Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jianying Kiser"'
Autor:
Prem Singh Kaushal, Qun Wan, Chris G. Dealwis, Jianying Kiser, Hai Xu, James W. Fairman, Andrew Zhang, Sanath R. Wijerathna, Md. Faiz Ahmad
Publikováno v:
Pharmaceuticals, Vol 4, Iss 10, Pp 1328-1354 (2011)
Ribonucleotide reductase (RR) is a crucial enzyme in de novo DNA synthesis, where it catalyses the rate determining step of dNTP synthesis. RRs consist of a large subunit called RR1 (α), that contains two allosteric sites and one catalytic site, and
Externí odkaz:
https://doaj.org/article/cc9736ee1fed4dd88e3d13b9070a7567
Autor:
Sathishkumar Chandrakumar, Irene Santiago Tierno, Mahesh Agarwal, Emma M. Lessieur, Yunpeng Du, Jie Tang, Jianying Kiser, Xiao Yang, Timothy S. Kern, Kaustabh Ghosh
Vascular inflammation is known to cause degeneration of retinal vessels in early diabetic retinopathy (DR). Past studies investigating these diabetes-induced vascular abnormalities have focused primarily on the role of molecular or biochemical cues.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d9442d0db3619220f088a36a09ad539
https://doi.org/10.1101/2022.12.18.520943
https://doi.org/10.1101/2022.12.18.520943
Publikováno v:
Diabetologia. 65(10)
Induction of intercellular adhesion molecule-1 (ICAM-1) has been implicated in the development of macrovascular and microvascular diseases such as diabetic retinopathy. Lesions of diabetic retinopathy are unique to the retina but the reason for this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08dce603d105caf388f580aa35a48546
https://pubmed.ncbi.nlm.nih.gov/35852587
https://pubmed.ncbi.nlm.nih.gov/35852587
Autor:
Timothy S. Kern, Xiangyi Wen, Bruce A. Berkowitz, Yunpeng Du, Masaru Miyagi, Emma M. Lessieur, Wallace B. Thoreson, Aicha Saadane, Jianying Kiser
Publikováno v:
Am J Pathol
This study tested the hypothesis that diabetes promotes a greater than normal cytosolic calcium level in rod cells that activates a Ca(2+)-sensitive protease, calpain, resulting in oxidative stress and inflammation, two pathogenic factors of early di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e226b5d1e9ed3abd145ed8b53c9f327
https://pubmed.ncbi.nlm.nih.gov/34214506
https://pubmed.ncbi.nlm.nih.gov/34214506
Autor:
Emma M. Lessieur, Timothy S. Kern, Jianying Kiser, Yunpeng Du, Aicha Saadane, Haitao Liu, Jie Tang
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Previous studies indicate that leukocytes, notably neutrophils, play a causal role in the capillary degeneration observed in diabetic retinopathy (DR), however, the mechanism by which they cause such degeneration is unknown. Neutrophil elasta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87623d1fe539a8128b59c2b0dc515cc3
https://doi.org/10.1167/iovs.62.13.7
https://doi.org/10.1167/iovs.62.13.7