Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Jianyi Yin"'
Autor:
Amir Kumar Singh, Ritesh Kumar, Jianyi Yin, John F. Brooks II, Mahesh Kathania, Sandip Mukherjee, Jitendra Kumar, Kevin P. Conlon, Venkatesha Basrur, Zhe Chen, Xianlin Han, Lora V. Hooper, Ezra Burstein, K. Venuprasad
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Th17 cells that produce Interleukin IL-17 are pathogenic in many human diseases, including inflammatory bowel disease, but are, paradoxically, essential for maintaining the integrity of the intestinal barrier in a non-inflammatory state. How
Externí odkaz:
https://doaj.org/article/befedf1f83644092980fd717763deaa0
Autor:
Varsha Singh, Kelli Johnson, Jianyi Yin, Sun Lee, Ruxian Lin, Huimin Yu, Julie In, Jennifer Foulke-Abel, Nicholas C. Zachos, Mark Donowitz, Yan Rong
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 219-232 (2022)
Background & Aims: One of the features of ulcerative colitis (UC) is a defect in the protective mucus layer. This has been attributed to a reduced number of goblet cells (GCs). However, it is not known whether abnormal GC mucus secretion also contrib
Externí odkaz:
https://doaj.org/article/25d5ffea77704c5ea3915cea053f586e
Autor:
Chung-Ming Tse, Jianyi Yin, Varsha Singh, Rafiquel Sarker, Ruxian Lin, Alan S. Verkman, Jerrold R. Turner, Mark Donowitz
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 3, Pp 641-653 (2019)
Background & Aims: SLC26A3 (DRA) is an electroneutral Cl-/HCO3- exchanger that is present in the apical domain of multiple intestinal segments. An area that has continued to be poorly understood is related to DRA regulation in acute adenosine 3′,5
Externí odkaz:
https://doaj.org/article/565a8fd73e2844858353410d7094d254
Autor:
Nesrin M. Hasan, Kelli F. Johnson, Jianyi Yin, Nicholas W. Baetz, Lea Fayad, Vadim Sherman, Sarah E. Blutt, Mary K. Estes, Vivek Kumbhari, Nicholas C. Zachos, Olga Kovbasnjuk
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101129- (2021)
Objective: The mechanisms behind the efficacy of bariatric surgery (BS) for treating obesity and type 2 diabetes, particularly with respect to the influence of the small bowel, remain poorly understood. In vitro and animal models are suboptimal with
Externí odkaz:
https://doaj.org/article/25e0bcf24af540379f8523f80e6a8a1a
Autor:
Julie G. In, Jianyi Yin, Roger Atanga, Michele Doucet, Robert N. Cole, Lauren DeVine, Mark Donowitz, Nicholas C. Zachos, Sarah E. Blutt, Mary K. Estes, Olga Kovbasnjuk
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101618- (2020)
Summary: Intestinal regeneration and crypt hyperplasia after radiation or pathogen injury relies on Wnt signaling to stimulate stem cell proliferation. Mesenchymal Wnts are essential for homeostasis and regeneration in mice, but the role of epithelia
Externí odkaz:
https://doaj.org/article/88f2b12376d14908aab26aa626367e78
Autor:
Magdalena Kasendra, Raymond Luc, Jianyi Yin, Dimitris V Manatakis, Gauri Kulkarni, Carolina Lucchesi, Josiah Sliz, Athanasia Apostolou, Laxmi Sunuwar, Jenifer Obrigewitch, Kyung-Jin Jang, Geraldine A Hamilton, Mark Donowitz, Katia Karalis
Publikováno v:
eLife, Vol 9 (2020)
Induction of intestinal drug metabolizing enzymes can complicate the development of new drugs, owing to the potential to cause drug-drug interactions (DDIs) leading to changes in pharmacokinetics, safety and efficacy. The development of a human-relev
Externí odkaz:
https://doaj.org/article/d50dcbcf666140a997178741be620615
Autor:
Jianyi Yin, Chung-Ming Tse, Leela Rani Avula, Varsha Singh, Jennifer Foulke-Abel, Hugo R. de Jonge, Mark Donowitz
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 591-609 (2018)
Background & Aims: Human enteroids present a novel tool to study human intestinal ion transport physiology and pathophysiology. The present study describes the contributions of Cl- and HCO3- secretion to total cyclic adenosine monophosphate (cAMP)-st
Externí odkaz:
https://doaj.org/article/4f92a8c3a890408d92789264e3bdcf46
Autor:
C. Ming Tse, Julie G. In, Jianyi Yin, Mark Donowitz, Michele Doucet, Jennifer Foulke-Abel, Fernando Ruiz-Perez, James P. Nataro, Nicholas C. Zachos, James B. Kaper, Olga Kovbasnjuk
Publikováno v:
Toxins, Vol 10, Iss 9, p 351 (2018)
One of the characteristic manifestations of Shiga-toxin-producing Escherichia coli (E. coli) infection in humans, including EHEC and Enteroaggregative E. coli O104:H4, is watery diarrhea. However, neither Shiga toxin nor numerous components of the ty
Externí odkaz:
https://doaj.org/article/381e15c12afc48dcbaeddf0037588a7d
Autor:
Jennifer Foulke-Abel, Kelli F. Johnson, Mark Donowitz, Ruxian Lin, Nicholas C. Zachos, Sun Lee, Varsha Singh, Jianyi Yin, Huimin Yu, Yan Rong, Julie In
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 219-232 (2022)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims One of the features of ulcerative colitis (UC) is a defect in the protective mucus layer. This has been attributed to a reduced number of goblet cells (GCs). However, it is not known whether abnormal GC mucus secretion also contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9c60b3f44f4ec5b1ede8c2e9a502aa
https://doi.org/10.1016/j.jcmgh.2021.08.010
https://doi.org/10.1016/j.jcmgh.2021.08.010
Autor:
Katia Karalis, Chung-Ming Tse, Jianyi Yin, Magdalena Kasendra, C. Conover Talbot, Laxmi Sunuwar, Huimin Yu, Robert N. Cole, Mark Donowitz, Tatiana Boronina
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
There is increasing evidence that the study of normal human enteroids duplicates many known aspects of human intestinal physiology. However, this epithelial cell-only model lacks the many nonepithelial intestinal cells present in the gastrointestinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c944436d70b71dd3c5ff66c4fbb73d
https://doi.org/10.1152/ajpgi.00282.2020
https://doi.org/10.1152/ajpgi.00282.2020