Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jiazhen Guan"'
Autor:
Shaun M. Pienkos, Andrew R. Moore, Jiazhen Guan, Joseph E. Levitt, Michael A. Matthay, Rebecca M. Baron, John Conlon, Daniel F. McAuley, Cecilia M. O’Kane, Angela J. Rogers
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-9 (2023)
Abstract Background Two acute respiratory distress syndrome (ARDS) trials showed no benefit for statin therapy, though secondary analyses suggest inflammatory subphenotypes may have a differential response to simvastatin. Statin medications decrease
Externí odkaz:
https://doaj.org/article/65d6714ebc4c4cc289e1fce88f12a77f
Autor:
Nunzia Caporarello, Jisu Lee, Tho X. Pham, Dakota L. Jones, Jiazhen Guan, Patrick A. Link, Jeffrey A. Meridew, Grace Marden, Takashi Yamashita, Collin A. Osborne, Aditya V. Bhagwate, Steven K. Huang, Roberto F. Nicosia, Daniel J. Tschumperlin, Maria Trojanowska, Giovanni Ligresti
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Vascular dysfunction is associated with ageing and chronic diseases, but its role in lung repair and fibrosis is unclear. Here, the authors show that the endothelial transcription factor ERG is a mediator of vascular repair whose function declines in
Externí odkaz:
https://doaj.org/article/daafa3bab0f84e5aac96c4fd16989387
Autor:
Tho X. Pham, Jisu Lee, Jiazhen Guan, Nunzia Caporarello, Jeffrey A. Meridew, Dakota L. Jones, Qi Tan, Steven K. Huang, Daniel J. Tschumperlin, Giovanni Ligresti
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
Idiopathic pulmonary fibrosis (IPF) is an aging-associated disease characterized by myofibroblast accumulation and progressive lung scarring. To identify transcriptional gene programs driving persistent lung fibrosis in aging, we performed RNA-Seq on
Externí odkaz:
https://doaj.org/article/3a0a0523adac4695b22fc235f7882964
Autor:
Nunzia Caporarello, Jisu Lee, Tho X. Pham, Dakota L. Jones, Jiazhen Guan, Patrick A. Link, Jeffrey A. Meridew, Grace Marden, Takashi Yamashita, Collin A. Osborne, Aditya V. Bhagwate, Steven K. Huang, Roberto F. Nicosia, Daniel J. Tschumperlin, Maria Trojanowska, Giovanni Ligresti
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/bd2f31264b6c4ab8b5c50c045ac76d33
Autor:
Moore, Andrew R., Pienkos, Shaun M., Sinha, Pratik, Jiazhen Guan, O’Kane, Cecilia M., Levitt, Joseph E., Wilson, Jennifer G., Shankar-Hari, Manu, Matthay, Michael A., Calfee, Carolyn S., Baron, Rebecca M., McAuley, Daniel F., Rogers, Angela J.
Publikováno v:
Critical Care Medicine; Dec2023, Vol. 51 Issue 12, pe269-e274, 6p
Autor:
Andrew R Moore, Shaun M Pienkos, Pratik Sinha, Jiazhen Guan, Cecilia M O’Kane, Joseph E Levitt, Jennifer G Wilson, Manu Shankar-Hari, Michael A Matthay, Carolyn S Calfee, Rebecca M Baron, Daniel F McAuley, Angela J Rogers
Background: Both latent class analysis (LCA) assignment based upon a panel of plasma biomarkers and interleukin-18 (IL-18) plasma level have been shown to predict prognosis and treatment response in Acute Respiratory Distress Syndrome (ARDS). Interle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23d5cf17d583b193692d196da3fb4e87
https://doi.org/10.21203/rs.3.rs-2256911/v1
https://doi.org/10.21203/rs.3.rs-2256911/v1
Autor:
Nunzia, Caporarello, Jisu, Lee, Tho X, Pham, Dakota L, Jones, Jiazhen, Guan, Patrick A, Link, Jeffrey A, Meridew, Grace, Marden, Takashi, Yamashita, Collin A, Osborne, Aditya V, Bhagwate, Steven K, Huang, Roberto F, Nicosia, Daniel J, Tschumperlin, Maria, Trojanowska, Giovanni, Ligresti
Publikováno v:
Nature communications. 13(1)
Vascular dysfunction is a hallmark of chronic diseases in elderly. The contribution of the vasculature to lung repair and fibrosis is not fully understood. Here, we performed an epigenetic and transcriptional analysis of lung endothelial cells (ECs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4cdaa2abbc55ace08d2a585ae38b8cc0
https://pubmed.ncbi.nlm.nih.gov/36171208
https://pubmed.ncbi.nlm.nih.gov/36171208
Autor:
Rebecca M. Baron, Augustine M.K. Choi, Rajani Kaimal, Art Wheeler, Joo Heon Yoon, Anna Trtchounian, Jay S. Steingrub, Lesley Desouza, Jiazhen Guan, Gary M. Hunninghake, Michael A. Matthay, Susan Mogan, Angela J. Rogers, Kiichi Nakahira, Lori Ann Kozikowski, Manisha Desai, Kathleen D. Liu
Publikováno v:
Critical care medicine, vol 47, iss 8
ObjectiveA high plasma level of inflammasome mediator interleukin-18 was associated with mortality in observational acute respiratory distress syndrome cohorts. Statin exposure increases both inflammasome activation and lung injury in mouse models. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f16f63d414fffb25e2b40a1ddb2827e
https://escholarship.org/uc/item/9bw1q0qq
https://escholarship.org/uc/item/9bw1q0qq
Autor:
Awapuhi K Lee, Rebecca M. Baron, Alvaro Macias, Gregory Crosby, Diana Amador-Munoz, Joshua A. Englert, Colleen Isabelle, Margarita M. Suarez Velandia, Deborah J. Culley, Brady Magaoay, Laura E. Fredenburgh, Anna Coronata, Jiazhen Guan, Miguel Pinilla Vera
Publikováno v:
Anesthesiology. 123:377-388
Background: Isoflurane may be protective in preclinical models of lung injury, but its use in patients with lung injury remains controversial and the mechanism of its protective effects remains unclear. The authors hypothesized that this protection i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec055a27025a7a29fcc91c816b96a9e
https://doi.org/10.1097/aln.0000000000000742
https://doi.org/10.1097/aln.0000000000000742
Autor:
Jiazhen Guan, Miguel Pinilla-Vera, Alvin T. Kho, Francis Boudreault, Joshua A. Englert, Daniel J. Tschumperlin, Kyoung Moo Choi, Carolina Quintana, Micu Registry, Antonio J. Arciniegas, Colleen Isabelle, Rebecca M. Baron, Shelley Hurwitz, Lynette M. Sholl, Diana Amador-Munoz, Diana Barragan-Bradford
Mechanical ventilation is necessary to support patients with acute lung injury, but also exacerbates injury through mechanical stress-activated signaling pathways. We show that stretch applied to cultured human cells, and to mouse lungs in vivo, indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30afa170512ce5091ec63a9260a8ea8f
https://europepmc.org/articles/PMC5453708/
https://europepmc.org/articles/PMC5453708/