Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jibrin A. Kama"'
Autor:
Jonathan H Fox, Jibrin A Kama, Gregory Lieberman, Raman Chopra, Kate Dorsey, Vanita Chopra, Irene Volitakis, Robert A Cherny, Ashley I Bush, Steven Hersch
Publikováno v:
PLoS ONE, Vol 2, Iss 3, p e334 (2007)
Huntington's disease (HD) is caused by a dominant polyglutamine expansion within the N-terminus of huntingtin protein and results in oxidative stress, energetic insufficiency and striatal degeneration. Copper and iron are increased in the striata of
Externí odkaz:
https://doaj.org/article/89ba0b8f672040a4a86f8059589f7a88
Autor:
Jibrin A. Kama, Anthone W. Dunah, Alexandre Kuhn, Doris C. V. Thu, David Taylor, Ruth Luthi-Carter, Birgit Zucker, Lianna R. Orlando, Ozgun Gokce, Johann Lambeck, Bernd Friedrich, Cornelius Weiller, Katrin S. Lindenberg, Richard L.M. Faull, Anne B. Young
Publikováno v:
Journal of Neuropathology and Experimental Neurology; Vol 69
Motor dysfunction, cognitive impairment, and regional cortical atrophy indicate cerebral cortical involvement in Huntington disease (HD). To address the hypothesis that abnormal corticostriatal connectivity arises from polyglutamine-related alteratio
Autor:
Raman Chopra, Vanita Chopra, Jibrin A. Kama, Robert A. Cherny, Jonathan H. Fox, Irene Volitakis, Ashley I. Bush, Kate Dorsey, Steven M. Hersch, Gregory Lieberman
Publikováno v:
PLoS ONE
PLoS ONE, Vol 2, Iss 3, p e334 (2007)
PLoS ONE, Vol 2, Iss 3, p e334 (2007)
Huntington's disease (HD) is caused by a dominant polyglutamine expansion within the N-terminus of huntingtin protein and results in oxidative stress, energetic insufficiency and striatal degeneration. Copper and iron are increased in the striata of
Autor:
David G. Standaert, Jibrin A. Kama, Birgit Zucker, Anthone W. Dunah, Jonathan H. Fox, Ruth Luthi-Carter, Sarah J. Augood, Anne B. Young, Edward A. Stern
Publikováno v:
Human molecular genetics. 14(2)
Transcriptional dysregulation has been described as a central mechanism in the pathogenesis of Huntington's disease (HD), in which medium spiny projection neurons (MSN) selectively degenerate whereas neuronal nitric-oxide-synthase-positive interneuro
Autor:
Daniel Hoyer, Stefan Frentzel, Marian DiFiglia, Dorothee Bleckmann, Teal Connor, Jibrin A. Kama, Vanita Chopra, Claudia Betschart, Kate Dorsey, Paolo Paganetti, Steven M. Hersch, Jonathan H. Fox
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 5, Iss 1, p 26 (2010)
Molecular Neurodegeneration, Vol 5, Iss 1, p 26 (2010)
Background Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion within the huntingtin gene. Mutant huntingtin protein misfolds and accumulates within neurons where it mediates its toxic effects. Promo
Autor:
Zucker, Birgit, Kama, Jibrin A., Kuhn, Alexandre, Thu, Doris, Orlando, Lianna R., Dunah, Anthone W., Gokce, Ozgun, Taylor, David M., Lambeck, Johann, Friedrich, Bernd, Lindenberg, Katrin S., Faull, Richard L.M., Weiller, Cornelius, Young, Anne B., Luthi-Carter, Ruth
Publikováno v:
Journal of Neuropathology & Experimental Neurology; Sep2010, Vol. 69 Issue 9, p880-895, 16p
Autor:
Zucker, Birgit, Luthi-Carter, Ruth, Kama, Jibrin A., Dunah, Anthone W., Stern, Edward A., Fox, Jonathan H., Standaert, David G., Young, Anne B., Augood, Sarah J.
Publikováno v:
Human Molecular Genetics; Jan2005, Vol. 14 Issue 2, p179-189, 11p, 2 Color Photographs, 1 Diagram, 2 Charts, 2 Graphs