Sex differences in islet stress responses support female β cell resilience

Autor: George P. Brownrigg, Yi Han Xia, Chieh Min Jamie Chu, Su Wang, Charlotte Chao, Jiashuo Aaron Zhang, Søs Skovsø, Evgeniy Panzhinskiy, Xiaoke Hu, James D. Johnson, Elizabeth J. Rideout

Publikováno v: Molecular Metabolism, Vol 69, Iss , Pp 101678- (2023)

Objective: Pancreatic β cells play a key role in maintaining glucose homeostasis; dysfunction of this critical cell type causes type 2 diabetes (T2D). Emerging evidence points to sex differences in β cells, but few studies have examined male-female

Externí odkaz: https://doaj.org/article/374b1790b35f4f059d15bf42060d49ea

Human and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia-associated insulin resistance

Autor: Haoning Howard Cen, Bahira Hussein, José Diego Botezelli, Su Wang, Jiashuo Aaron Zhang, Nilou Noursadeghi, Niels Jessen, Brian Rodrigues, James A. Timmons, James D. Johnson

Publikováno v: Cen, H H, Hussein, B, Botezelli, J D, Wang, S, Zhang, J A, Noursadeghi, N, Jessen, N, Rodrigues, B, Timmons, J A & Johnson, J D 2022, ' Human and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia-associated insulin resistance ', The FASEB Journal, vol. 36, no. 1, e22088 . https://doi.org/10.1096/fj.202100497RR

Hyperinsulinemia is commonly viewed as a compensatory response to insulin resistance, yet studies have demonstrated that chronically elevated insulin may also drive insulin resistance. The molecular mechanisms underpinning this potentially cyclic pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf5ed54bfca47cd7bd36d9e08d938cb
https://pubmed.ncbi.nlm.nih.gov/34921686