Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Jianwen Que"'
Autor:
Ziyuan Wang, Yinshan Fang, Ziyang Liu, Ning Hao, Hao Helen Zhang, Xiaoxiao Sun, Jianwen Que, Hongxu Ding
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract We leverage machine learning approaches to adapt nanopore sequencing basecallers for nucleotide modification detection. We first apply the incremental learning (IL) technique to improve the basecalling of modification-rich sequences, which a
Externí odkaz:
https://doaj.org/article/4813905bb4a6426c9e0c28fe5da3d321
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 5, Pp 2137-2152 (2024)
Estrogen is imperative to mammalian reproductivity, metabolism, and aging. However, the hormone activating estrogen receptor (ERs) α can cause major safety concerns due to the enrichment of ERα in female tissues and certain malignancies. In contras
Externí odkaz:
https://doaj.org/article/8dff7707dd294a02ae0eb024707902a9
Autor:
Yunyun Chen, Kun Zhang, Rui Zhang, Zhuo Wang, Liang Yang, Tingting Zhao, Shihui Zhang, Yong Lin, Hongzhou Zhao, Yongpan Liu, Yuxuan Wei, Yijian Zhou, Jiaying Zhang, Xianzong Ye, Jing Zhao, Xinxin Li, Jianwen Que, Songlin Shi, Kuancan Liu
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Emerging evidence indicates that SOX2 is an oncogene for esophageal squamous cell carcinoma (ESCC). However, direct targeting of SOX2 is not feasible given that this transcription factor plays important roles in the maintenance of tissues su
Externí odkaz:
https://doaj.org/article/ced1a9f5ddaa4e088e8ee701a6f2b632
Autor:
Akihiro Miura, Hemanta Sarmah, Junichi Tanaka, Youngmin Hwang, Anri Sawada, Yuko Shimamura, Takehiro Otoshi, Yuri Kondo, Yinshan Fang, Dai Shimizu, Zurab Ninish, Jake Le Suer, Nicole C Dubois, Jennifer Davis, Shinichi Toyooka, Jun Wu, Jianwen Que, Finn J Hawkins, Chyuan-Sheng Lin, Munemasa Mori
Publikováno v:
eLife, Vol 12 (2023)
Millions suffer from incurable lung diseases, and the donor lung shortage hampers organ transplants. Generating the whole organ in conjunction with the thymus is a significant milestone for organ transplantation because the thymus is the central orga
Externí odkaz:
https://doaj.org/article/5cf0469dedb0467cb9d40502533f7091
Autor:
Farah Ballout, Heng Lu, Lei Chen, Kannappan Sriramajayam, Jianwen Que, Zhipeng Meng, Timothy C. Wang, Silvia Giordano, Alexander Zaika, Oliver McDonald, Dunfa Peng, Wael El-Rifai
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Abstract Background Esophageal adenocarcinoma (EAC) is characterized by poor prognosis and low survival rate. Chronic gastroesophageal reflux disease (GERD) is the main risk factor for the development of Barrett’s esophagus (BE), a preneoplastic me
Externí odkaz:
https://doaj.org/article/edde4736e571425d8fff54e2221e9019
Autor:
Ravindran Caspa Gokulan, Kodisundaram Paulrasu, Jamal Azfar, Wael El-Rifai, Jianwen Que, Olivier G. Boutaud, Yuguang Ban, Zhen Gao, Monica Garcia Buitrago, Sergey I. Dikalov, Alexander I. Zaika
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 112024- (2023)
Summary: p53 is a key tumor suppressor that is frequently mutated in human tumors. In this study, we investigated how p53 is regulated in precancerous lesions prior to mutations in the p53 gene. Analyzing esophageal cells in conditions of genotoxic s
Externí odkaz:
https://doaj.org/article/7ea2dcfd51124855ae7d8e7d14fbf15f
Autor:
Huachao Huang, Yinshan Fang, Ming Jiang, Yihan Zhang, Jana Biermann, Johannes C Melms, Jennifer A Danielsson, Ying Yang, Li Qiang, Jia Liu, Yiwu Zhou, Manli Wang, Zhihong Hu, Timothy C Wang, Anjali Saqi, Jie Sun, Ichiro Matsumoto, Wellington V Cardoso, Charles W Emala, Jian Zhu, Benjamin Izar, Hongmei Mou, Jianwen Que
Publikováno v:
eLife, Vol 11 (2022)
Viral infection often causes severe damage to the lungs, leading to the appearance of ectopic basal cells (EBCs) and tuft cells in the lung parenchyma. Thus far, the roles of these ectopic epithelial cells in alveolar regeneration remain controversia
Externí odkaz:
https://doaj.org/article/a89690d63c0b4788974d3765d808f613
Autor:
Tai-Wei Li, Adam D. Kenney, Jun-Gyu Park, Guillaume N. Fiches, Helu Liu, Dawei Zhou, Ayan Biswas, Weiqiang Zhao, Jianwen Que, Netty Santoso, Luis Martinez-Sobrido, Jacob S. Yount, Jian Zhu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to NF-κB activation and induction of pro-inflammatory cytokines, though the underlying mechanism for this activation is not fully understood. Our results reveal that the SA
Externí odkaz:
https://doaj.org/article/92359d42839349c18b69b00619ad6b06
Autor:
Zhuo Wang, Junkai Wang, Hongzhou Zhao, Tingting Zhao, Yunyun Chen, Ming Jiang, Shihui Zhang, Yuxuan Wei, Jiaying Zhang, Yijian Zhou, Songlin Shi, Zhichao Fu, Yaxin Yang, Yujun Zhang, Ling Yang, Jianwen Que, Kuancan Liu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113309- (2022)
Elevated SOX2 protein levels are closely correlated with the increased incidence of esophageal squamous cell carcinoma (ESCC). However, establishing effective target measures for ESCC treatments continue to be researched. It has been previously propo
Externí odkaz:
https://doaj.org/article/35c29b9a71884adf930a993d8ca5cf56
Autor:
Manikandan Palrasu, Elena Zaika, Kodisundaram Paulrasu, Ravindran Caspa Gokulan, Giovanni Suarez, Jianwen Que, Wael El-Rifai, Richard M Peek, Monica Garcia-Buitrago, Alexander I Zaika
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010628 (2022)
Helicobacter pylori (H. pylori) is a common gastric pathogen that infects approximately half of the world's population. Infection with H. pylori can lead to diverse pathological conditions, including chronic gastritis, peptic ulcer disease, and cance
Externí odkaz:
https://doaj.org/article/254554bc69014a03868de78e3a912605