Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jiawei Yap"'
Autor:
Yue Gu, Yee Hwa Wong, Chong Wai Liew, Conrad E. Z. Chan, Tanusya M. Murali, Jiawei Yap, Chien Tei Too, Kiren Purushotorman, Maryam Hamidinia, Abbas El Sahili, Angeline T. H. Goh, Rachel Z. C. Teo, Kathryn J. Wood, Brendon J. Hanson, Nicholas R. J. Gascoigne, Julien Lescar, Anantharaman Vathsala, Paul A. MacAry
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA f
Externí odkaz:
https://doaj.org/article/d43685122a4b496da7e60656bb9c199a
Expansion of an Unusual Virtual Memory CD8+ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice
Autor:
Mukul Prasad, Lukasz Wojciech, Joanna Brzostek, Jianfang Hu, Yen Leong Chua, Desmond Wai Hon Tung, Jiawei Yap, Vasily Rybakin, Nicholas R. J. Gascoigne
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Deletion of the gene for Themis affects T cell selection in the thymus, which would be expected to affect the TCR repertoire. We found an increased proportion of cells expressing Vα3.2 (TRAV9N-3) in the peripheral CD8+ T cell population in mice with
Externí odkaz:
https://doaj.org/article/61b4b97101114a488a41db6a2a5ea543
Autor:
Xiang Zhao, Shvetha Sankaran, Jiawei Yap, Chien Tei Too, Zi Zong Ho, Garry Dolton, Mateusz Legut, Ee Chee Ren, Andrew K. Sewell, Antonio Bertoletti, Paul A. MacAry, Joanna Brzostek, Nicholas R. J. Gascoigne
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Coagonism, the ability of nonstimulatory antigens to promote T-cell activation, has been reported in mice. Here the authors show that coagonism also occurs in human CD8 T cells, in which a nonstimulatory HIV GAG peptide enhances a specific T-cell res
Externí odkaz:
https://doaj.org/article/e1513454279048d48870135ba8d4a18d
Autor:
Gautam, Namrata, Wojciech, Lukasz, Jiawei Yap, Yen Leong Chua, Ding, Eyan M. W., Sim, Don C. N., Tan, Alrina S. M., Ahl, Patricia J., Prasad, Mukul, Tung, Desmond W. H., Connolly, John E., Adriani, Giulia, Brzostek, Joanna, Gascoigne, Nicholas R. J.
Publikováno v:
Life Science Alliance; Dec2023, Vol. 6 Issue 12, p1-18, 18p
Autor:
Xiang Zhao, Jiawei Yap, Desmond W. H. Tung, Elijah W. Chen, Namrata Gautam, Nicholas R. J. Gascoigne, Su H. Cho, Shvetha Sankaran, Vasily Rybakin, Guo Fu, Monika Mehta, Yen Leong Chua, Joanna Brzostek
Publikováno v:
Nature Immunology. 21:186-198
T cell homeostasis and functional responsiveness require signals from self-peptide-major histocompatibility complex (self-pMHC) and cytokines, but the mechanisms controlling this signal integration are unknown. Using a conditional deletion of the T c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d28b88827f259091501ce864bdd8f33
https://doi.org/10.1038/s41590-019-0570-3
https://doi.org/10.1038/s41590-019-0570-3
Autor:
Ling Wu, Joanna Brzostek, Previtha Dawn Sakthi Vale, Qianru Wei, Clara K.T. Koh, June Xu Hui Ong, Liang-zhe Wu, Jia Chi Tan, Yen Leong Chua, Jiawei Yap, Yuan Song, Vivian Jia Yi Tan, Triscilla Y.Y. Tan, Junyun Lai, Paul A. MacAry, Nicholas R.J. Gascoigne
Publikováno v:
Cell Reports Medicine. 4:100917
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::884252cdfc306c28ed92aafa065829e6
https://doi.org/10.1016/j.xcrm.2023.100917
https://doi.org/10.1016/j.xcrm.2023.100917
Autor:
Julien Lescar, Angeline T. H. Goh, Yee Hwa Wong, Rachel Zui Chih Teo, Jiawei Yap, Abbas El Sahili, Maryam Hamidinia, Kathryn J. Wood, Conrad E.Z. Chan, Nicholas R. J. Gascoigne, Tanusya M. Murali, Kiren Purushotorman, Brendon J. Hanson, Chong Wai Liew, Chien Tei Too, Anantharaman Vathsala, Yue Gu, Paul A. MacAry
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Our understanding of the conformational and electrostatic determinants that underlie targeting of human leukocyte antigens (HLA) by anti-HLA alloantibodies is principally based upon in silico modelling. Here we provide a biochemical/biophysical and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a12f0fbf74a9110ef580a79127b5631
https://doaj.org/article/d43685122a4b496da7e60656bb9c199a
https://doaj.org/article/d43685122a4b496da7e60656bb9c199a
Autor:
Junyun Lai, Ling Wu, Triscilla Y Y Tan, Shvetha Sankaran, Paul A. MacAry, Jiawei Yap, Qianru Wei, Joanna Brzostek, Nicholas R. J. Gascoigne
Publikováno v:
Cancers, Vol 13, Iss 867, p 867 (2021)
Cancers
Volume 13
Issue 4
Cancers
Volume 13
Issue 4
Simple Summary Chimeric antigen receptors (CARs) redirect T cells without the need for major histocompatibility complex (MHC) restriction. CARs are designed based on T cell receptor (TCR) signaling and the recognition specificities of antibodies. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e90900ed242e9d52ba3ff9a9bc7aa4
https://www.mdpi.com/2072-6694/13/4/867
https://www.mdpi.com/2072-6694/13/4/867
Autor:
Nicholas R J Gascoigne, Ling Wu, Joanna Brzostek, Qianru Wei, Previtha Dawn Sakthi Vale, Clara K.T. Koh, Yen Long Chua, Jiawei Yap, Triscilla Y.Y. Tan, Junyun Lai, Paul A. MacAry
Publikováno v:
The Journal of Immunology. 208:122.02-122.02
CAR-T cells utilize TCR signaling cascades and the recognition functions of antibodies. CAR-T technology has achieved significant success in treatment of certain, primarily liquid, cancers. Nonetheless, many challenges hinder the development of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bca04da23fd8a3371457d84815c0303
https://doi.org/10.4049/jimmunol.208.supp.122.02
https://doi.org/10.4049/jimmunol.208.supp.122.02
Autor:
Jiawei Yap, Lukasz Wojciech, Shvetha Sankaran, Nicholas R. J. Gascoigne, Lois Shi-Qi Hew, Javier Casas, Xiang Zhao, Qianru Wei, Joanna Brzostek
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Proceedings of the National Academy of Sciences of the United States of America
instname
Proceedings of the National Academy of Sciences of the United States of America
Significance Lck is critical for T cell development and activation, as it is the first kinase transducing TCR signaling. Lck can be bound or not bound (free) to the coreceptors (CD4 and CD8) in thymocytes and T cells. After comparing molecular proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da0834c41d512ac161b636ed9a44864
http://hdl.handle.net/10261/226403
http://hdl.handle.net/10261/226403
