Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Jiashun Zheng"'
Autor:
Gha-hyun J. Kim, Han Mo, Harrison Liu, Meri Okorie, Steven Chen, Jiashun Zheng, Hao Li, Michelle Arkin, Bo Huang, Su Guo
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Parkinson’s disease (PD) is the second most common neurodegenerative disorder with prominent dopamine (DA) neuron degeneration. PD affects millions of people worldwide, but currently available therapies are limited to temporary relief of symptoms.
Externí odkaz:
https://doaj.org/article/5e66ae3b44404460ab4da8835c1622fe
Autor:
Gha-Hyun J Kim, Han Mo, Harrison Liu, Zhihao Wu, Steven Chen, Jiashun Zheng, Xiang Zhao, Daryl Nucum, James Shortland, Longping Peng, Mannuel Elepano, Benjamin Tang, Steven Olson, Nick Paras, Hao Li, Adam R Renslo, Michelle R Arkin, Bo Huang, Bingwei Lu, Marina Sirota, Su Guo
Publikováno v:
eLife, Vol 10 (2021)
Parkinson’s disease (PD) is a common neurodegenerative disorder without effective disease-modifying therapeutics. Here, we establish a chemogenetic dopamine (DA) neuron ablation model in larval zebrafish with mitochondrial dysfunction and robustnes
Externí odkaz:
https://doaj.org/article/1a2b18fbbd014e52b754a5691eee90b7
Autor:
Baoming Nie, Tao Nie, Xiaoyan Hui, Ping Gu, Liufeng Mao, Kuai Li, Ran Yuan, Jiashun Zheng, Haixia Wang, Ke Li, Shibing Tang, Yu Zhang, Tao Xu, Aimin Xu, Donghai Wu, Sheng Ding
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 624-635 (2017)
Brown adipose tissue (BAT) has attracted considerable research interest because of its therapeutic potential to treat obesity and associated metabolic diseases. Augmentation of brown fat mass and/or its function may represent an attractive strategy t
Externí odkaz:
https://doaj.org/article/72966afad4804197884b6d46c366274c
Autor:
Zhaojun An, Peng Liu, Jiashun Zheng, Chaozeng Si, Tianda Li, Yang Chen, Tianhua Ma, Michael Q. Zhang, Qi Zhou, Sheng Ding
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1986-2000.e8 (2019)
Summary: Ectopic expression of Oct4, Sox2, Klf4, and c-Myc can reprogram differentiated somatic cells into induced pluripotent stem cells (iPSCs). For years, Oct4 has been considered the key reprogramming factor core of the four factors. Here, we cha
Externí odkaz:
https://doaj.org/article/4b7a614ebe984ef78e3ec26f316908f5
Autor:
Jiashun Zheng, Joris J Benschop, Michael Shales, Patrick Kemmeren, Jack Greenblatt, Gerard Cagney, Frank Holstege, Hao Li, Nevan J Krogan
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-12 (2010)
Abstract The regulation of gene expression is, in large part, mediated by interplay between the general transcription factors (GTFs) that function to bring about the expression of many genes and site‐specific DNA‐binding transcription factors (ST
Externí odkaz:
https://doaj.org/article/b8e47565a7844e6393c7a94ef43ea817
Autor:
Vera Huang, Jiashun Zheng, Zhongxia Qi, Ji Wang, Robert F. Place, Jingwei Yu, Hao Li, Long-Cheng Li
Publikováno v:
PLoS Genetics, Vol 10, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/cd0cb9fe6b684a7798fde282f6b483de
Autor:
Vera Huang, Jiashun Zheng, Zhongxia Qi, Ji Wang, Robert F Place, Jingwei Yu, Hao Li, Long-Cheng Li
Publikováno v:
PLoS Genetics, Vol 9, Iss 9, p e1003821 (2013)
Argonaute proteins are often credited for their cytoplasmic activities in which they function as central mediators of the RNAi platform and microRNA (miRNA)-mediated processes. They also facilitate heterochromatin formation and establishment of repre
Externí odkaz:
https://doaj.org/article/7a48716830b342328a44555936330b35
Autor:
Philipp Kimmig, Marcy Diaz, Jiashun Zheng, Christopher C Williams, Alexander Lang, Tomas Aragón, Hao Li, Peter Walter
Publikováno v:
eLife, Vol 1 (2012)
The unfolded protein response (UPR) monitors the protein folding capacity of the endoplasmic reticulum (ER). In all organisms analyzed to date, the UPR drives transcriptional programs that allow cells to cope with ER stress. The non-conventional spli
Externí odkaz:
https://doaj.org/article/c91323c6c56c4923a9dbdfd8e493f3d4
Publikováno v:
Journal of Soil Science and Plant Nutrition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aeed1bc8241537113cae97751be8ca1d
https://doi.org/10.1007/s42729-023-01251-1
https://doi.org/10.1007/s42729-023-01251-1
Rejuvenation, long a quixotic dream, recently became a possibility through exciting new approaches to counteract aging. For example, parabiosis and partial reprogramming through overexpressing four stem cell transcription factors (Yamanaka factors) b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f40c7a024470d91e179ac3d684a8546
https://doi.org/10.1101/2022.11.20.517270
https://doi.org/10.1101/2022.11.20.517270
