Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jianxin, Duan"'
Publikováno v:
Cailiao Baohu, Vol 55, Iss 12, Pp 156-165 (2022)
Epoxy resin coatings have been widely researched and applied in the field of corrosion prevention due to their excellent characteristics such as strong adhesion to the substrate， easy application and good corrosion resistance. The modification of e
Externí odkaz:
https://doaj.org/article/cd1e595f6d0a4fdb85d7f3cc1a774821
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundPrimary liver cancer (PLC) is a common and highly lethal malignancy in the world. Approximately 85% of PLC is hepatocellular carcinoma (HCC), and this study mainly focuses on HCC. The onset of liver cancer is insidious and often complicated
Externí odkaz:
https://doaj.org/article/f03ed761c71f4012808fa22ccdf0beb8
Publikováno v:
地震科学进展, Vol 50, Iss 6, Pp 8-13 (2020)
The Longjiang bridge with a main span of 1 196 m is the first suspension bridge in high seismic intensity region in China. Frequent earthquake activities pose a serious threat to the safety of bridge structures. During the construction of the bridge
Externí odkaz:
https://doaj.org/article/d3a7b4c8f3444c14b4a5da904fdabd79
Autor:
Richard B. Lock, Malcolm A. Smith, Beverly A. Teicher, Tillman Pearce, Chi-Sheng Shia, Charles G. Mullighan, Kathryn G. Roberts, Komal S. Rathi, Donald Jung, Fanying Meng, Yuelong Guo, Stephen W. Erickson, Chelsea Mayoh, Narimanne El-Zein, Cara E. Toscan, Zhaohui Gu, Lisa McDermott, Connor D. Jones, Tara Pritchard, JianXin Duan, Kathryn Evans
Purpose:OBI-3424 is a highly selective prodrug that is converted by aldo-keto reductase family 1 member C3 (AKR1C3) to a potent DNA-alkylating agent. OBI-3424 has entered clinical testing for hepatocellular carcinoma and castrate-resistant prostate c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1054e7a9f8ca25f82d9d09add67f38
https://doi.org/10.1158/1078-0432.c.6527832.v1
https://doi.org/10.1158/1078-0432.c.6527832.v1
Publikováno v:
Biophys J
Accurately predicting the protein thermostability changes upon single point mutations in silico is a challenge that has implications for understanding diseases as well as industrial applications of protein engineering. Free energy perturbation (FEP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f5fb7829ff1ac20e36374c80216df7
https://doi.org/10.1016/j.bpj.2020.05.020
https://doi.org/10.1016/j.bpj.2020.05.020
Publikováno v:
Frontiers in oncology. 12
Primary liver cancer (PLC) is a common and highly lethal malignancy in the world. Approximately 85% of PLC is hepatocellular carcinoma (HCC), and this study mainly focuses on HCC. The onset of liver cancer is insidious and often complicated with basi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f457ac489abda80efbe52cbc7552ab1a
https://pubmed.ncbi.nlm.nih.gov/35936728
https://pubmed.ncbi.nlm.nih.gov/35936728
Autor:
Linjie Yuan, Xianqiang Ma, Yunyun Yang, Xin Li, Weiwei Ma, Haoyu Yang, Jian-Wen Huang, Jing Xue, Simin Yi, Mengting Zhang, Ningning Cai, Qingyang Ding, Liping Li, Jianxin Duan, Satish Malwal, Chun-Chi Chen, Eric Oldfield, Rey-Ting Guo, Yonghui Zhang
Tumor cells and pathogen-infected cells are presented to human γδ T cells based on “inside-out” signaling in which metabolites called phosphoantigens (pAgs) inside target cells are recognized by the intracellular domain of a butyrophilin protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b84745a73b4f8924b6345fa3f3459836
https://doi.org/10.1101/2022.01.02.474068
https://doi.org/10.1101/2022.01.02.474068
Autor:
Fanying, Meng, Wan-Fen, Li, Donald, Jung, Chun-Chung, Wang, Tianyang, Qi, Chi-Sheng, Shia, Ren-Yu, Hsu, Yin-Cheng, Hsieh, Jianxin, Duan
Publikováno v:
Am J Cancer Res
AST-3424/OBI-3424 (denoted by 3424) is a novel prodrug bis-alkylating agent activated by AKR1C3. AKR1C3 is overexpressed in many types of cancer, particularly in liver, non-small cell lung, gastric, renal and CRPC cancer. Currently 3424 is being stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4787dab5eaeeb98185b253f8d02809f
https://pubmed.ncbi.nlm.nih.gov/34354865
https://pubmed.ncbi.nlm.nih.gov/34354865
Autor:
Upasana Mandal, Jianxin Duan, Thembaninskosi Gaule, Darren C. Tomlinson, Eric Feyfant, David J. Hughes, Michael J. McPherson, Gareth J. Howell, Christian Tiede, Thomas A. Edwards, Katarzyna Z. Zajac, Anna A Tang, Chi H. Trinh, Natalie Penswick, Adrian Whitehouse
Publikováno v:
Science Signaling. 10
This work was funded in part by a Leeds Cancer Research UK (CRUK) Development Fund and The Wellcome Trust (ISSF) (DJH), The Wellcome Trust (089330), BBSRC (BB/K000306/1 and BB/M006557/1) (AW) and The University of Leeds through Biomedical Health Rese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18bafec7b57c6bc3ade4f9a5a6ad091a
https://doi.org/10.1126/scisignal.aaj2005
https://doi.org/10.1126/scisignal.aaj2005
Publikováno v:
Journal of Computer-Aided Molecular Design. 29:165-182
3-D ligand conformations are required for most ligand-based drug design methods, such as pharmacophore modeling, shape-based screening, and 3-D QSAR model building. Many studies of conformational search methods have focused on the reproduction of cry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae04b9dcbb2a460dbb99a3b8b38c2370
https://doi.org/10.1007/s10822-014-9813-4
https://doi.org/10.1007/s10822-014-9813-4