Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jie-Bin Ou"'
Publikováno v:
Molecules, Vol 28, Iss 14, p 5598 (2023)
MSN8C, an analog of mansonone E, has been identified as a novel catalytic inhibitor of human DNA topoisomerase II that induces tumor regression and differs from VP-16(etoposide). Treatment with MSN8C showed significant antiproliferative activity agai
Externí odkaz:
https://doaj.org/article/c0863f1cca36440f8b5b54c87cada5ed
Autor:
Pei-Fen Yao, Jie-Bin Ou, Du-Chao Zhou, Honggen Wang, Zhi-Shu Huang, Hua-Ting Xie, Cheng-Cheng Liang, Shi-Liang Huang, Shuo-Bin Chen, Yan-Wen Mai
Publikováno v:
Bioorganic chemistry. 114
Novel mansonone F derivative MSN54 (9-bromo-2,3-diethylbenzo[de]chromene-7,8-dione) exhibited significant cytotoxicity against twelve human tumor cell lines in vitro, with particularly strong potency against HL-60/MX2 cell line resistant to Topo II p
Autor:
Shuo-Bin Chen, Jie-Bin Ou, Jia-Heng Tan, Ding Li, Zhi-Shu Huang, Tian-Miao Ou, Liu-Lan Shen, Lian-Quan Gu, Shi-Liang Huang, Zhi-Hong Huang, Wei-Bin Wu
Publikováno v:
European Journal of Medicinal Chemistry. 46:3339-3347
A series of mansonone F (MF) derivatives were designed and synthesized. These compounds were found to be strong inhibitors for topoisomerases, with much more significant inhibition for topoisomerase II rather than topoisomerase I. The best inhibitor