Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jickky Palmae, Sarathy"'
Autor:
Pooja Gopal, Jickky Palmae Sarathy, Michelle Yee, Priya Ragunathan, Joon Shin, Shashi Bhushan, Junhao Zhu, Tatos Akopian, Olga Kandror, Teck Kwang Lim, Martin Gengenbacher, Qingsong Lin, Eric J. Rubin, Gerhard Grüber, Thomas Dick
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
It has been shown that the bioactive component of pyrazinamide, pyrazinoic acid (POA), blocks coenzyme A biosynthesis in M. tuberculosis by binding to the aspartate decarboxylase PanD. Here the authors show that pyrazinamide triggers degradation of P
Externí odkaz:
https://doaj.org/article/840f3d486eeb4f43af457982724b4b9d
Publikováno v:
Expert Opinion on Drug Discovery. 18:363-370
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b408b1a5999a0e960e4453def1a08229
https://doi.org/10.1080/17460441.2023.2178413
https://doi.org/10.1080/17460441.2023.2178413
Autor:
Jickky Palmae Sarathy, Matthew D. Zimmerman, Martin Gengenbacher, Véronique Dartois, Thomas Dick
Publikováno v:
Antimicrobial agents and chemotherapy. 66(12)
The anti-tuberculosis candidate OPC-167832, an inhibitor of DprE1, was active against Mycobacterium abscessus. Resistance mapped to M. abscessus dprE1, suggesting target retention. OPC-167832 was bactericidal and did not antagonize activity of clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecac7458e367897b6124c559db4800c
https://pubmed.ncbi.nlm.nih.gov/36350151
https://pubmed.ncbi.nlm.nih.gov/36350151
Autor:
Kevin Timothy, Fridianto, Gregory Adrian, Gunawan, Kiel, Hards, Jickky Palmae, Sarathy, Gregory M, Cook, Thomas, Dick, Mei-Lin, Go, Yulin, Lam
Publikováno v:
RSC medicinal chemistry. 13(12)
Due to its central role in energy generation and bacterial viability, mycobacterial bioenergetics is an attractive therapeutic target for anti-tuberculosis drug discovery. Building upon our work on antimycobacterial dioxonaphthoimidazoliums that were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc0a601c84487642065746f261a807f3
https://pubmed.ncbi.nlm.nih.gov/36545436
https://pubmed.ncbi.nlm.nih.gov/36545436
Autor:
Patcharaporn Sae-Lao, Wuan Geok Saw, Chaudhari Namrata Pradeep, Anders Poulsen, Jocelyn Hui Ling Tan, Jickky Palmae Sarathy, Pearly Shuyi Ng, Gerhard Grüber, Peter Dröge, Revathy Kalyanasundaram, Pattarakiat Seankongsuk, Priya Ragunathan, Sivaraj Anbarasu, Umayal Lakshmanan, Harshyaa Makhija, Roderick W. Bates, Kevin Pethe, Krupakar Parthasarathy, Thomas Dick, Amaravadhi Harikishore, Adam Hotra, Joon Shin, Nitin Pal Kalia
Publikováno v:
Angewandte Chemie. 132:13397-13406
The F1 FO -ATP synthase is required for growth and viability of Mycobacterium tuberculosis and is a validated clinical target. A mycobacterium-specific loop of the enzyme's rotary γ subunit plays a role in the coupling of ATP synthesis within the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ffd8a157e15476795321ceca37daa1
https://doi.org/10.1002/ange.202002546
https://doi.org/10.1002/ange.202002546
Autor:
Gerhard Grüber, Roderick W. Bates, Thomas Dick, Liam K. Harold, Jickky Palmae Sarathy, Malathy Sony Subramanian Manimekalai, Shi Min Sherilyn Chong, Gregory M. Cook, Zoe C. Williams, Kevin Pethe
Publikováno v:
ACS Infectious Diseases. 6:725-737
The ability to respire and generate adenosine triphosphate (ATP) is essential for the physiology, persistence, and pathogenicity of Mycobacterium tuberculosis, which causes tuberculosis. By employing a lead repurposing strategy, the malarial cytochro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e36cfcb770a0514e35648c28def660f
https://doi.org/10.1021/acsinfecdis.9b00408
https://doi.org/10.1021/acsinfecdis.9b00408
Autor:
Kevin Timothy Fridianto, Gregory Adrian Gunawan, Kiel Hards, Jickky Palmae Sarathy, Gregory M. Cook, Thomas Dick, Mei-Lin Go, Yulin Lam
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e0426625cea69551652718dccc4ec44
https://doi.org/10.2139/ssrn.4085430
https://doi.org/10.2139/ssrn.4085430
Autor:
Véronique Dartois, Jickky Palmae Sarathy, Matthew D. Zimmerman, Uday S. Ganapathy, Thomas Dick, Martin Gengenbacher
Publikováno v:
Antimicrobial Agents and Chemotherapy
Lung disease caused by Mycobacterium abscessus is very difficult to cure, and treatment failure rates are high. The antituberculosis drug bedaquiline (BDQ) is used as salvage therapy against this dreadful disease. However, BDQ is highly lipophilic, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1338fc2b259967529354baa927444d
https://doi.org/10.1128/aac.02404-19
https://doi.org/10.1128/aac.02404-19
Autor:
Shi Min Sherilyn, Chong, Malathy Sony Subramanian, Manimekalai, Jickky Palmae, Sarathy, Zoe C, Williams, Liam K, Harold, Gregory M, Cook, Thomas, Dick, Kevin, Pethe, Roderick W, Bates, Gerhard, Grüber
Publikováno v:
ACS infectious diseases. 6(4)
The ability to respire and generate adenosine triphosphate (ATP) is essential for the physiology, persistence, and pathogenicity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13393ca5d33a49d59e87050af227046d
https://pubmed.ncbi.nlm.nih.gov/32092260
https://pubmed.ncbi.nlm.nih.gov/32092260
Autor:
Gerhard Grüber, Jickky Palmae Sarathy, Priya Ragunathan, Christopher B. Cooper, Anna M. Upton, Thomas Dick
Publikováno v:
Antimicrobial Agents and Chemotherapy
The diarylquinoline F1FO-ATP synthase inhibitor bedaquiline (BDQ) displays protonophore activity. Thus, uncoupling electron transport from ATP synthesis appears to be a second mechanism of action of this antimycobacterial drug. Here, we show that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596c3c068c7673da022cf7d0417a88d4
https://doi.org/10.1128/aac.01540-19
https://doi.org/10.1128/aac.01540-19