Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jiaoyi Chen"'
Autor:
Huijun He, Yu Zhong, Honglian Wang, Patrick Ming-Kuen Tang, Vivian Weiwen Xue, Xiaocui Chen, Jiaoyi Chen, Xiaoru Huang, Cheng Wang, Huiyao Lan
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11396 (2023)
Transforming growth factor-β (TGF-β)/Smad3 signaling has been shown to play important roles in fibrotic and inflammatory diseases. However, the role of Smad3 in dyslipidemia and non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes remains u
Externí odkaz:
https://doaj.org/article/f8725c3623b44ff1b6197d4b5af1ca46
Autor:
Jiaoyi Chen, Xiao Ru Huang, Fuye Yang, Wai Han Yiu, Xueqing Yu, Sydney C. W. Tang, Hui Yao Lan
Publikováno v:
Advanced Science, Vol 9, Iss 18, Pp n/a-n/a (2022)
Abstract Previously, this study demonstrates the critical role of myeloid specific TLR4 in macrophage‐mediated progressive renal injury in anti‐glomerular basement membrane (anti‐GBM) crescentic glomerulonephritis (cGN); however, the underlying
Externí odkaz:
https://doaj.org/article/3a2da85265024b5ebd8877932fe364a6
Autor:
Qixia Shen, Yucheng Wang, Jiaoyi Chen, Lifeng Ma, Xiaoru Huang, Sydney C. W. Tang, Huiyao Lan, Hong Jiang, Jianghua Chen
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Allograft rejection is a common immunological feature in renal transplantation and is associated with reduced graft survival. A mouse renal allograft rejection model was induced and single-cell RNA sequencing (scRNA-seq) data of CD45+ leukocytes in k
Externí odkaz:
https://doaj.org/article/6340c25fe1354964b3b602a9cc2f778a
Autor:
Philip Chiu-Tsun Tang, Ying-Ying Zhang, Jane Siu-Fan Li, Max Kam-Kwan Chan, Jiaoyi Chen, Ying Tang, Yiming Zhou, Dongmei Zhang, Kam-Tong Leung, Ka-Fai To, Sydney Chi-Wai Tang, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
Non-Coding RNA, Vol 8, Iss 3, p 36 (2022)
Transforming growth factor-β (TGF-β) is a crucial pathogenic mediator of inflammatory diseases. In tissue fibrosis, TGF-β regulates the pathogenic activity of infiltrated immunocytes and promotes extracellular matrix production via de novo myofibr
Externí odkaz:
https://doaj.org/article/54e6ce1d99cf439fa1f40b6f1d388ae0
Autor:
Wai Han Yiu, Sarah W.Y. Lok, Rui Xue, Jiaoyi Chen, Kar Neng Lai, Hui Yao Lan, Sydney C.W. Tang
Publikováno v:
Clinical Science. 137:317-331
Kidney inflammation contributes to the progression of chronic kidney disease (CKD). Modulation of Toll-like receptor 4 (TLR4) signaling is a potential therapeutic strategy for this pathology, but the regulatory mechanisms of TLR4 signaling in kidney
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a30d6abef74fdf65fab89ee4331afca
https://doi.org/10.1042/cs20220537
https://doi.org/10.1042/cs20220537
Autor:
Sarah W Y Lok, Wai Han Yiu, Yixin Zou, Rui Xue, Hongyu Li, Jingyuan Ma, Jiaoyi Chen, Loretta Y Y Chan, Kar Neng Lai, Sydney C W Tang
Publikováno v:
Nephrology Dialysis Transplantation.
Background Thromboembolic events are prevalent in chronic kidney disease (CKD) patients due to increased thrombin generation leading to a hypercoagulable state. We previously demonstrated that inhibition of protease-activated receptor-1 (PAR-1) by vo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65e0d66187142cc9a912265febfa8299
https://doi.org/10.1093/ndt/gfad051
https://doi.org/10.1093/ndt/gfad051
Autor:
Xueqing Yu, Wai Han Yiu, Hui-Yao Lan, Jiaoyi Chen, Sydney C.W. Tang, Xiao R. Huang, Fuye Yang
Publikováno v:
Cellular and Molecular Life Sciences
Myeloid cells and TLR4 play a critical role in acute kidney injury. This study investigated the regulatory role and mechanisms of myeloid TLR4 in experimental anti-glomerular basement membrane (GBM) glomerulonephritis (GN). Anti-GBM GN was induced in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f196168b69a6db402a39ea291eae3c51
http://europepmc.org/articles/PMC8558180
http://europepmc.org/articles/PMC8558180
Autor:
Guang-Yu Lian, Yingpeng Wan, Thomas Shiu-Kwong Mak, Qing-Ming Wang, Jinfeng Zhang, Jiaoyi Chen, Zi-Ying Wang, Min Li, Patrick Ming-Kuen Tang, Xiao-Ru Huang, Chun-Sing Lee, Xue-Qing Yu, Hui-Yao Lan
Publikováno v:
Biomaterials. 288
Transforming growth factor β (TGF-β) is a well-known key mediator for the progression and metastasis of lung carcinoma. However, cost-effective anti-TGF-β therapeutics for lung cancer remain to be explored. Specifically, the low efficacy in drug d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f910148bcf98cb06a6cc722eb201427
https://pubmed.ncbi.nlm.nih.gov/35995622
https://pubmed.ncbi.nlm.nih.gov/35995622
Autor:
Xiao-Ru Huang, Jiaoyi Chen, Michael Bader, Jinxiu Meng, Hui-Yao Lan, Jun Ni, Josef M. Penninger, Erik Fung, Xue-Qing Yu, Fuye Yang
Publikováno v:
Journal of Cellular and Molecular Medicine
Angiotensin‐converting enzyme‐2 (ACE2) and Mas receptor are the major components of the ACE2/Ang 1‐7/Mas axis and have been shown to play a protective role in hypertension and hypertensive nephropathy individually. However, the effects of dual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5d5be36230f02abafcd9f09c246133
https://doi.org/10.1111/jcmm.15914
https://doi.org/10.1111/jcmm.15914
Autor:
Max Kam-Kwan Chan, Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Alex Siu-Wing Chan, Johnny Yuk-Yeung Ho, Tony Pak-Tik Lin, Jiaoyi Chen, Kam-Tong Leung, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
Cancer Letters. 550:215925
Transforming growth factor-β (TGF-β) signaling shows important roles in both physiology and pathology, especially in the progression of inflammatory diseases including cancer. Interestingly, TGF-β was first reported as a cancer suppressor, but inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b967aa4fd02aa8b23f8625898ff2fe51
https://doi.org/10.1016/j.canlet.2022.215925
https://doi.org/10.1016/j.canlet.2022.215925