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Akademický článek

PQR309, a dual PI3K/mTOR inhibitor, synergizes with gemcitabine by impairing the GSK-3β and STAT3/HSP60 signaling pathways to treat nasopharyngeal carcinoma

Autor: Jiaxin Cao, Kangmei Zeng, Qun Chen, Ting Yang, Feiteng Lu, Chaozhuo Lin, Jianhua Zhan, Wenjuan Ma, Ting Zhou, Yan Huang, Fan Luo, Hongyun Zhao

Publikováno v: Cell Death and Disease, Vol 15, Iss 3, Pp 1-15 (2024)

Abstract End-stage nasopharyngeal carcinoma (NPC) has unsatisfactory survival. The limited benefit of chemotherapy and the scarcity of targeted drugs are major challenges in NPC. New approaches to treat late-stage NPC are urgently required. In this s

Externí odkaz: https://doaj.org/article/199c969377334b599c78050b84ac1bbd

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Akademický článek

HDL-cholesterol confers sensitivity of immunotherapy in nasopharyngeal carcinoma via remodeling tumor-associated macrophages towards the M1 phenotype

Autor: Yan Huang, Li Zhang, Ting Yang, Hongyun Zhao, Yunpeng Yang, Ting Zhou, Jianhua Zhan, Xue Bai, Fan Luo, Qun Chen, Wenjuan Ma, Jiaxin Cao, Lusha Liu, Chaozhuo Lin

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 6 (2024)

Background The sustained effectiveness of anti-programmed cell death protein-1/programmed death-ligand 1 treatment is limited to a subgroup of patients with advanced nasopharyngeal carcinoma (NPC), and the specific biomarker determining the response

Externí odkaz: https://doaj.org/article/39bb20826f614805b273174ab547a331

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Akademický článek

Influence of TP53 mutation on efficacy and survival in advanced EGFR‐mutant non‐small cell lung cancer patients treated with third‐generation EGFR tyrosine kinase inhibitors

Autor: Zhonghan Zhang, Jinhui Xue, Yunpeng Yang, Wenfeng Fang, Yan Huang, Shen Zhao, Fan Luo, Jiaxin Cao, Kangmei Zeng, Wenjuan Ma, Jianhua Zhan, Feiteng Lu, Li Zhang, Hongyun Zhao

Publikováno v: MedComm, Vol 5, Iss 6, Pp n/a-n/a (2024)

Abstract TP53 comutation is related to poor prognosis of non‐small cell lung cancer. However, there is limited study focusing on the structural influence of TP53 mutation on third‐generation epidermal growth factor receptor tyrosine kinase inhibi

Externí odkaz: https://doaj.org/article/efaaf10675ae4c75be284d3463f942ca

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Akademický článek

Myocardial deformation characteristics assessed by cardiovascular magnetic resonance feature tracking in a healthy Chinese population

Autor: Huihui Kong, Jiaxin Cao, Lijun Zhang, Jing An, Xiaohua Wu, Yi He

Publikováno v: Heliyon, Vol 10, Iss 7, Pp e28341- (2024)

Purpose: To explore global/regional myocardial deformation across various layers, vascular distributions, specific levels and distinct walls in healthy individuals using cardiovascular magnetic resonance feature tracking (CMR-FT). Methods: We selecte

Externí odkaz: https://doaj.org/article/e0ea82ee9f854c129fc958290fdbf6a5

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Akademický článek

Predictive value of immunotherapy-induced inflammation indexes: dynamic changes in patients with nasopharyngeal carcinoma receiving immune checkpoint inhibitors

Autor: Jiaxin Cao, Qun Chen, Xue Bai, Lusha Liu, Wenjuan Ma, Chaozhuo Lin, Feiteng Lu, Ting Zhou, Jianhua Zhan, Yan Huang, Yunpeng Yang, Fan Luo, Hongyun Zhao

Publikováno v: Annals of Medicine, Vol 55, Iss 2 (2023)

AbstractBackground Immune checkpoint inhibitors (ICIs) have achieved substantial advancements in clinical care. However, there is no strong evidence for identified biomarkers of ICIs in NPC.Methods In this retrospective study, 284 patients were enrol

Externí odkaz: https://doaj.org/article/d64cb67eeade4e5d86e7032311ac1d89

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Akademický článek

Meteorological Impacts on Rubber Tree Powdery Mildew and Projections of Its Future Spatiotemporal Pattern

Autor: Jiayan Kong, Lan Wu, Jiaxin Cao, Wei Cui, Tangzhe Nie, Yinghe An, Zhongyi Sun

Publikováno v: Agriculture, Vol 14, Iss 4, p 619 (2024)

Meteorological conditions play a crucial role in driving outbreaks of rubber tree powdery mildew (RTPM). As the climate warms and techniques improve, rubber cultivation is expanding to higher latitudes, and the changing climate increases the RTPM ris

Externí odkaz: https://doaj.org/article/2ed5076caa914263b5c10ececfc7e0a5

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Akademický článek

Motion artefact reduction in coronary CT angiography images with a deep learning method

Autor: Pengling Ren, Yi He, Yi Zhu, Tingting Zhang, Jiaxin Cao, Zhenchang Wang, Zhenghan Yang

Publikováno v: BMC Medical Imaging, Vol 22, Iss 1, Pp 1-9 (2022)

Abstract Background The aim of this study was to investigate the ability of a pixel-to-pixel generative adversarial network (GAN) to remove motion artefacts in coronary CT angiography (CCTA) images. Methods Ninety-seven patients who underwent single-

Externí odkaz: https://doaj.org/article/f0b2a30521094b3bb63056b8a5420c15

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