Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jibu Lu"'
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Triple-negative breast cancer (TNBC) is the subtype with the worst prognosis of breast cancer. Ferroptosis, a novel iron-dependent programmed cell death, has an increasingly important role in tumorigenesis and development. However, there is still a l
Externí odkaz:
https://doaj.org/article/661be593c2be4ebb8b4eb961a1a285d4
Autor:
Jibu Lu, Yongjun Huang, Jing Huang, Rui He, Minhao Huang, Xiaoyun Lu, Yong Xu, Fengtao Zhou, Zhang Zhang, Ke Ding
Publikováno v:
Journal of Medicinal Chemistry. 65:2313-2328
The first examples of threonine tyrosine kinase (TTK) PROTACs were designed and synthesized. Two of the most potent molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea1215ad315f59529f85ec1249b81aa
https://doi.org/10.1021/acs.jmedchem.1c01768
https://doi.org/10.1021/acs.jmedchem.1c01768
Background Among patients with triple-negative breast cancer (TNBC), distant metastasis is the leading cause of death. Our previous studies have shown that TNBC progression is greatly facilitated by circKIF4A, but uncertainty remains regarding the ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35ff7eb254ad0d81dd497236ad614999
https://doi.org/10.21203/rs.3.rs-2039880/v1
https://doi.org/10.21203/rs.3.rs-2039880/v1
Autor:
Junhua, Li, Cheng, Zhang, Hongrui, Xu, Chao, Wang, Ruibo, Dong, Hui, Shen, Xiaoxi, Zhuang, Xiaoshan, Chen, Qiu, Li, Jibu, Lu, Maofeng, Zhang, Xishan, Wu, Kerry M, Loomes, Yulai, Zhou, Yan, Zhang, Jinsong, Liu, Yong, Xu
Publikováno v:
Journal of medicinal chemistry. 65(7)
Pan-bromodomain and extra terminal (Pan-BET) inhibitors show profound efficacy but exhibit pharmacology-driven toxicities in clinical trials. The development of domain-selective BET inhibitors to separate efficacy and toxicity is urgently needed. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c813ed8ddc6dd691726b7e1d3fad0ba
https://pubmed.ncbi.nlm.nih.gov/35333526
https://pubmed.ncbi.nlm.nih.gov/35333526
Autor:
Ke Ding, Jibu Lu, Lianwen Zhang, Xiaomei Ren, Huimin Cheng, Zhengchao Tu, Jinfeng Luo, Yu Chang, Qingwen Zhang, Xiaoyun Lu
Publikováno v:
Journal of medicinal chemistry. 57(6)
Epidermal growth factor receptor (EGFR) amplification has been demonstrated to be critical for the inherent and/or acquired resistance against current B-Raf(V600E) inhibitor therapy for melanoma and colorectal cancer patients. We describe the discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60c222f110256e47bf0f2bcee8b689a
https://pubmed.ncbi.nlm.nih.gov/24588073
https://pubmed.ncbi.nlm.nih.gov/24588073