Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jiaxiang Qu"'
Autor:
Joshua M. Lader, Danielle S. Lent, Gregory E. Morley, Benjamin F. Remo, Frank M. Volpicelli, Steven Giovannone, Jiaxiang Qu, Glenn I. Fishman, Fangyu Liu, Daniel Shin, Jie Zhang
Publikováno v:
Circulation Research. 108:1459-1466
Rationale: Posttranslational phosphorylation of connexin43 (Cx43) has been proposed as a key regulatory event in normal cardiac gap junction expression and pathological gap junction remodeling. Nonetheless, the role of Cx43 phosphorylation in the con
Autor:
Lawrence B. Gardner, David Ron, Ester Zito, Guoxin Kang, Jiaxiang Qu, William A. Coetzee, King Tung Chin, Glenn I. Fishman
Publikováno v:
The FASEB Journal. 25:2583-2591
Two related ER oxidation 1 (ERO1) proteins, ERO1α and ERO1β, dynamically regulate the redox environment in the mammalian endoplasmic reticulum (ER). Redox changes in cysteine residues on intralumenal loops of calcium release and reuptake channels h
Autor:
Bruno H. Stricker, Igor Rudan, Kenneth Rice, Karol Estrada, John M. C. Connell, Thomas Meitinger, Ying A. Wang, Mark Eijgelsheim, Stephan B. Felix, Gerjan Navis, Ozren Polasek, Jingyuan Fu, Fernando Rivadeneira, Joshua C. Bis, Elsayed Z. Soliman, James F. Wilson, Albert V. Smith, Alan F. Wright, Heyo K. Kroemer, Albert Hofman, David S. Siscovick, Steven Giovannone, Caroline Hayward, Fangyu Liu, Alvaro Alonso, Rinse K. Weersma, Aaron R. Folsom, Mark J. Caulfield, Alexander Teumer, Glenn I. Fishman, Christopher J. O'Donnell, Kristin D. Marciante, Martina Müller, Tamara B. Harris, Harold Snieder, Arne Pfeufer, Man Li, Andrew A. Hicks, Moritz F. Sinner, Wiek H. van Gilst, Sarah H. Wild, Nona Sotoodehnia, Jared W. Magnani, Leonard H. van den Berg, Patricia B. Munroe, L. Adrienne Cupples, Paul I.W. de Bakker, Jiaxiang Qu, Roel A. Ophoff, Daniel Levy, Mark P.S. Sie, Toby Johnson, Cornelia M. van Duijn, Lude Franke, Jacqueline C.M. Witteman, Tim D. Spector, Claudia B. Volpato, Folkert W. Asselbergs, Aravinda Chakravarti, Rudolf S N Fehrmann, Xiaowen Lu, Astrid Petersmann, Anna F. Dominiczak, Yalda Jamshidi, W. H. Linda Kao, Anna Köttgen, Susan R. Heckbert, Vilmundur Gudnason, H-Erich Wichmann, Nilesh J. Samani, Marcus Dörr, Christopher Newton-Cheh, Jan A. Kors, Thor Aspelund, Harry J.M. Groen, Irene Mateo Leach, Eric Boerwinkle, Gé van Herpen, Ben A. Oostra, Peter P. Pramstaller, Sandosh Padmanabhan, André G. Uitterlinden, Cisca Wijmenga, Dan E. Arking, Dirk J. van Veldhuisen, Rudolf A. de Boer, Bruce M. Psaty, Christine Schwienbacher, Ilja M. Nolte, Thomas J. Wang, Stefan Kääb, Christian Fuchsberger, Norman Klopp, Lenore J. Launer, Henry Völzke, Siegfried Perz, Aaron Isaacs, Sina A. Gharib, Uwe Völker, Harry Campbell, Jerome I. Rotter, Gerard J. te Meerman, Pim van der Harst
Publikováno v:
Nature Genetics; Vol 42
Nature Genetics, 42(12), 1068-U62. Nature Publishing Group
Sotoodehnia, N, Isaacs, A, de Bakker, P I W, Doerr, M, Newton-Cheh, C, Nolte, I M, van der Harst, P, Mueller, M, Eijgelsheim, M, Alonso, A, Hicks, A A, Padmanabhan, S, Hayward, C, Smith, A V, Polsek, O, Giovannone, S, Fu, J, Magnani, J W, Marciante, K D, Pfeufer, A, Gharib, S A, Teumer, A, Li, M, Bis, J C, Rivadeneira, F, Aspelund, T, Koettgen, A, Johnson, T, Rice, K, Sie, M P S, Wang, Y A, Klopp, N, Fuchsberger, C, Wild, S H, Leach, I M, Estrada, K, Voelker, U, Wright, A, Asselbergs, F W, Qu, J, Chakravarti, A, Sinner, M F, Kors, J A, Petersmann, A, Harris, T B, Soliman, E Z, Munroe, P B, Psaty, B M, Oostra, B A, Cupples, L A, Perz, S, de Boer, R A, Uitterlinden, A G, Voelzke, H, Spector, T D, Liu, F-Y, Boerwinkle, E, Dominiczak, A F, Rotter, J I, van Herpen, G, Levy, D, Wichmann, H-E, van Gilst, W H, Witteman, J C M, Kroemer, H K, Kao, W H L, Heckbert, S R, Meitinger, T, Hofman, A, Campbell, H, Folsom, A R, van Veldhuisen, D J, Schwienbacher, C, O'Donnell, C J, Volpato, C B, Caulfield, M J, Connell, J M, Launer, L, Lu, X, Franke, L, Fehrmann, R S N, Meerman, G T, Groen, H J M, Weersma, R K, van den Berg, L H, Wijmenga, C, Ophoff, R A, Navis, G, Rudan, I, Snieder, H, Wilson, J F, Pramstaller, P P, Siscovick, D S, Wang, T J, Gudnason, V, van Duijn, C M, Felix, S B, Fishman, G I, Jamshidi, Y, Stricker, B H C, Samani, N J, Kaeaeb, S & Arking, D E 2010, ' Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction ', Nature Genetics, vol. 42, no. 12, pp. 1068-1076 . https://doi.org/10.1038/ng.716
Nature Genetics
Nature Genetics, 42(12), 1068-1076. Nature Publishing Group
Nature Genetics, 42(12), 1068-U62. Nature Publishing Group
Sotoodehnia, N, Isaacs, A, de Bakker, P I W, Doerr, M, Newton-Cheh, C, Nolte, I M, van der Harst, P, Mueller, M, Eijgelsheim, M, Alonso, A, Hicks, A A, Padmanabhan, S, Hayward, C, Smith, A V, Polsek, O, Giovannone, S, Fu, J, Magnani, J W, Marciante, K D, Pfeufer, A, Gharib, S A, Teumer, A, Li, M, Bis, J C, Rivadeneira, F, Aspelund, T, Koettgen, A, Johnson, T, Rice, K, Sie, M P S, Wang, Y A, Klopp, N, Fuchsberger, C, Wild, S H, Leach, I M, Estrada, K, Voelker, U, Wright, A, Asselbergs, F W, Qu, J, Chakravarti, A, Sinner, M F, Kors, J A, Petersmann, A, Harris, T B, Soliman, E Z, Munroe, P B, Psaty, B M, Oostra, B A, Cupples, L A, Perz, S, de Boer, R A, Uitterlinden, A G, Voelzke, H, Spector, T D, Liu, F-Y, Boerwinkle, E, Dominiczak, A F, Rotter, J I, van Herpen, G, Levy, D, Wichmann, H-E, van Gilst, W H, Witteman, J C M, Kroemer, H K, Kao, W H L, Heckbert, S R, Meitinger, T, Hofman, A, Campbell, H, Folsom, A R, van Veldhuisen, D J, Schwienbacher, C, O'Donnell, C J, Volpato, C B, Caulfield, M J, Connell, J M, Launer, L, Lu, X, Franke, L, Fehrmann, R S N, Meerman, G T, Groen, H J M, Weersma, R K, van den Berg, L H, Wijmenga, C, Ophoff, R A, Navis, G, Rudan, I, Snieder, H, Wilson, J F, Pramstaller, P P, Siscovick, D S, Wang, T J, Gudnason, V, van Duijn, C M, Felix, S B, Fishman, G I, Jamshidi, Y, Stricker, B H C, Samani, N J, Kaeaeb, S & Arking, D E 2010, ' Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction ', Nature Genetics, vol. 42, no. 12, pp. 1068-1076 . https://doi.org/10.1038/ng.716
Nature Genetics
Nature Genetics, 42(12), 1068-1076. Nature Publishing Group
The QRS interval, from the beginning of the Q wave to the end of the S wave on an electrocardiogram, reflects ventricular depolarization and conduction time and is a risk factor for mortality, sudden death and heart failure. We performed a genomewide
Autor:
Luis I. Garcia, Jie Zhang, Frank M. Volpicelli, Paul D. Lampe, Jiaxiang Qu, Lucrecia Márquez-Rosado, Nefthi Sandeep, Glenn I. Fishman
Publikováno v:
Circulation Research. 104:365-371
Pressure overload is a common pathological insult to the heart and the resulting hypertrophy is an independent risk factor for sudden cardiac death. Gap junction remodeling (GJR) has been described in hypertrophied hearts; however, a detailed underst
Autor:
Nellie Kalcheva, Luis I. Garcia, Sylvia O. Suadicani, Jiaxiang Qu, David C. Spray, Paul D. Lampe, Jie Zhang, Glenn I. Fishman, Zhiyong Wang, Nefthi Sandeep
Publikováno v:
Proceedings of the National Academy of Sciences. 104:20512-20516
Gap junction channels are required for normal cardiac impulse propagation, and gap junction remodeling is associated with enhanced arrhythmic risk. Oculodentodigital dysplasia (ODDD) is a multisystem syndrome due to mutations in the connexin43 ( Cx43
Autor:
Jiaxiang Qu, Kelly Graber, Jibin Zhou, A. Martin Gerdes, Faqian Li, Lu Huber, Xian Ping Yi, Xuejun Wang
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 292:H270-H276
Recent progresses in signal transduction have revealed that beta-catenin signaling controls embryonic development, tumorigenesis, cell shape, and polarity. The role of this pathway in myocyte shape regulation during cardiac hypertrophy and failure is
Autor:
Jasimuddin Ahamed, Alexander Meyer, Jiaxiang Qu, Wei Wang, Lori B. Croft, Jay L. Degen, Barry S. Coller
Publikováno v:
Blood. 119(4)
Circulating platelets contain high concentrations of TGF-β1 in their α-granules and release it on platelet adhesion/activation. We hypothesized that uncontrolled in vitro release of platelet TGF-β1 may confound measurement of plasma TGF-β1 in mic
Autor:
Jiaxiang Qu, Carolina Vasquez, Karen Maass, Joshua M. Lader, Gregory E. Morley, Li Bao, Glenn I. Fishman, Eirini Kefalogianni, William A. Coetzee
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 301(3)
Hypertension is associated with the development of atrial fibrillation; however, the electrophysiological consequences of this condition remain poorly understood. ATP-sensitive K+ (KATP) channels, which contribute to ventricular arrhythmias, are also
Autor:
Xian Ping Yi, Michael D. Schneider, Jibin Zhou, Lisa M. Miller, Xuejun Wang, Hanqiao Zheng, Baojun Dong, Faqian Li, Jiaxiang Qu
Publikováno v:
Journal of molecular and cellular cardiology. 43(3)
In addition to its role in cell adhesion, beta-catenin is an important signaling molecule in the Wnt/Wingless signaling pathway. Recent studies have indicated that beta-catenin is stabilized by hypertrophic stimuli and may regulate cardiac hypertroph
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 290(6)
Focal adhesion kinase (FAK) and FAK-related non-kinase (FRNK) accumulate in the nucleus of cardiac myocytes during hypertensive hypertrophy. Nuclear FAK and FRNK are phosphorylated on different serines and form distinct bright spots. The subnuclear d