Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jianshuang Wang"'
Autor:
Ryan Johnson, Imran Rehmani, Mark Leahy, Abigail Walker, Xiaorong Liang, Brian Dean, Jianshuang Wang
Publikováno v:
Bioanalysis. 14:1377-1389
Volumetric absorption microsampling devices offer minimally invasive and user-friendly collection of capillary blood in volumes as low as 10 μl. Herein we describe the assay validation for determination of the selective estrogen receptor degrader gi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85496617a46ed186e9c4c922ce90f576
https://doi.org/10.4155/bio-2022-0189
https://doi.org/10.4155/bio-2022-0189
Publikováno v:
Biomedical Chromatography. 37
Microsampling technology for dried blood-derived samples provides an advantageous alternative to conventional venous blood for drug quantitation. Unlike conventional whole blood microsampling techniques, Noviplex is a novel, card-based technology for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02cad1106d94ad56a4866ee24eb00108
https://doi.org/10.1002/bmc.5554
https://doi.org/10.1002/bmc.5554
Autor:
Donglu Zhang, Binqing Wei, Jun Guo, Thomas H. Pillow, Buyun Chen, Chenghong Zhang, Leanna Staben, Dewakar Sangaraju, Gail Lewis Phillips, Dian Su, Yong Ma, Cyrus Khojasteh, Sudheer Bobba, Jianshuang Wang, Peter S. Dragovich, Shuai Wang
Publikováno v:
Drug Metabolism and Disposition. 47:547-555
Duocarmycins [including cyclopropyl pyrroloindole (CPI) or cyclopropyl benzoindole (CBI)] are a class of DNA minor-groove alkylators and seco-CPI/CBIs are synthetic pro-forms that can spirocyclize to CPI/CBI. Bis-CPI/CBIs are potential drug candidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e255053fc710a12d6fc9d091e76faf
https://doi.org/10.1124/dmd.118.085209
https://doi.org/10.1124/dmd.118.085209
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 164:62-69
Liquid chromatography tandem mass spectrometry (LC–MS/MS) has been a golden standard for high throughput small molecule bioanalysis in drug discovery for decades. Supercritical fluid chromatography (SFC) has caught more attention in recent decade d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90a978e68479b64396ad90162ab183e
https://doi.org/10.1016/j.jpba.2018.10.021
https://doi.org/10.1016/j.jpba.2018.10.021
Autor:
Dhruvitkumar S Sutaria, Vikram Malhi, Christopher Craggs, Eunpi Cho, Rucha Sane, Jianshuang Wang, Adam Harris, Patrick Twomey, Luna Musib
Publikováno v:
Journal of clinical pharmacology. 62(2)
Ipatasertib is a highly selective small-molecule pan-Akt inhibitor in clinical development. Ipatasertib is predominantly eliminated by the liver, and therefore the effect of hepatic impairment on ipatasertib pharmacokinetics (PK) was evaluated. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab88201fbfe34eff771acac8b77d9b5
https://pubmed.ncbi.nlm.nih.gov/34402068
https://pubmed.ncbi.nlm.nih.gov/34402068
Autor:
Dorothy Cheung, Jim Bush, Jeffrey M. Harris, Han Ting Ding, Yuan Chen, Christopher R. Cabanski, Alice Fong, Lin Pan, Jianshuang Wang
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 69:102051
BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease. Although anti-fibrotic treatments, such as pirfenidone, are available that reduce the rate of disease progression, these medications have limitations in tolerabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7859977008a09cc419f68fc2e45e45f3
https://doi.org/10.1016/j.pupt.2021.102051
https://doi.org/10.1016/j.pupt.2021.102051
Autor:
Moulay Hicham Alaoui Ismaili, Peter W. Fan, Cornelis E. C. A. Hop, Brian Dean, Yuan Chen, Jianshuang Wang, Matthew Wright, Susan Wong, Jialin Mao
Publikováno v:
Pharmaceutical Research. 34:2403-2414
The exposure of G2917 decreased by four-fold at oral doses of 100 mg/kg twice daily for seven days in cynomolgus monkeys. Additional investigative work was conducted to understand: (1) the causes for the significant reduction in G2917 exposure in mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8375221b8d61aa7b61dcb5d5e8aaf2a8
https://doi.org/10.1007/s11095-017-2246-8
https://doi.org/10.1007/s11095-017-2246-8
Autor:
Tracy Staton, Meire Bremer, Stephanie Cape, Yang Gao, Dennis Milanowski, Xiao Ding, Fang Cai, Jianshuang Wang, Brian Dean, Drew Dorshorst
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 133:96-104
In human respiratory disease studies, liquid samples such as nasal secretion (NS), lung epithelial lining fluid (ELF), or upper airway mucosal lining fluid (MLF) are frequently collected, but their volumes often remain unknown. The lack of volume inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b475ad4b909910335a40e5cf97bdec3
https://doi.org/10.1016/j.jpba.2016.11.001
https://doi.org/10.1016/j.jpba.2016.11.001
Publikováno v:
Analytical Chemistry. 88:8036-8042
Humans are exposed to N-nitroso compounds through environmental exposure and endogenous metabolism. Some N-nitroso compounds can be metabolically activated to yield diazoacetate, which is known to induce DNA carboxymethylation. DNA lesion measurement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f61a9d4b25e37cee34e272f4fe2e1a9
https://doi.org/10.1021/acs.analchem.6b01349
https://doi.org/10.1021/acs.analchem.6b01349
Publikováno v:
Nucleic Acids Research
N-nitroso compounds represent a common type of environmental and endogenous DNA-damaging agents. After metabolic activation, many N-nitroso compounds are converted into a diazoacetate intermediate that can react with nucleobases to give carboxymethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16fb843eed0db4796e8ec05bafe432d
http://europepmc.org/articles/PMC4333421
http://europepmc.org/articles/PMC4333421