Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jiaqin Yao"'
Publikováno v:
BMJ Open, Vol 12, Iss 12 (2022)
Objectives To determine the prevalence of possible sarcopenia and its association with other conditions in older adults in Bengbu, China.Design, setting and participants A cross-sectional study of 1082 community-dwelling Chinese people aged at least
Externí odkaz:
https://doaj.org/article/afc130fce2b7413ea5efc11c8e38d9bc
Publikováno v:
BMJ open. 12(12)
ObjectivesTo determine the prevalence of possible sarcopenia and its association with other conditions in older adults in Bengbu, China.Design, setting and participantsA cross-sectional study of 1082 community-dwelling Chinese people aged at least 60
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 550:109-121
Long-term exposure to synthetic and endogenous estrogens has been associated with the development of cancer in several tissues. One potential mechanism of estrogen carcinogenesis involves catechol formation and these catechols are further oxidized to
Autor:
Emily Pisha, Debra A. Tonetti, Xuemei Liu, Dan Yao, Joanna E. Burdette, Yan Li, Judy L. Bolton, Jiaqin Yao
Publikováno v:
Chemical Research in Toxicology. 16:832-837
The antiestrogen, tamoxifen, has been extensively used in the treatment and prevention of breast cancer. Although tamoxifen showed benefits in the chemotherapy and chemoprevention of breast cancer, epidemiological studies in both tamoxifen-treated br
Autor:
Jiaqin Yao, Gregory G. Oakley, Michael P. Carty, Kathleen Dixon, Steve M. Patrick, John J. Turchi
Publikováno v:
Biochemistry. 42:3255-3264
The heterotrimeric DNA-binding protein, replication protein A (RPA), consists of 70-, 34-, and 14-kDa subunits and is involved in maintaining genomic stability by playing key roles in DNA replication, repair, and recombination. RPA participates in th
Publikováno v:
Toxicology letters. 154(3)
Excessive exposure to synthetic and endogenous estrogens has been associated with the development of cancer in several tissues including the breast. 4-Hydroxyequilenin (4-OHEN), a major catechol metabolite of equine estrogens present in Premarin, an
Autor:
Andrew D. Mesecar, Jiaqin Yao, Linning Yu, Dejan Nikolic, James D. Yager, J L Bolton, Richard B. van Breemen, Yan Li, Minsun Chang
Publikováno v:
Chemical research in toxicology. 17(4)
Catechol-O-methyltransferase (COMT) plays an important role in the inactivation of biologically active and toxic catechols. It has been shown that COMT is genetically polymorphic with a wild-type and variant form where a valine has been substituted w
Autor:
Xuemei Liu, Joanna E. Burdette, Emily Pisha, Jiaqin Yao, Hong Liu, Steven M. Swanson, Fagen Zhang, Cassia R. Overk, Judy L. Bolton, Yan Li, Richard B. van Breemen
Publikováno v:
Chemical research in toxicology. 16(6)
Estrogen replacement therapy has been correlated with an increased risk for developing breast and endometrial cancers. One potential mechanism of estrogen carcinogenesis involves metabolism of estrogens to 2- and 4-hydroxylated catechols, which are f
Autor:
Xuemei Liu, Emily Pisha, Jiaqin Yao, Richard B. van Breemen, Yanan Yang, Judy L. Bolton, Yousheng Hua
Publikováno v:
Chemical research in toxicology. 15(4)
Excessive exposure to synthetic and endogenous estrogens has been associated with the development of cancer in several tissues. 4-Hydroxyequilenin (4-OHEN), a major metabolite of equine estrogens present in estrogen replacement formulations, has been
Publikováno v:
Environmental and molecular mutagenesis. 38(1)
The human skin cancer-prone disease xeroderma pigmentosum variant (XPV) results from a mutation in the human RAD30 gene, which encodes the lesion bypass DNA polymerase eta. XPV cells are characterized by delayed completion of DNA replication and incr