Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jianshu Hu"'
Autor:
Jia Ke, Qi Lu, Xin Wang, Rui Sun, Zhe Jin, Xiaoyi Zhan, Jianshu Hu, David Chi-cheong Wan, Chun Hu
Publikováno v:
Molecules, Vol 23, Iss 8, p 1980 (2018)
The epidermal growth factor receptors (EGFRs), in which overexpression (known as upregulation) or overactivity have been associated with a number of cancers, has become an attractive molecular target for the treatment of selective cancers. We report
Externí odkaz:
https://doaj.org/article/73e3ae0432834b4084a44bd8dc244b17
Autor:
Jinwen Zhang, Mingfeng He, Qian Xie, Ailing Su, Kuangyang Yang, Lichu Liu, Jianhui Liang, Ziqi Li, Xiuxin Huang, Jianshu Hu, Qian Liu, Bing Song, Chun Hu, Lei Chen, Yan Wang
Publikováno v:
ACS Omega. 7:45023-45035
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fece5491717ce2df4edb0802a1fcced
https://doi.org/10.1021/acsomega.2c05376
https://doi.org/10.1021/acsomega.2c05376
Autor:
Jianshu Hu1, Elisa Venturi1, haralampos Sigalas1 charalampos.sigalas@pharm.ox.ac.uk, Takashi Murayama1, Miyuki Nishi1, Hiroshi Takeshima2, Rebecca Sitsapesan2
Publikováno v:
Journal of General Physiology. Nov2023, Vol. 155 Issue 11, p1-16. 19p.
Autor:
Maria Musgaard, Elisa Venturi, Rebecca Sitsapesan, Ming Lei, Charalampos Sigalas, Jianshu Hu, Carmen R. Valdivia, Abigail D. Wilson, Héctor H. Valdivia
Key points RyR2 mutations can cause type-1 catecholaminergic polymorphic ventricular tachycardia (CPVT1), a lethal, autosomal-dominant arrhythmic disease. However, the changes in RyR2 ion-channel function that result from the many different patient m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856e051f82ca4a632db88c66eec0d104
https://ora.ox.ac.uk/objects/uuid:7421fc54-4b61-4e5e-b05c-68743bb73ce3
https://ora.ox.ac.uk/objects/uuid:7421fc54-4b61-4e5e-b05c-68743bb73ce3
Autor:
Miyuki Nishi, Hiroshi Takeshima, Charalampos Sigalas, Elisa Venturi, Jianshu Hu, Takashi Murayama, Rebecca Sitsapesan
Publikováno v:
Journal of General Physiology. 154
Trimeric intracellular cation channels (TRIC-A and TRIC-B), found in the sarco/endoplasmic reticulum (SR/ER) and nuclear membranes, are thought to provide countercurrents to balance Ca2+-movements across the SR, but there is also evidence that they p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bd497a3e8f5375b09049f5032b2940e
https://doi.org/10.1085/jgp.2021ecc13
https://doi.org/10.1085/jgp.2021ecc13
Autor:
Qing-Guo Meng, David Chi Cheong Wan, Huang Erfang, Bing-Qi Zhang, Chun Hu, Jianshu Hu, Lan Zhang, Guang-Peng Meng, Chu-Ying Xiao, Jin Zhe
Publikováno v:
Chinese Chemical Letters. 30:2157-2159
Oxidative stress results in various pathologies and as consequence antioxidant agents have attracted uninterrupted attention. In this paper, a novel series of indole-3-carboxamide derivatives (6a–6l) were designed and synthesized based on the melat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0b219378bac7291688cfe386615caa8
https://doi.org/10.1016/j.cclet.2019.04.044
https://doi.org/10.1016/j.cclet.2019.04.044
Autor:
Abigail D, Wilson, Jianshu, Hu, Charalampos, Sigalas, Elisa, Venturi, Héctor H, Valdivia, Carmen R, Valdivia, Ming, Lei, Maria, Musgaard, Rebecca, Sitsapesan
Publikováno v:
J Physiol
Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is a lethal genetic disease causing arrhythmias and sudden cardiac death in children and young adults and is linked to mutations in the cardiac ryanodine receptor (RyR2). The effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::755b7b058f455089d138bc2e34587ff4
https://pubmed.ncbi.nlm.nih.gov/34676560
https://pubmed.ncbi.nlm.nih.gov/34676560
Publikováno v:
Redox Biology, Vol 34, Iss, Pp 101573-(2020)
Redox Biology
Redox Biology
Development of Keap1–Nrf2 interaction inhibitors is a promising strategy for the discovery of therapeutic agents against oxidative stress-mediated diseases. Two motifs of Nrf2, ETGE and DLG motif, are responsible for Keap1-Nrf2 binding. Previously,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ae15002026dea7ef891cf95bf10321
http://www.sciencedirect.com/science/article/pii/S2213231720305735
http://www.sciencedirect.com/science/article/pii/S2213231720305735
Autor:
Ping Wang, Yan Wang, Tsz Ming Ip, Yong-Tang Zheng, Huangquan Lin, Liu Meng Yang, Jianshu Hu, David Chi-Cheong Wan
Publikováno v:
Journal of Chemical Information and Modeling. 57:2336-2343
Protein-protein interaction between lens epithelium-derived growth factor (LEDGF/p75) and HIV-1 integrase becomes an attractive target for anti-HIV drug development. The blockade of this interaction by small molecules could potentially inhibit HIV-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0168c1eb69e9309ec2b3d63b1f69d0
https://doi.org/10.1021/acs.jcim.7b00402
https://doi.org/10.1021/acs.jcim.7b00402
Publikováno v:
Biophysical Journal. 120:150a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87454f9837d2655a4e23be69fae5ff68
https://doi.org/10.1016/j.bpj.2020.11.1096
https://doi.org/10.1016/j.bpj.2020.11.1096