Výsledky vyhledávání - "Jianning Kang"

Akademický článek

Chondroitin Sulfate Proteoglycans Revisited: Its Mechanism of Generation and Action for Spinal Cord Injury.

Autor: Rui Yang, Ying Zhang, Jianning Kang, Ce Zhang, Bin Ning

Publikováno v: Aging & Disease; Feb2024, Vol. 15 Issue 1, p153-168, 16p

Functional archaic DNA regulates molecular variation and is associated with disease risk across global populations

Autor: Jianning Kang, Aimee S Ramgolam, Louise Le Vot, Robert S. Young

The human genome contains many remnants of its evolutionary history, including a large number of evolutionarily volatile loci which have been introduced since our divergence from primates. One particularly intriguing source of novel DNA sequences is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::feba9b0ac5c91e69cd1a55237879d474
https://doi.org/10.1101/2023.04.26.538367

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HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion

Autor: Julie Qiaojin Lin, Deepak Khuperkar, Sofia Pavlou, Stanislaw Makarchuk, Nikolaos Patikas, Flora C.Y. Lee, Jianning Kang, Sarah F. Field, Julia M. Zbiegly, Joshua L. Freeman, Jernej Ule, Emmanouil Metzakopian, Marc-David Ruepp, Giovanna R. Mallucci

SummaryEnhanced expression of the cold-shock protein RNA binding motif 3 (RBM3) is highly neuroprotective bothin vitroandin vivo. Whilst upstream signalling pathways leading to RBM3 expression have been described, the precise molecular mechanism of R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad63196bea6cb848a60d6e1de5dec639
https://doi.org/10.1101/2022.10.27.514062

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Apigenin inhibits fibrous scar formation after acute spinal cord injury through TGFβ/SMADs signaling pathway

Autor: Zhengxin Jin, Lige Tian, Ying Zhang, Xiaodi Zhang, Jianning Kang, Hui Dong, Nana Huang, Liuzhu Pan, Bin Ning

Publikováno v: CNS neurosciencetherapeutics. 28(11)

To investigate the effect of apigenin on fibrous scar formation after mouse spinal cord injury (SCI).The pneumatic impactor strike method was used to establish an SCI model. Mice were intraperitoneally injected with 5 mg/kg or 20 mg/kg apigenin daily

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b362e77c8ab71695020e5540877d8bbd
https://pubmed.ncbi.nlm.nih.gov/35906830

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Spatiotemporal dynamics of the cellular components involved in glial scar formation following spinal cord injury

Autor: Ce Zhang, Jianning Kang, Xiaodi Zhang, Ying Zhang, Nana Huang, Bin Ning

Publikováno v: Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 153

Spinal cord injury (SCI) triggers complex inflammatory and pathological processes that ultimately lead to scar formation, thus resulting in the severe and irreversible loss of function. The composition of spinal cord scars in SCI can be divided into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e0efca995fec88b8070e882b8cd265e
https://pubmed.ncbi.nlm.nih.gov/36076590

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miR-21a-5p Promotes Inflammation following Traumatic Spinal Cord Injury through Upregulation of Neurotoxic Reactive Astrocyte (A1) Polarization by Inhibiting the CNTF/STAT3/Nkrf Pathway

Autor: Bin Ning, Hui Dong, Jianning Kang, Jianan Chen, Xiaodi Zhang, Lige Tian, Zhengxin Jin, Ting-ting Meng, Xinyu Li, Guilian Yu, Yining Zhang, Ying Zhang

Publikováno v: International Journal of Biological Sciences

Reactive astrocytes are implicated in traumatic spinal cord injury (TSCI). Interestingly, naïve astrocytes can easily transform into neurotoxic reactive astrocytes (A1s) with inflammatory stimulation. Previous studies demonstrated that microRNA(miR)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9793c6c56ae3cd77f4303ddea2a18251
https://doi.org/10.7150/ijbs.60509

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CircPrkcsh, a circular RNA, contributes to the polarization of microglia towards the M1 phenotype induced by spinal cord injury and acts via the JNK/p38 MAPK pathway

Autor: Hong Lv, Jianan Chen, Ronghan Liu, Guilian Yu, Ying Zhang, Xinyu Li, Jianning Kang, Xiaodi Zhang, Bin Ning, Yining Zhang

Publikováno v: The FASEB Journal. 35

Spinal cord injury (SCI) is a complex pathological change that includes primary SCI and gradually evolves into secondary SCI. Accumulating evidence demonstrates that circular RNAs (circRNAs) are involved in the pathology of a variety of neurological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398a4be74402c46fc0320dc8a19c6dc4
https://doi.org/10.1096/fj.202100993r

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