Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Jiazhang Qiu"'
Autor:
Jinli Ge, Ying Wang, Xueyu Li, Qian Lu, Hangqian Yu, Hongtao Liu, Kelong Ma, Xuming Deng, Zhao-Qing Luo, Xiaoyun Liu, Jiazhang Qiu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The intracellular bacterial pathogen Legionella pneumophila utilizes the Dot/Icm system to translocate over 330 effectors into the host cytosol. These virulence factors modify a variety of cell processes, including pathways involved in cell
Externí odkaz:
https://doaj.org/article/e80fcb2ff5c44010bb07b54f56e70395
Autor:
Hongtao Liu, Siqi Li, Le Deng, Zhenxu Shi, Chenxiao Jiang, Jingyan Shu, Yuan Liu, Xuming Deng, Jianfeng Wang, Zhimin Guo, Jiazhang Qiu
Publikováno v:
Engineering, Vol 39, Iss , Pp 180-193 (2024)
Infections caused by intracellular bacterial pathogens are difficult to treat since most antibiotics have low cell permeability and undergo rapid degradation within cells. The rapid development and dissemination of antimicrobial–resistant strains h
Externí odkaz:
https://doaj.org/article/94abbaaf59e5416ea96fd8e5c5a2e8f1
Autor:
Yunfei Wei, Meiyu Jin, Hao Yu, Xiaoning Hou, Lilei Zhao, Lu Ding, Jiaqi Cheng, Jiazhang Qiu, Haihua Feng
Publikováno v:
Journal of Functional Foods, Vol 116, Iss , Pp 106143- (2024)
Glycyrrhiza glabra L. is a common heritage herbal medicine rich in antioxidant compounds such as flavonoids and triterpenoids. Non-alcoholic fatty liver disease has been the global prevalent chronic liver disorder. To investigate the curative role an
Externí odkaz:
https://doaj.org/article/1d1b0ade37aa44fd8d7f92253b0d25ee
Publikováno v:
Shipin gongye ke-ji, Vol 44, Iss 15, Pp 62-68 (2023)
To explore the inhibitory effect of myristic acid against suilysin biological activity and the interactive mechanism, pore-forming assay, oligomerization assay, molecular docking, molecular dynamics simulation, minimal inhibitory concentration assay
Externí odkaz:
https://doaj.org/article/0bdab864079040ae9627089620d87ccf
Autor:
Qinxin Zhang, Wei Xian, Zilin Li, Qian Lu, Xindi Chen, Jinli Ge, Zhiheng Tang, Bohao Liu, Zhe Chen, Xiang Gao, Michael O. Hottiger, Peipei Zhang, Jiazhang Qiu, Feng Shao, Xiaoyun Liu
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113789- (2024)
Summary: Under stress conditions, translationally stalled mRNA and associated proteins undergo liquid-liquid phase separation and condense into cytoplasmic foci called stress granules (SGs). Many viruses hijack SGs for their pathogenesis; however, wh
Externí odkaz:
https://doaj.org/article/c3af4c7c6eab463280275fc7431f05f6
Autor:
Siqi Li, Hongtao Liu, Jingyan Shu, Quanshun Li, Yuan Liu, Haihua Feng, Jianfeng Wang, Xuming Deng, Yong Zhang, Zhimin Guo, Jiazhang Qiu
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT Salmonella enterica is an important zoonotic intracellular bacterial pathogen that is capable of causing infections ranging from localized gastroenteritis to fatal systemic infection in humans and food-producing animals. The increasing antib
Externí odkaz:
https://doaj.org/article/acd6c5d9a5614ab2bf1df8e697fb9199
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTLegionella pneumophila is a facultative intracellular pathogen that causes legionellosis. The key to its virulence is the delivery of hundreds of effector proteins into host cells via the defective in organelle trafficking/intracellular multi
Externí odkaz:
https://doaj.org/article/5e19dbd6bf4843b5a222fb297e72b58a
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112817- (2023)
Summary: Xenophagy is an evolutionarily conserved host defensive mechanism to eliminate invading microorganisms through autophagic machinery. The intracellular bacterial pathogen Legionella pneumophila can avoid clearance by the xenophagy pathway via
Externí odkaz:
https://doaj.org/article/29ebcf987cb343dfa9dca624769a7b5c
Autor:
Xiangkai Zhen, Yongyu Wu, Jinli Ge, Jiaqi Fu, Le Ye, Niannian Lin, Zhijie Huang, Zihe Liu, Zhao-qing Luo, Jiazhang Qiu, Songying Ouyang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Here, the authors demonstrate that the Legionella pneumophila T4SS effector protein Lpg2370 is a Ser/Thr kinase and a toxin of a tripartite HipBST toxin-antitoxin (TA) system. Structural data and biochemical analysis provide detailed insights into th
Externí odkaz:
https://doaj.org/article/1487df0573c54c1a849daa2b17a70483
Autor:
Yumeng Song, Pei Huang, Mengtao Yu, Yuanguo Li, Hongli Jin, Jiazhang Qiu, Yuanyuan Li, Yuwei Gao, Haili Zhang, Hualei Wang
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was initially identified in 2019, after which it spread rapidly throughout the world. With the progression of the epidemic,
Externí odkaz:
https://doaj.org/article/2ee3cc6a351e4be48edb53faec634c17