Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jiaolin Wen"'
Publikováno v:
MedComm, Vol 5, Iss 9, Pp n/a-n/a (2024)
Abstract Head and neck cancer (HNC) is a highly aggressive type of tumor characterized by delayed diagnosis, recurrence, metastasis, relapse, and drug resistance. The occurrence of HNC were associated with smoking, alcohol abuse (or both), human papi
Externí odkaz:
https://doaj.org/article/d5cb07225bb24646908885e274b4547a
Autor:
Zejiang Zhu, Jiaolin Wen, Yaohui Xu, Heying Pei, Dan Li, Minghai Tang, Peng Bai, Jun He, Zhuang Yang, Lijuan Chen
Publikováno v:
Annals of Medicine, Vol 54, Iss 1, Pp 743-753 (2022)
Background: Previous studies have proven that Purinostat Mesylate (PM) is a new HDAC inhibitor and exhibits significant antitumor efficacy. However, the clinical application of PM was greatly limited by its poor solubility in water and low bioavailab
Externí odkaz:
https://doaj.org/article/79621c5371944ab3ab0dc32252cd9bfa
Autor:
Jiaolin Wen, Neng Qiu, Zejiang Zhu, Peng Bai, Mengshi Hu, Wenyan Qi, Yan Liu, Ailin Wei, Lijuan Chen
Publikováno v:
Drug Delivery, Vol 28, Iss 1, Pp 1055-1066 (2021)
Given the maturation of small-interfering RNA (siRNA) techniques with nanotechnology, and because overexpression of human programmed death-ligand 1 (PD-L1) is crucial for T cell inactivation and immunosuppression of the tumor microenvironment, applic
Externí odkaz:
https://doaj.org/article/c152ffbe18044135a9ff3b00f8c066e9
Autor:
Jiaolin Wen, Xianhuo Wang, Heying Pei, Caifeng Xie, Neng Qiu, Shucai Li, Wenwen Wang, Xia Cheng, Lijuan Chen
Publikováno v:
Journal of Pharmacological Sciences, Vol 128, Iss 3, Pp 116-124 (2015)
Honokiol (HK), a biphenolic neolignan isolated from Magnolia officinalis, has been reported to possess anti-inflammatory and anti-angiogenic activaties. In this study, our aim was to investigate anti-psoriatic activities of HK and the involved mechan
Externí odkaz:
https://doaj.org/article/1a0ff7bf0dcf43ae93eb615fad59ac9c
Autor:
Jingjing Wang, Zhuang Yang, Jiaolin Wen, Feng Ma, Fang Wang, Kun Yu, Minghai Tang, Wenshuang Wu, Yinfeng Dong, Xia Cheng, Chunlai Nie, Lijuan Chen
Publikováno v:
Journal of Pharmacological Sciences, Vol 126, Iss 3, Pp 198-207 (2014)
Abstract.: SKLB-M8, a derivative of millepachine, showed significant anti-proliferative effects in melanoma cell lines. In this study, we investigated the anti-melanoma and anti-angiogenic activity of SKLB-M8 on three melanoma cell lines (A2058, CHL-
Externí odkaz:
https://doaj.org/article/73fb9f1c0eea4d268f5a1e5375318cf0
Autor:
Yike Yuan, Yuwei Zhao, Shengchang Xin, Ni Wu, Jiaolin Wen, Song Li, Lijuan Chen, Yuquan Wei, Hanshuo Yang, Shuo Lin
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60266 (2013)
The Hedgehog (Hh) pathway inhibitors have shown great promise in cancer therapeutics. SANT75, a novel compound we previously designed to specially inhibit the Smoothened (SMO) protein in the Hh pathway, has greater inhibitory potency than many of com
Externí odkaz:
https://doaj.org/article/6107fa4c974c42a2ada47f6afb8185a2
Autor:
Xianhuo Wang, Xingmei Duan, Guangli Yang, Xiaoyan Zhang, Linyu Deng, Hao Zheng, Chongyang Deng, Jiaolin Wen, Ning Wang, Cheng Peng, Xia Zhao, Yuquan Wei, Lijuan Chen
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18490 (2011)
BackgroundGliosarcoma is one of the most common malignant brain tumors, and anti-angiogenesis is a promising approach for the treatment of gliosarcoma. However, chemotherapy is obstructed by the physical obstacle formed by the blood-brain barrier (BB
Externí odkaz:
https://doaj.org/article/dece1e78bedd4ac4bc8ff29f1753f881
Autor:
Zejiang Zhu, Neng Qiu, Peng Bai, Li Yang, Lijuan Chen, Zhoufeng Wang, Huili Liu, Xiaoming Shu, Jiaolin Wen
Publikováno v:
Current Pharmaceutical Design. 26:4338-4348
Background: PEGylation of stealth liposomes elevates their stability and prolongs plasma half-life. Stealth liposomes modified with targeting ligands are expected to be ideal drug delivery carriers. Objective: To encapsulate docetaxel in tbFGF (trunc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b068dca8408b837415e6af67604674
https://doi.org/10.2174/1381612826666200423093357
https://doi.org/10.2174/1381612826666200423093357
Autor:
Qiaoqiao Hu, Jiaolin Wen, Ting Niu, Minghai Tang, Zhengying Su, Jun He, Jianhong Yang, Peng Bai, Huili Liu, Zejiang Zhu, Lijuan Chen
Publikováno v:
Journal of Biomedical Nanotechnology. 15:1515-1531
In our previous study, we identified a class of 4-substituted coumarins as a powerful microtubule inhibitors binding to the colchicine site of β-tubulin. H6 showed potent anti-proliferative ability with IC50 values from 7 to 47 nM, and remarkable ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f3448600a53b4bf1a82db78ad082d8c
https://doi.org/10.1166/jbn.2019.2797
https://doi.org/10.1166/jbn.2019.2797
Autor:
Jianhong Yang, Liang Ouyang, Linyu Yang, Min Zhao, Wei Yan, Minghai Tang, Yamei Yu, Zhuang Yang, Yong Li, Weimin Li, Haoyu Ye, Zhoufeng Wang, Yuquan Wei, Haoche Wei, Jiaolin Wen, Lijuan Chen, Qiang Chen, Lu Niu, Heying Pei
Publikováno v:
Science Advances
A novel binding site on α-tubulin shows promise as a target for a new generation of anticancer drugs.
Microtubules, composed of αβ-tubulin heterodimers, have remained popular anticancer targets for decades. Six known binding sites on tubulin
Microtubules, composed of αβ-tubulin heterodimers, have remained popular anticancer targets for decades. Six known binding sites on tubulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9059f1aa9cd7c0166f167d56b0bfeb97
http://europepmc.org/articles/PMC8133757
http://europepmc.org/articles/PMC8133757