-carboxyglutamic acid (Gla) domain of human factor (f) IX that interacted with its putative bovine aortic endothelial cell (BAEC) receptor was examined by chemical synthesis of peptides with sequence counterparts in thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf23ef98bdddb04b71e43f06de2bb08
https://pubmed.ncbi.nlm.nih.gov/8897096

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