Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Jianqin Wan"'
Autor:
Lulu Ren, Jianqin Wan, Xiaoyan Li, Jie Yao, Yan Ma, Fanchao Meng, Shusen Zheng, Weidong Han, Hangxiang Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The immunosuppressive tumor microenvironment (TME) remains a major obstacle to tumor control and causes suboptimal responses to immune checkpoint blockade (ICB) therapy. Thus, developing feasible therapeutic strategies that trigger inflammat
Externí odkaz:
https://doaj.org/article/c80ba6f980094d91abb18d762bff89e5
Publikováno v:
Journal of Advanced Research, Vol 47, Iss , Pp 93-103 (2023)
Introduction: Organosilica nanoparticles (ONs), which are a new type of photoluminescent nanomaterial (PM) with excellent biocompatibility, have caught more attention in recent years. However, their applications are significantly impeded by the compl
Externí odkaz:
https://doaj.org/article/2eabf5e8f62a44308b10c2a6edef3e42
Autor:
Kangkang Ying, Yifeng Zhu, Jianqin Wan, Chenyue Zhan, Yuchen Wang, Binbin Xie, Peirong Xu, Hongming Pan, Hangxiang Wang
Publikováno v:
Bioactive Materials, Vol 20, Iss , Pp 449-462 (2023)
The recent remarkable success and safety of mRNA lipid nanoparticle technology for producing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has stimulated intensive efforts to expand nanoparticle strategies to treat various dis
Externí odkaz:
https://doaj.org/article/d19fd9f1554644068140a544ecc43b13
Autor:
Zhentao Yang, Haiyang Xie, Jianqin Wan, Yuchen Wang, Liang Zhang, Ke Zhou, Hong Tang, Wentao Zhao, Hangxiang Wang, Penghong Song, Shusen Zheng
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104594- (2023)
Summary: Background: Long-term treatment with immunosuppressants is necessary to attenuate allograft rejection following organ transplantation (OT). Consequently, the overall survival of OT recipients with malignancies has been substantially compromi
Externí odkaz:
https://doaj.org/article/12f4aa1a9e144b648e9502e2ce75d74c
Autor:
Xiaowei Shi, Liwei Shu, Minwen Wang, Jie Yao, Qigu Yao, Suchen Bian, Xiaona Chen, Jianqin Wan, Fu Zhang, Shusen Zheng, Hangxiang Wang
Publikováno v:
Advanced Science, Vol 10, Iss 15, Pp n/a-n/a (2023)
Abstract Immune checkpoint blockade (ICB) therapies have had a tremendous impact on cancer therapy. However, most patients harbor a poorly immunogenic tumor microenvironment (TME), presenting overwhelming de novo refractoriness to ICB inhibitors. To
Externí odkaz:
https://doaj.org/article/e7b49f998c8a46f4a01132d0265aae89
Supplementary Table S1. Hematology measurements for the mice after the treatment with saline, cabazitaxel and dCTX NPs. The blood samples were collected on day 0, 6, 11, and 15 post-administration. The data are presented as the means {plus minus} SD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1152fd5a8d28439a4788afc9b06c17c1
https://doi.org/10.1158/1535-7163.22518718
https://doi.org/10.1158/1535-7163.22518718
Taxane-based chemotherapeutics are clinically available as frontline treatment regimens for cervical cancer. However, drug resistance and life-threatening toxicity impair the clinical efficacy of taxanes, so more effective and less toxic therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3fa6e0579b04683f2bdc51ea5dce975
https://doi.org/10.1158/1535-7163.c.6542092.v1
https://doi.org/10.1158/1535-7163.c.6542092.v1
Supplementary Figure S2. The cytotoxicity of dCTX NPs compared with cabazitaxel against cancer cell lines in vitro. Analysis (A) and quantification (B) of apoptosis of HeLa and A549 cells after the treatment with dCTX NPs for 48 h. The drug concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1989c3221bd015c4bc9b349738258051
https://doi.org/10.1158/1535-7163.22518730
https://doi.org/10.1158/1535-7163.22518730
Supplementary methods for nanonparticle characterization, cell assays and histological analyses of tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e7aacfb8faf78e2425d615cd05d99a
https://doi.org/10.1158/1535-7163.22518721.v1
https://doi.org/10.1158/1535-7163.22518721.v1
Autor:
Shusen Zheng, Xiao Xu, Lin Zhou, Haiyang Xie, Penghong Song, Donghai Jiang, Zhen Li, Hui Li, Liqian Zhou, Jianqin Wan, Jiaping Wu, Tingting Guo, Lijiang Wang, Zhongjie Lu, Hangxiang Wang
Description of synthesis of compounds, additional experiments and procedures, and Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1274a4567b2509a895ef67e149974cf8
https://doi.org/10.1158/0008-5472.22416861
https://doi.org/10.1158/0008-5472.22416861