NIPBL-mediated RAD21 facilitates tumorigenicity by the PI3K pathway in non-small-cell lung cancer

Autor: Xiaoling Xu, Ding Wang, Weizhen Xu, Huihui Li, Ning Chen, Na Li, Qifeng Yao, Wei Chen, Jianxiang Zhong, Weimin Mao

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)

Abstract It is urgent to identify novel early diagnostic markers and therapeutic targets for non-small-cell lung cancer (NSCLC), which accounts for 85% of lung cancer cases and has a 5-year survival rate of 4–17%. Here, chromatin immunoprecipitatio

Externí odkaz: https://doaj.org/article/7c265ba3a22546faa372452223606f0f

Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy

Autor: Penghua Yang, Cheng Xu, E. Albert Reece, Xi Chen, Jianxiang Zhong, Min Zhan, Deborah J. Stumpo, Perry J. Blackshear, Peixin Yang

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Neural tube defects can arise from high glucose levels caused by maternal diabetes, and MARCKS is required for neural tube closure. Here, Yang et al. show that acetylation and phosphorylation of MARCKS in hyperglycemic conditions causes mitochondrial

Externí odkaz: https://doaj.org/article/6f49908709a549058f956b7c2ba701a2

A nomogram model based on peripheral blood lymphocyte subsets to assess the prognosis of non-small cell lung cancer patients treated with immune checkpoint inhibitors

Autor: Xiaoling Xu, Ding Wang, Wei Chen, Na Li, Rafal Suwinski, Antonio Rossi, Rafael Rosell, Jianxiang Zhong, Yun Fan

Publikováno v: Translational Lung Cancer Research
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Transl Lung Cancer Res

Background: The primary aim of this study was to investigate the prognostic value of peripheral blood lymphocyte subsets in non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs). Methods: From 2018 to 2019, 82 p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b85eb9830831c9a991a89c14cb87c90
https://doi.org/10.21037/tlcr-21-899

Superoxide dismutase 2 overexpression alleviates maternal diabetes-induced neural tube defects, restores mitochondrial function and suppresses cellular stress in diabetic embryopathy

Autor: Rinat Gabbay-Benziv, Jianxiang Zhong, Cheng Xu, Peixin Yang, Xue Lin

Publikováno v: Free Radical Biology and Medicine. 96:234-244

Pregestational diabetes disrupts neurulation leading to neural tube defects (NTDs). Oxidative stress resulting from reactive oxygen species (ROS) plays a central role in the induction of NTD formation in diabetic pregnancies. We aimed to determine wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0aa9e361058839fe3c6231506bcf39
https://doi.org/10.1016/j.freeradbiomed.2016.04.030

Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy

Autor: Deborah J. Stumpo, Perry J. Blackshear, Cheng Xu, E. Albert Reece, Penghua Yang, Peixin Yang, Xi Chen, Min Zhan, Jianxiang Zhong

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Failure of neural tube closure results in severe birth defects and can be induced by high glucose levels resulting from maternal diabetes. MARCKS is required for neural tube closure, but the regulation and of its biological activity and function have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f88e7be6396c0164035a9f4e0e73e0
https://pubmed.ncbi.nlm.nih.gov/30655546