Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jianming Shao"'
Autor:
Zhen Zuo, Xuesen Cheng, Salma Ferdous, Jianming Shao, Jin Li, Yourong Bao, Jean Li, Jiaxiong Lu, Antonio Jacobo Lopez, Juliette Wohlschlegel, Aric Prieve, Mervyn G. Thomas, Thomas A. Reh, Yumei Li, Ala Moshiri, Rui Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The development of the retina is under tight temporal and spatial control. To gain insights into the molecular basis of this process, we generate a single-nuclei dual-omic atlas of the human developing retina with approximately 220,000 nucle
Externí odkaz:
https://doaj.org/article/04607c5381984c0e9882f1c3957b1bb8
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-6 (2023)
Abstract Measurable residual disease (MRD) is an important biomarker in acute myeloid leukemia (AML). However, MRD cannot be detected in many patients using current methods. We developed a highly sensitive 5-hydroxymethylcytosine (5hmC) signature in
Externí odkaz:
https://doaj.org/article/76e4d4908f544017b1ea3174214deda5
Autor:
Jianming Shao, Yitian Xu, Randall J. Olsen, Saro Kasparian, Kai Sun, Sunil Mathur, Jun Zhang, Chuan He, Shu-Hsia Chen, Eric H. Bernicker, Zejuan Li
Publikováno v:
Cells, Vol 13, Iss 8, p 715 (2024)
Immune checkpoint inhibitors (ICIs) drastically improve therapeutic outcomes for lung cancer, but accurately predicting individual patient responses to ICIs remains a challenge. We performed the genome-wide profiling of 5-hydroxymethylcytosine (5hmC)
Externí odkaz:
https://doaj.org/article/420b9c0e33134000b039a23175fb6661
Publikováno v:
Cells, Vol 13, Iss 4, p 298 (2024)
Accurate prognostic markers are essential for guiding effective lung cancer treatment strategies. The level of 5-hydroxymethylcytosine (5hmC) in tissue is independently associated with overall survival (OS) in lung cancer patients. We explored the pr
Externí odkaz:
https://doaj.org/article/9aa30aca326b4372ae361f85158e4404
Autor:
Jianming Shao, Sihan Wang, Diana West-Szymanski, Jason Karpus, Shilpan Shah, Siddhartha Ganguly, Janice Smith, Youli Zu, Chuan He, Zejuan Li
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Aberrant changes in 5-hydroxymethylcytosine (5hmC) are a unique epigenetic feature in many cancers including acute myeloid leukemia (AML). However, genome-wide analysis of 5hmC in plasma cell-free DNA (cfDNA) remains unexploited in AML patie
Externí odkaz:
https://doaj.org/article/fecbd0adb67745feb66c56e8f089f7be
Publikováno v:
Clinical and Translational Discovery, Vol 2, Iss 4, Pp n/a-n/a (2022)
Abstract Background Early cancer detection can dramatically improve clinical outcomes and greatly reduce economic burden of patients. Plasma cell–free DNA (cfDNA) 5‐hydroxymethylcytosine (5hmC) is an emerging epigenetic marker for cancer diagnosi
Externí odkaz:
https://doaj.org/article/a220871cab1e4e918abf127855f13e64
Publikováno v:
Genes, Vol 14, Iss 6, p 1180 (2023)
Epigenetic abnormality is a hallmark of acute myeloid leukemia (AML), and aberrant 5-hydroxymethylcytosine (5hmC) levels are commonly observed in AML patients. As epigenetic subgroups of AML correlate with different clinical outcomes, we investigated
Externí odkaz:
https://doaj.org/article/cb9f57d760ac49939d35a4f09c30ed8b
Publikováno v:
Highlights in Science, Engineering and Technology. 15:22-27
In recent years, the industrial automation of cigarette enterprises has made great progress, and the underlying data acquisition, centralized control and condition monitoring systems have been established. The management has also established a large
Publikováno v:
Macromolecules. 55:7683-7694
Autor:
Jianming Shao, Lei Gao, Marco L. Leung, Bailey Gallinger, Cara Inglese, M. Stephen Meyn, Daniela Del Gaudio, Soma Das, Zejuan Li
Publikováno v:
Hematological Oncology. 40:475-478
To investigate germline predisposition in lymphoma, we performed whole-exome sequencing and discovered a novel variant (c.817-1GT) in programmed cell death 1 ligand 2 (PD-L2) in a family with early-onset lymphomas and other cancers. The variant was p