Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jibrin A. Kama"'
Autor:
Jonathan H Fox, Jibrin A Kama, Gregory Lieberman, Raman Chopra, Kate Dorsey, Vanita Chopra, Irene Volitakis, Robert A Cherny, Ashley I Bush, Steven Hersch
Publikováno v:
PLoS ONE, Vol 2, Iss 3, p e334 (2007)
Huntington's disease (HD) is caused by a dominant polyglutamine expansion within the N-terminus of huntingtin protein and results in oxidative stress, energetic insufficiency and striatal degeneration. Copper and iron are increased in the striata of
Externí odkaz:
https://doaj.org/article/89ba0b8f672040a4a86f8059589f7a88
Autor:
Jibrin A. Kama, Anthone W. Dunah, Alexandre Kuhn, Doris C. V. Thu, David Taylor, Ruth Luthi-Carter, Birgit Zucker, Lianna R. Orlando, Ozgun Gokce, Johann Lambeck, Bernd Friedrich, Cornelius Weiller, Katrin S. Lindenberg, Richard L.M. Faull, Anne B. Young
Publikováno v:
Journal of Neuropathology and Experimental Neurology; Vol 69
Motor dysfunction, cognitive impairment, and regional cortical atrophy indicate cerebral cortical involvement in Huntington disease (HD). To address the hypothesis that abnormal corticostriatal connectivity arises from polyglutamine-related alteratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f96c5a7b9fada26bd3789cf876fc6f
https://doi.org/10.1097/nen.0b013e3181ed7a41
https://doi.org/10.1097/nen.0b013e3181ed7a41
Autor:
Raman Chopra, Vanita Chopra, Jibrin A. Kama, Robert A. Cherny, Jonathan H. Fox, Irene Volitakis, Ashley I. Bush, Kate Dorsey, Steven M. Hersch, Gregory Lieberman
Publikováno v:
PLoS ONE
PLoS ONE, Vol 2, Iss 3, p e334 (2007)
PLoS ONE, Vol 2, Iss 3, p e334 (2007)
Huntington's disease (HD) is caused by a dominant polyglutamine expansion within the N-terminus of huntingtin protein and results in oxidative stress, energetic insufficiency and striatal degeneration. Copper and iron are increased in the striata of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da20863cc2074ea462dd98e135bbb469
https://pubmed.ncbi.nlm.nih.gov/17396163
https://pubmed.ncbi.nlm.nih.gov/17396163
Autor:
David G. Standaert, Jibrin A. Kama, Birgit Zucker, Anthone W. Dunah, Jonathan H. Fox, Ruth Luthi-Carter, Sarah J. Augood, Anne B. Young, Edward A. Stern
Publikováno v:
Human molecular genetics. 14(2)
Transcriptional dysregulation has been described as a central mechanism in the pathogenesis of Huntington's disease (HD), in which medium spiny projection neurons (MSN) selectively degenerate whereas neuronal nitric-oxide-synthase-positive interneuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bc4f690f09d8e28fc74ed6dc75be7c
https://pubmed.ncbi.nlm.nih.gov/15548548
https://pubmed.ncbi.nlm.nih.gov/15548548
Autor:
Daniel Hoyer, Stefan Frentzel, Marian DiFiglia, Dorothee Bleckmann, Teal Connor, Jibrin A. Kama, Vanita Chopra, Claudia Betschart, Kate Dorsey, Paolo Paganetti, Steven M. Hersch, Jonathan H. Fox
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 5, Iss 1, p 26 (2010)
Molecular Neurodegeneration, Vol 5, Iss 1, p 26 (2010)
Background Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion within the huntingtin gene. Mutant huntingtin protein misfolds and accumulates within neurons where it mediates its toxic effects. Promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f64a522c1da890f8c0a7e1c0abce021