Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jianzhang Yang"'
Autor:
Jianzhang Yang, Yu Chang, Jean Ching-Yi Tien, Zhen Wang, Yang Zhou, Pujuan Zhang, Weixue Huang, Josh Vo, Ingrid J. Apel, Cynthia Wang, Victoria Zhixuan Zeng, Yunhui Cheng, Shuqin Li, George Xiaoju Wang, Arul M. Chinnaiyan, Ke Ding
Publikováno v:
Journal of Medicinal Chemistry. 65:11066-11083
Selective degradation of the cyclin-dependent kinases 12 and 13 (CDK12/13) presents a novel therapeutic opportunity for triple-negative breast cancer (TNBC), but there is still a lack of dual CDK12/13 degraders. Here, we report the discovery of the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729f4d2ce8c183f7d15b5ab3aef4e7c9
https://doi.org/10.1021/acs.jmedchem.2c00384
https://doi.org/10.1021/acs.jmedchem.2c00384
Autor:
Shuangshuang, Shu, Han, Liu, Jianzhang, Yang, Haie, Tang, Hao, Li, Zhuoliang, Liu, Miaomiao, Zhou, Fengxin, Zhu, Zheng, Hu, Ke, Ding, Xiaoyun, Lu, Jing, Nie
Publikováno v:
Translational Research. 246:49-65
ZAK (sterile alpha motif and leucine zipper-containing kinase) is a newly discovered member of the subfamily of mitogen-activated protein kinase kinase kinases (MAP3Ks). The role of ZAK in kidney disease remains largely unknown. In this study, we sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e9b821f8d2dd9dfd44219a6d3f8dca
https://doi.org/10.1016/j.trsl.2022.03.002
https://doi.org/10.1016/j.trsl.2022.03.002
Autor:
Yu Chang, Jianzhang Yang, Jean Ching-Yi Tien, Zhen Wang, Yang Zhou, Pujuan Zhang, Weixue Huang, Josh Vo, Ingrid J. Apel, Cynthia Wang, Victoria Zhixuan Zeng, Yunhui Cheng, Shuqin Li, George Xiaoju Wang, Ke Ding, Arul M. Chinnaiyan
Publikováno v:
Cancer Research. 83:3428-3428
Selective degradation of the cyclin-dependent kinases 12 and 13 (CDK12/13) presents a novel therapeutic opportunity for triple-negative breast cancer (TNBC), but there is still a lack of dual CDK12/13 degraders. Here, we report the discovery of the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06f171229bb1d29cb371e47729da5429
https://doi.org/10.1158/1538-7445.am2023-3428
https://doi.org/10.1158/1538-7445.am2023-3428
Autor:
Ke Ding, Jinfeng Luo, Cai-Hong Yun, Jianzhang Yang, Yanhui Huang, Zhengchao Tu, Marthandam Asokan Shibu, Lulu Kong, Xiaoyun Lu, Chih Yang Huang, Farheen BadrealamKhan
Publikováno v:
Journal of Medicinal Chemistry. 63:2114-2130
ZAK is a new promising target for discovery of drugs with activity against antihypertrophic cardiomyopathy (HCM). A series of 1,2,3-triazole benzenesulfonamides were designed and synthesized as selective ZAK inhibitors. One of these compounds, 6p bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f23ac5b1a579fca94b9bd9b4dfffdd
https://doi.org/10.1021/acs.jmedchem.9b00664
https://doi.org/10.1021/acs.jmedchem.9b00664
Publikováno v:
2020 Cross Strait Radio Science & Wireless Technology Conference (CSRSWTC).
An offset-pole periodic cusped magnet (PCM) focusing system for an H-band (220–325 GHz) traveling wave tube was designed and optimized using CST-PS. It is composed of 82 magnetic blocks and 84 poles. The diffusion of the sheet electron beam is effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b01d08d8c374af100b2b1b19e099ec73
https://doi.org/10.1109/csrswtc50769.2020.9372491
https://doi.org/10.1109/csrswtc50769.2020.9372491
Publikováno v:
The Journal of Physical Chemistry C. 119:8980-8990
New structure–function correlations are revealed in poly(3-alkyl-thienylenevinylene) (P3ATV) derivatives using resonance Raman spectroscopy techniques. P3ATVs are prototype conjugated polymers that have received increased attention recently due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cef6c80cb0a306a709bf4ffd522d7ccf
https://doi.org/10.1021/acs.jpcc.5b02166
https://doi.org/10.1021/acs.jpcc.5b02166
Autor:
Jianzhang Yang, Joseph Raymond Winkle, Jacob J. Plattner, Yong-Kang Zhang, Zhixin Ge, Eric E. Easom, Jianxin Cao, Terry William Balko, Yasheen Zhou, Defauw Jean Marie, W. Hunter White, Tsutomu Akama
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(13)
Novel isoxazoline amide benzoxaboroles were designed and synthesized to optimize the ectoparasiticide activity of this chemistry series against ticks and fleas. The study identified an orally bioavailable molecule, (S)-N-((1-hydroxy-3,3-dimethyl-1,3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5faf93f91bfd392cc2d3f56f43e76a
https://pubmed.ncbi.nlm.nih.gov/27210432
https://pubmed.ncbi.nlm.nih.gov/27210432