Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jianquan Zheng"'
Autor:
Kang Zhang, Zhe Zhao, Liting Lan, Xiaoli Wei, Liyun Wang, Xiaoyan Liu, Haitao Yan, Jianquan Zheng
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
The sigma-1 receptor is a 223 amino acids molecular chaperone with a single transmembrane domain. It is resident to eukaryotic mitochondrial-associated endoplasmic reticulum and plasma membranes. By chaperone-mediated interactions with ion channels,
Externí odkaz:
https://doaj.org/article/d8c621b88fea40348d59e130e4ce3ef3
Publikováno v:
ASN Neuro, Vol 5 (2013)
NMDARs ( N -methyl-d-aspartate receptors) mediate the predominantly excitatory neurotransmission in the CNS (central nervous system). Excessive release of glutamate and overactivation of NMDARs during brain ischemia and the hypoxia process are causal
Externí odkaz:
https://doaj.org/article/6cf8416a9a5a435088ddbfc6a0695ac3
Autor:
Nan Hua, Xiaoli Wei, Xiaoyan Liu, Xiaoyun Ma, Xinhua He, Rengong Zhuo, Zhe Zhao, Liyun Wang, Haitao Yan, Bohua Zhong, Jianquan Zheng
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e53170 (2012)
Lung cancers express the cholinergic autocrine loop, which facilitates the progression of cancer cells. The antagonists of mAChRs have been demonstrated to depress the growth of small cell lung cancers (SCLCs). In this study we intended to investigat
Externí odkaz:
https://doaj.org/article/1bbce5ce75244cc0a38a5b9caf23951e
Autor:
Yi Wu, Liyun Wang, Pingxiang Xu, Ming Xue, Xuelin Zhou, Junhai Xiao, Ying Liu, Jianquan Zheng
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
To compare and evaluate the differences of stereoselective activity, the binding affinity, metabolism, transport and molecular docking of phencynonate isomers to muscarinic acetylcholine receptor (mAChR) were investigated in this study. The rotation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354ff7d5bf55653f02f000a284b60956
https://pubmed.ncbi.nlm.nih.gov/30760797
https://pubmed.ncbi.nlm.nih.gov/30760797
Autor:
Zheng Yong, Jin Li, Jianquan Zheng, Shuzhuo Zhang, Xiao-Yan Liu, Weiwei Dai, Kang Zhang, Lujia Yang, Cheng Zhang
Publikováno v:
Brain Research. 1605:12-21
Small molecular inhibitors of Cav2.2 have been reported for the treatment of neuropathic pain; however, low selectivity and side effects limit their further development. In our study, a series of new compounds were designed and synthesized by optimiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891441f077fa0e1a16df21b585dd4570
https://doi.org/10.1016/j.brainres.2015.01.054
https://doi.org/10.1016/j.brainres.2015.01.054
Autor:
Shuzhuo Zhang, Jin Li, Hui Wang, Lujia Yang, Yuelei Jin, Xiao-Yan Liu, Zhi juan Ge, Jianquan Zheng
Publikováno v:
Brain Research. 1582:1-11
Methamphetamine (METH) is a psychostimulant drug. Abuse of METH produces long-term behavioral changes including behavioral, sensitization, tolerance, and dependence. It induces neurotoxic effects in several areas of the brain via enhancing dopamine (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f3c9b58a3f9d54a0fbcfec1e217141
https://doi.org/10.1016/j.brainres.2014.07.040
https://doi.org/10.1016/j.brainres.2014.07.040
The top ten biological processes related to gene changes between THP-treated and NS-treated aging rat index by GO biological process term. (DOC 40Â kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1a2fbdb2eb37fefb424498f1c3cb60
The top ten signal pathway processes that were differentially regulated according to gene expression changes between the THP-treated and NS-treated aging rat index by KEGG molecular pathway analyses. (DOC 40Â kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::462a1f54138d10c6f363662d879e95bd
Autor:
Lili Wang, Wei Chen, Jianquan Zheng, Long Long, Yunde Xie, Huo-Ling Tang, Zhibing Zheng, Zehui Gong, Song Li, Hongying Liu, Mu-Gen Chi
Publikováno v:
European Journal of Pharmacology. 637:178-185
MJ15, a novel cannabinoid CB(1) receptor selective antagonist was discovered. In receptor binding assays, MJ15 displayed a high affinity for rat cannabinoid CB(1) receptor (K(i)=27.2 pM, and IC(50)=118.9 pM), but a much lower affinity for rat cannabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9b62215a9898f8facb9a58f61d231f
https://doi.org/10.1016/j.ejphar.2010.03.040
https://doi.org/10.1016/j.ejphar.2010.03.040
Publikováno v:
2015 China Semiconductor Technology International Conference.
As technology scales into the deep submicron regime, on chip variation (OCV) has become a dominant factor which influences the performance and yield of the circuits. Considering OCV analysis in static timing analysis (STA) tools is therefore one of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::582140cb57cf4f21b62116ee0d9bde05
https://doi.org/10.1109/cstic.2015.7153482
https://doi.org/10.1109/cstic.2015.7153482