Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Jianlong, Lou"'
Autor:
Yongfeng Fan, Jianlong Lou, Christina C. Tam, Weihua Wen, Fraser Conrad, Priscila Leal da Silva Alves, Luisa W. Cheng, Consuelo Garcia-Rodriguez, Shauna Farr-Jones, James D. Marks
Publikováno v:
Toxins, Vol 15, Iss 5, p 316 (2023)
Equine-derived antitoxin (BAT®) is the only treatment for botulism from botulinum neurotoxin serotype G (BoNT/G). BAT® is a foreign protein with potentially severe adverse effects and is not renewable. To develop a safe, more potent, and renewable
Externí odkaz:
https://doaj.org/article/276c0b76216c46e0a1b5bb0297a8d1eb
Autor:
Yongfeng Fan, Zhengda Sun, Fraser Conrad, Weihua Wen, Lequn Zhao, Jianlong Lou, Yu Zhou, Shauna Farr-Jones, James D Marks
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0273512 (2022)
Generating specific monoclonal antibodies (mAbs) that neutralize multiple antigen variants is challenging. Here, we present a strategy to generate mAbs that bind seven subtypes of botulinum neurotoxin serotype F (BoNT/F) that differ from each other i
Externí odkaz:
https://doaj.org/article/7144f5bc7dae452e9022a675df09d5ef
Autor:
Consuelo Garcia-Rodriguez, Shude Yan, Isin N. Geren, Kristeene A. Knopp, Jianbo Dong, Zhengda Sun, Jianlong Lou, Fraser Conrad, Wei-Hua Wen, Shauna Farr-Jones, Theresa J. Smith, Jennifer L. Brown, Janet C. Skerry, Leonard A. Smith, James D. Marks
Publikováno v:
Toxins, Vol 13, Iss 9, p 641 (2021)
Human botulism can be caused by botulinum neurotoxin (BoNT) serotypes A to G. Here, we present an antibody-based antitoxin composed of four human monoclonal antibodies (mAbs) against BoNT/C, BoNT/D, and their mosaic toxins. This work built on our suc
Externí odkaz:
https://doaj.org/article/a25047536f784a189fd6ca0fc69595fc
Autor:
James D. Marks, Ulrik B. Nielsen, Birgit Schoeberl, Gregory P. Adams, Fraser Conrad, Jianlong Lou, Hao Zou, Brian D. Harms, Anne-Laure Goenaga, Yu Zhou
PDF file, 450KB, Biphasic distribution of the increase in binding affinity for conversion from monovalent to bivalent forms for antibodies with different intrinsic affinities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dad4b36218fddcc93214aa8599e29c9
https://doi.org/10.1158/1535-7163.22498900.v1
https://doi.org/10.1158/1535-7163.22498900.v1
Autor:
James D. Marks, Ulrik B. Nielsen, Birgit Schoeberl, Gregory P. Adams, Fraser Conrad, Jianlong Lou, Hao Zou, Brian D. Harms, Anne-Laure Goenaga, Yu Zhou
PDF file, 95KB, Comparison of cell-binding curves for low and high affinity anti-EGFR IgG antibodies at the experimental incubation time and a hypothetical time.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d912714f35509e5cb38fad73680d2e5
https://doi.org/10.1158/1535-7163.22498897
https://doi.org/10.1158/1535-7163.22498897
Autor:
James D. Marks, Ulrik B. Nielsen, Birgit Schoeberl, Gregory P. Adams, Fraser Conrad, Jianlong Lou, Hao Zou, Brian D. Harms, Anne-Laure Goenaga, Yu Zhou
PDF file, 52KB, Comparison of measured apparent IgG affinities vs affinities calculated by using a mathematical model on cells of different EGFR density (A431, MDAMB468, and MDAMB231).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80173de6710a95bc7f5e6126c03912b9
https://doi.org/10.1158/1535-7163.22498879.v1
https://doi.org/10.1158/1535-7163.22498879.v1
Autor:
James D. Marks, Ulrik B. Nielsen, Birgit Schoeberl, Gregory P. Adams, Fraser Conrad, Jianlong Lou, Hao Zou, Brian D. Harms, Anne-Laure Goenaga, Yu Zhou
PDF file, 56KB, Kinetic parameters used in the computational model of antibody binding.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01eaae82ca847d4d1067a9547389809e
https://doi.org/10.1158/1535-7163.22498882
https://doi.org/10.1158/1535-7163.22498882
Autor:
James D. Marks, Ulrik B. Nielsen, Birgit Schoeberl, Gregory P. Adams, Fraser Conrad, Jianlong Lou, Hao Zou, Brian D. Harms, Anne-Laure Goenaga, Yu Zhou
PDF file, 62KB.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c14f673a9ec3ffd164c3530441ffc2
https://doi.org/10.1158/1535-7163.22498894.v1
https://doi.org/10.1158/1535-7163.22498894.v1
Autor:
Charles S. Craik, Byron C. Hann, James D. Marks, Christopher J. Farady, Paul J. Phojanakong, Jianlong Lou, Eric L. Schneider, Molly R. Darragh
Supplementary Figure 2 from Tumor Detection by Imaging Proteolytic Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d333cbf685b218f0922b1f6ef2b21c1
https://doi.org/10.1158/0008-5472.22386578.v1
https://doi.org/10.1158/0008-5472.22386578.v1
Autor:
Charles S. Craik, Byron C. Hann, James D. Marks, Christopher J. Farady, Paul J. Phojanakong, Jianlong Lou, Eric L. Schneider, Molly R. Darragh
Supplementary Figure 4 from Tumor Detection by Imaging Proteolytic Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48840cf50c26f0a84ae789161a92f4f8
https://doi.org/10.1158/0008-5472.22386572
https://doi.org/10.1158/0008-5472.22386572