Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Jiansheng Jiang"'
Publikováno v:
IUCrJ, Vol 11, Iss 3, Pp 287-298 (2024)
This work focuses on molecules that are encoded by the major histocompatibility complex (MHC) and that bind self-, foreign- or tumor-derived peptides and display these at the cell surface for recognition by receptors on T lymphocytes (T cell receptor
Externí odkaz:
https://doaj.org/article/ecc49383e4974d0ba938c62a7c7b70d2
Autor:
Jiansheng Jiang, Christopher T. Boughter, Javeed Ahmad, Kannan Natarajan, Lisa F. Boyd, Martin Meier-Schellersheim, David H. Margulies
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract The COVID-19 pandemic and SARS-CoV-2 variants have dramatically illustrated the need for a better understanding of antigen (epitope)-antibody (paratope) interactions. To gain insight into the immunogenic characteristics of epitopic sites (ES
Externí odkaz:
https://doaj.org/article/a054579999df4ca3962667ef9a71ae44
Autor:
Jiansheng Jiang, Daniel K. Taylor, Ellen J. Kim, Lisa F. Boyd, Javeed Ahmad, Michael G. Mage, Hau V. Truong, Claire H. Woodward, Nikolaos G. Sgourakis, Peter Cresswell, David H. Margulies, Kannan Natarajan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The catalytic chaperone tapasin assists peptide loading onto MHC-I molecules for antigen presentation and immune recognition. Here, the authors present crystal structures that provide insights into the molecular mechanism of tapasin-mediated peptide
Externí odkaz:
https://doaj.org/article/c0903e0c423a49729d8d0a758d83bc5c
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Peptide loading of MHC-I molecules plays a critical role in the T cell response to infections and tumors as well as to interactions with inhibitory receptors on natural killer (NK) cells. To facilitate and optimize peptide acquisition, vertebrates ha
Externí odkaz:
https://doaj.org/article/61680c52186a49d0a779f414c450671a
Autor:
David H. Margulies, Daniel K. Taylor, Jiansheng Jiang, Lisa F. Boyd, Javeed Ahmad, Michael G. Mage, Kannan Natarajan
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immune recognition by T lymphocytes and natural killer (NK) cells is in large part dependent on the identification of cell surface MHC molecules bearing peptides generated from either endogenous (MHC I) or exogenous (MHC II) dependent pathways. This
Externí odkaz:
https://doaj.org/article/4f2ff701293a4c0aac80f4c8856fbb79
Autor:
Kannan Natarajan, Andrew C. McShan, Jiansheng Jiang, Vlad K Kumirov, Rui Wang, Huaying Zhao, Peter Schuck, Mulualem E. Tilahun, Lisa F. Boyd, Jinfa Ying, Ad Bax, David H. Margulies, Nikolaos G. Sgourakis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Binding of T cell receptors (TCR) to peptide-loaded major histocompatibility complexes (p/MHC) leads to T-cell activation. Here the authors give structural insights into T-cell signalling and show that p/MHC binding induces conformational changes at
Externí odkaz:
https://doaj.org/article/ab8774b12af24665974fefb843895dad
Autor:
Kannan Natarajan, Jiansheng Jiang, Nathan A. May, Michael G. Mage, Lisa F. Boyd, Andrew C. McShan, Nikolaos G. Sgourakis, Ad Bax, David H. Margulies
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Antigen presentation is a cellular process that involves a number of steps, beginning with the production of peptides by proteolysis or aberrant synthesis and the delivery of peptides to cellular compartments where they are loaded on MHC class I (MHC
Externí odkaz:
https://doaj.org/article/b399f764e4124bf6b9d60d4c3f366d5f
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190547 (2018)
NLRP12 is a NOD-like receptor that plays multiple roles in both inflammation and tumorigenesis. Despite the importance, little is known about its mechanism of action at the molecular level. Here, we report the crystal structure of NLRP12 PYD domain a
Externí odkaz:
https://doaj.org/article/1145eec1ed8f4d8ba8614c7a48208e47
Publikováno v:
Frontiers in Immunology; 2023, p1-9, 9p
Autor:
Jiansheng Jiang, Tengchuan Jin, Xiaojiao Fan, Huan Ma, Feng Chen, Patrick F. Smith, Tsan Sam Xiao, Leonie Unterholzner, Dan Zhao
Publikováno v:
Nucleic Acids Research
The interferon gamma-inducible protein 16 (IFI16) and its murine homologous protein p204 function in non-sequence specific dsDNA sensing; however, the exact dsDNA recognition mechanisms of IFI16/p204, which harbour two HIN domains, remain unclear. In