Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Jianxiu Yu"'
Autor:
Haihua Yuan, Renjie Cai, Biying Chen, Qian Wang, Mengting Wang, Junyi An, Weishu An, Ye Tao, Jianxiu Yu, Bin Jiang, Yanjie Zhang, Ming Xu
Publikováno v:
Molecular Oncology, Vol 18, Iss 9, Pp 2314-2330 (2024)
Androgen‐regulated DNA damage response (DDR) is one of the essential mechanisms in prostate cancer (PCa), a hormone‐sensitive disease. The heterogeneous nuclear ribonucleoprotein K (hnRNPK)‐homology splicing regulatory protein known as far upst
Externí odkaz:
https://doaj.org/article/9a39442787ce423ba7555c833b7e0f53
Autor:
Jianfeng He, Caihu Huang, Yanmin Guo, Rong Deng, Lian Li, Ran Chen, Yanli Wang, Jian Huang, Junke Zheng, Xian Zhao, Jianxiu Yu
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 580-605 (2024)
Homologous recombination (HR) repair for DNA double‐strand breaks (DSBs) is critical for maintaining genome stability and conferring the resistance of tumor cells to chemotherapy. Nuclear PTEN which contains both phosphatidylinositol 3,4,5‐trisph
Externí odkaz:
https://doaj.org/article/f277e1ff74bb4e799df39db79db3e387
Autor:
Runhui Lu, Yafan Zhang, Ran Chen, Lian Li, Caihu Huang, Zihan Zhou, Yingting Cao, Hongyan Li, Junya Li, Yixin Zhang, Yanli Wang, Jian Huang, Xian Zhao, Jing Feng, Jianxiu Yu, Chunling Du
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 59, Iss , Pp 101082- (2025)
The KRAS/ERK pathway is crucial in cancer progression and chemotherapy resistance, yet its upstream regulatory mechanism remains elusive. We identified MSI2 as a new promoter of chemotherapy resistance in cancers. MSI2 directly binds to a specific cl
Externí odkaz:
https://doaj.org/article/f327cd41a7134e4dafa9e8d3e381f497
Autor:
Xiaojia Liu, Runhui Lu, Qianqian Yang, Jianfeng He, Caihu Huang, Yingting Cao, Zihan Zhou, Jiayi Huang, Lian Li, Ran Chen, Yanli Wang, Jian Huang, Ruiyu Xie, Xian Zhao, Jianxiu Yu
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 170-189 (2024)
Endoribonuclease DICER is an RNase III enzyme that mainly processes microRNAs in the cytoplasm but also participates in nuclear functions such as chromatin remodelling, epigenetic modification and DNA damage repair. The expression of nuclear DICER is
Externí odkaz:
https://doaj.org/article/08e7cbeac8cb4d8e967a197af94d9b90
Autor:
Xian Zhao, Yingting Cao, Runhui Lu, Zihan Zhou, Caihu Huang, Lian Li, Jiayi Huang, Ran Chen, Yanli Wang, Jian Huang, Jinke Cheng, Junke Zheng, Yujie Fu, Jianxiu Yu
Publikováno v:
Advanced Science, Vol 11, Iss 15, Pp n/a-n/a (2024)
Abstract Non‐small‐cell lung cancer (NSCLC) is a highly lethal tumor that often develops resistance to targeted therapy. It is shown that Tank‐binding kinase 1 (TBK1) phosphorylates AGO2 at S417 (pS417‐AGO2), which promotes NSCLC progression
Externí odkaz:
https://doaj.org/article/b52bb434766f4888b2363bcc83ae8ad5
Autor:
Jianfang Li, Xinwei Wu, Jie Ke, Minjung Lee, Qingping Lan, Jia Li, Jianxiu Yu, Yun Huang, De-Qiang Sun, Ruiyu Xie
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here the authors show that TET1 is required for the generation of functional insulin-producing cells, FOXA2 physically interacts with TET1 and contributes to specific recruitment of TET1 to mediate chromatin opening at the regulatory elements of panc
Externí odkaz:
https://doaj.org/article/e8616fcbbaf64fc5b549a8ba060813c6
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Post-translational modifications of proteins play very important roles in regulating RNA metabolism and affect many biological pathways. Here we mainly summarize the crucial functions of small ubiquitin-like modifier (SUMO) modification in RNA metabo
Externí odkaz:
https://doaj.org/article/1c6b28f5021e45b38d8fd7aec4254bdf
Autor:
Hailong Zhang, Xian Zhao, Yanmin Guo, Ran Chen, Jianfeng He, Lian Li, Zhe Qiang, Qianqian Yang, Xiaojia Liu, Caihu Huang, Runhui Lu, Jiayu Fang, Yingting Cao, Jiayi Huang, Yanli Wang, Jian Huang, Guo-Qiang Chen, Jinke Cheng, Jianxiu Yu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Met1-linked linear ubiquitination (M1-Ubi) is catalyzed by linear ubiquitin chain assembly complex (LUBAC). Here the authors show that Ago2 protein is M1-Ubi modified by LUBAC complex under hypoxia condition leading to less association of miRNA targe
Externí odkaz:
https://doaj.org/article/8322c7884bf545219a1b04b3f0a7aff7
Autor:
Rong Deng, Yanmin Guo, Lian Li, Jianfeng He, Zhe Qiang, Hailong Zhang, Ran Chen, Yanli Wang, Xian Zhao, Jianxiu Yu
Publikováno v:
Molecular Oncology, Vol 15, Iss 1, Pp 279-298 (2021)
Deubiquitinase BAP1 is an important tumor suppressor in several malignancies, but its functions and critical substrates in prostate cancer (PCa) remain unclear. Here, we report that the mRNA and protein expression levels of BAP1 are downregulated in
Externí odkaz:
https://doaj.org/article/0dcb49657b82423fb909bbd485d0bc96
Autor:
Jinzhuo Dou, Hailong Zhang, Ran Chen, Zimei Shu, Haihua Yuan, Xian Zhao, Yanli Wang, Jian Huang, Aiwu Zhou, Jianxiu Yu
Publikováno v:
Molecular Oncology, Vol 14, Iss 9, Pp 2288-2312 (2020)
LIN28A is a conserved RNA‐binding protein that inhibits the biogenesis of let‐7 microRNAs, thus promoting cancer progression. However, mechanisms underlying the activation of the LIN28A‐let‐7 signaling pathway remain poorly understood. Here,
Externí odkaz:
https://doaj.org/article/b13d1c5221cb47b3b0e837bac8a0e020