Zobrazeno 1 - 10
of 474
pro vyhledávání: '"Jianru Xiao"'
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract LOXL2, an enzyme belonging to the LOX family, facilitates the cross-linking of extracellular matrix (ECM) elements. However, the roles of the LOXL2 gene in mechanisms of oncogenesis and tumor development have not been clearly defined. In thi
Externí odkaz:
https://doaj.org/article/d5003ba33aa1485795138cdb64810c4f
Autor:
Zhenxi Li, Xinghai Yang, Ruifeng Fu, Zhipeng Wu, Shengzhao Xu, Jian Jiao, Ming Qian, Long Zhang, Chunbiao Wu, Tianying Xie, Jiqiang Yao, Zhixiang Wu, Wenjun Li, Guoli Ma, Yu You, Yihua Chen, Han-kun Zhang, Yiyun Cheng, Xiaolong Tang, Pengfei Wu, Gewei Lian, Haifeng Wei, Jian Zhao, Jianrong Xu, Lianzhong Ai, Stefan Siwko, Yue Wang, Jin Ding, Gaojie Song, Jian Luo, Mingyao Liu, Jianru Xiao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Osteoclasts are over-activated as we age, which results in bone loss. Src deficiency in mice leads to severe osteopetrosis due to a functional defect in osteoclasts, indicating that Src function is essential in osteoclasts. G-protein-coupled
Externí odkaz:
https://doaj.org/article/0890b5c3600c4d14b91eb72f87712feb
Publikováno v:
Orthopaedic Surgery, Vol 16, Iss 1, Pp 78-85 (2024)
Objective Recurrent giant cell tumor (RGCT) of the spine represents a clinical challenge for surgeons, and the treatment strategy remains controversial. This study aims to describe the long‐term follow‐up outcomes and compare the efficacy of en b
Externí odkaz:
https://doaj.org/article/34145dcb05f64fb4878413f882474959
Autor:
Shuai Yang, Qingping Zou, Ying Liang, Dapeng Zhang, Lina Peng, Wei Li, Wenxuan Li, Mengxing Liu, Ying Tong, Lu Chen, Peng Xu, Zhicong Yang, Kaicheng Zhou, Jianru Xiao, Hailin Wang, Wenqiang Yu
Publikováno v:
MedComm, Vol 5, Iss 4, Pp n/a-n/a (2024)
Abstract High metastatic propensity of osteosarcoma leads to its therapeutic failure and poor prognosis. Although nuclear activation miRNAs (NamiRNAs) are reported to activate gene transcription via targeting enhancer and further promote tumor metast
Externí odkaz:
https://doaj.org/article/69d77d1a5cc54a2ab94bd70844946102
Autor:
Guilai Zuo, Pengzhen Zhuang, Xinghai Yang, Qi Jia, Zhengwei Cai, Jin Qi, Lianfu Deng, Zhenhua Zhou, Wenguo Cui, Jianru Xiao
Publikováno v:
Advanced Science, Vol 11, Iss 5, Pp n/a-n/a (2024)
Abstract Destruction of cartilage due to the abnormal remodeling of subchondral bone (SB) leads to osteoarthritis (OA), and restoring chondro‐bone metabolic homeostasis is the key to the treatment of OA. However, traditional intra‐articular injec
Externí odkaz:
https://doaj.org/article/ff17811203714f8cbddf45a3ca349d89
Autor:
Fucun Liu, Juelan Ye, Shouli Wang, Yang Li, Yuhang Yang, Jianru Xiao, Aimin Jiang, Xuhua Lu, Yunli Zhu
Publikováno v:
Mediators of Inflammation, Vol 2024 (2024)
Background. Rheumatoid arthritis (RA) remains one of the most prevalent chronic joint diseases. However, due to the heterogeneity among RA patients, there are still no robust diagnostic and therapeutic biomarkers for the diagnosis and treatment of RA
Externí odkaz:
https://doaj.org/article/5a199d6035f74b3dbcec1136c242e7f4
Autor:
Zijian Kang, Jing Wang, Tong Meng, Hao Zhang, Da Xu, Haiyi Gong, Zhenyan Chang, Zifu Li, Xingang Cui, Jianru Xiao, Adnan I. Qureshi, Wang Zhou, Jianmin Liu, Huji Xu
Publikováno v:
Journal of Bio-X Research, Vol 6, Iss 1, Pp 23-36 (2023)
Objective:. Although the neurological and olfactory symptoms of coronavirus disease 2019 have been identified, the neurotropic properties of the causative virus, severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2), remain unknown.
Externí odkaz:
https://doaj.org/article/bf47d7881009458fbe1052e723415647
Autor:
Hao Zhang, Ting Wang, Haiyi Gong, Runyi Jiang, Wang Zhou, Haitao Sun, Runzhi Huang, Yao Wang, Zhipeng Wu, Wei Xu, Zhenxi Li, Quan Huang, Xiaopan Cai, Zaijun Lin, Jinbo Hu, Qi Jia, Chen Ye, Haifeng Wei, Jianru Xiao
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-15 (2023)
Abstract Subclassification of tumors based on molecular features may facilitate therapeutic choice and increase the response rate of cancer patients. However, the highly complex cell origin involved in osteosarcoma (OS) limits the utility of traditio
Externí odkaz:
https://doaj.org/article/95b11ac4642a4c7fbd5ce9158816b1d9
Autor:
Shaohui He, Runyi Jiang, Haitao Sun, Jian Yang, Chen Ye, Weibo Liu, Xinghai Yang, Xiaopan Cai, Jianru Xiao
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background The surgical efficacy and prognostic outcomes of patients with unspecific malignant bone tumors (UMBTs) remain unclear. The study is to address: 1) What are the clinicopathological features and prognostic determinants for patients
Externí odkaz:
https://doaj.org/article/43dc55be48f84b06ae18bf58712c973a
Autor:
Tianying Xie, Sitong Chen, Jiang Hao, Pengfei Wu, Xuelian Gu, Haifeng Wei, Zhenxi Li, Jianru Xiao
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 4, Pp 445-462 (2022)
Bone metastasis is a frequent complication for cancers and an important reason for the mortality in cancer patients. After surviving in bone, cancer cells can cause severe pain, life-threatening hypercalcemia, pathologic fractures, spinal cord compre
Externí odkaz:
https://doaj.org/article/f6e9eb2cf44048419bea8bccb2a07a90